Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 768473..769144 Replicon chromosome
Accession NZ_AP022581
Organism Mycobacterium lacus strain JCM 15657

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag G6N24_RS03650 Protein ID WP_085159448.1
Coordinates 768716..769144 (+) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag G6N24_RS03645 Protein ID WP_085159450.1
Coordinates 768473..768712 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6N24_RS03630 766525..766872 + 348 WP_085159456.1 transcription initiation protein -
G6N24_RS03635 766886..768106 + 1221 WP_085159454.1 sigma-70 family RNA polymerase sigma factor -
G6N24_RS03640 768211..768417 + 207 WP_139822343.1 hypothetical protein -
G6N24_RS03645 768473..768712 + 240 WP_085159450.1 antitoxin Antitoxin
G6N24_RS03650 768716..769144 + 429 WP_085159448.1 type II toxin-antitoxin system VapC family toxin Toxin
G6N24_RS03655 769232..770389 + 1158 WP_085159446.1 thiolase family protein -
G6N24_RS03660 770386..771174 + 789 WP_085159444.1 crotonase/enoyl-CoA hydratase family protein -
G6N24_RS03665 771429..772442 - 1014 WP_085159442.1 NAD(P)/FAD-dependent oxidoreductase -
G6N24_RS03670 772519..773028 - 510 WP_085159441.1 isoprenylcysteine carboxyl methyltransferase family protein -
G6N24_RS03675 773022..774119 - 1098 WP_085159439.1 type III polyketide synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-128)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 15861.18 Da        Isoelectric Point: 7.9480

>T36220 WP_085159448.1 NZ_AP022581:768716-769144 [Mycobacterium lacus]
VRALLDINVLLALLDRDHVDHKRARAWITEEIEQGWASCAITQNGFVRIISQARYPSPVPVSHAIDMLARATRTPYHEFW
PCTVSILDVNAVDRSRLHSSKQVTDAYLLALAVEYGGRFVTFDQSVVRSAVPGAGKQHLTIL

Download         Length: 429 bp

>T36220 NZ_AP022581:768716-769144 [Mycobacterium lacus]
GTGCGGGCACTGTTGGACATCAATGTGCTGCTAGCCCTGCTCGACCGCGACCACGTCGACCATAAGCGGGCACGGGCCTG
GATCACCGAAGAAATCGAGCAGGGCTGGGCCTCGTGCGCGATTACCCAGAACGGTTTCGTCCGGATCATTAGCCAGGCGC
GCTATCCCAGTCCCGTCCCAGTCAGCCACGCGATCGACATGCTCGCTCGTGCAACGCGGACGCCCTATCACGAGTTCTGG
CCTTGCACCGTAAGCATTCTCGACGTGAACGCCGTCGATCGTTCCCGTCTGCACAGTTCCAAGCAGGTCACCGATGCTTA
CCTACTTGCACTCGCGGTCGAGTACGGCGGCAGGTTTGTCACTTTCGACCAGTCCGTTGTGCGCAGCGCGGTTCCCGGTG
CGGGAAAACAGCACCTGACAATTCTCTAG

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8755.78 Da        Isoelectric Point: 4.5720

>AT36220 WP_085159450.1 NZ_AP022581:768473-768712 [Mycobacterium lacus]
MRTTLTIDDDVLLAVKERALRENRTAGAVLSDLARQALTNQYASPAREADAFYGFEPLPHRGEAISNALIDRLRDDEAV

Download         Length: 240 bp

>AT36220 NZ_AP022581:768473-768712 [Mycobacterium lacus]
ATGCGCACCACGCTCACCATTGACGACGACGTCCTGCTGGCCGTTAAGGAGCGCGCTCTGCGGGAGAACCGGACCGCGGG
AGCGGTGCTATCGGACCTTGCCCGCCAAGCATTGACCAACCAATACGCCTCGCCCGCACGCGAAGCCGACGCGTTCTATG
GCTTCGAGCCGCTTCCGCATCGTGGCGAAGCCATCTCAAATGCGCTGATCGATCGGCTTCGTGACGACGAGGCCGTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References