Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 716809..717374 Replicon chromosome
Accession NZ_AP022581
Organism Mycobacterium lacus strain JCM 15657

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag G6N24_RS03410 Protein ID WP_085156941.1
Coordinates 717003..717374 (+) Length 124 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag G6N24_RS03405 Protein ID WP_085156938.1
Coordinates 716809..717006 (+) Length 66 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6N24_RS03375 712616..713848 - 1233 WP_179963462.1 hypothetical protein -
G6N24_RS03380 714020..714367 - 348 WP_085156926.1 DNA-binding protein -
G6N24_RS03385 714371..714603 - 233 Protein_670 hypothetical protein -
G6N24_RS03390 714879..715952 + 1074 WP_085156932.1 redox-regulated ATPase YchF -
G6N24_RS03395 716005..716241 + 237 WP_197743107.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
G6N24_RS03400 716238..716657 + 420 WP_085156935.1 type II toxin-antitoxin system VapC family toxin -
G6N24_RS03405 716809..717006 + 198 WP_085156938.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
G6N24_RS03410 717003..717374 + 372 WP_085156941.1 type II toxin-antitoxin system VapC family toxin Toxin
G6N24_RS03420 718066..718566 + 501 WP_085156948.1 glycoside hydrolase -
G6N24_RS03425 718749..719072 + 324 WP_085156951.1 antibiotic biosynthesis monooxygenase -
G6N24_RS03430 719069..719764 - 696 WP_085156954.1 guanylate cyclase -
G6N24_RS03435 719797..720006 + 210 WP_085156957.1 hypothetical protein -
G6N24_RS03440 719958..720791 - 834 WP_085156987.1 adenylate/guanylate cyclase domain-containing protein -
G6N24_RS03445 720871..721047 + 177 Protein_681 glucose-6-phosphate dehydrogenase -
G6N24_RS03450 721061..722083 + 1023 WP_085156960.1 decarboxylating 6-phosphogluconate dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-112)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(2-42)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 13509.67 Da        Isoelectric Point: 6.2157

>T36219 WP_085156941.1 NZ_AP022581:717003-717374 [Mycobacterium lacus]
MILVDTSIWIDHLHTAEPALVDLLGRAEVGCHRFVIEELALGSIKRRIEVLELLGQLSAFPALTHDEVLKLVDGKRLWGH
GLSSVDAHLLGSVAVVSGAKLWTRDKRLVAVSRQLGVEFDADQ

Download         Length: 372 bp

>T36219 NZ_AP022581:717003-717374 [Mycobacterium lacus]
ATGATCCTGGTCGACACATCGATATGGATTGACCACCTTCATACAGCGGAACCCGCGTTGGTGGACTTACTTGGGCGAGC
CGAGGTCGGCTGCCATCGGTTCGTCATCGAGGAGTTGGCCCTGGGGTCGATCAAGCGACGGATCGAAGTCCTCGAACTCC
TCGGCCAACTCAGCGCCTTTCCCGCTCTGACTCATGATGAAGTATTGAAACTCGTTGACGGAAAGCGCCTTTGGGGTCAT
GGGCTGAGCTCCGTCGACGCACACCTCCTTGGTTCGGTCGCGGTGGTGTCAGGAGCCAAACTGTGGACTCGCGACAAGCG
GCTCGTTGCGGTCAGTCGGCAGCTAGGGGTCGAATTCGACGCCGACCAGTGA

Antitoxin


Download         Length: 66 a.a.        Molecular weight: 6868.83 Da        Isoelectric Point: 12.0228

>AT36219 WP_085156938.1 NZ_AP022581:716809-717006 [Mycobacterium lacus]
VRTTITLDDALVDRAAELTGIRERSALVRAGLETLIRVESARRLAALGGSDPAATAAPRRRGRSA

Download         Length: 198 bp

>AT36219 NZ_AP022581:716809-717006 [Mycobacterium lacus]
GTGAGAACAACAATCACACTTGACGACGCGCTAGTCGACCGAGCCGCCGAACTGACCGGGATTCGGGAGAGGTCCGCGCT
GGTGCGCGCAGGTCTCGAGACGTTGATCCGGGTCGAGAGCGCGCGCAGGCTCGCCGCGCTCGGAGGTTCGGATCCGGCTG
CGACGGCGGCACCGCGCCGGCGCGGTCGCAGCGCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References