Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 373614..374178 Replicon chromosome
Accession NZ_AP022581
Organism Mycobacterium lacus strain JCM 15657

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag G6N24_RS01835 Protein ID WP_085156185.1
Coordinates 373614..373961 (-) Length 116 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag G6N24_RS01840 Protein ID WP_085156182.1
Coordinates 373948..374178 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6N24_RS01805 370132..370947 + 816 WP_085156202.1 DUF3027 domain-containing protein -
G6N24_RS01810 370944..371399 - 456 WP_085156199.1 SRPBCC family protein -
G6N24_RS01815 371444..371719 - 276 WP_085156196.1 DUF2530 domain-containing protein -
G6N24_RS01820 371884..372315 + 432 WP_085156193.1 MarR family transcriptional regulator -
G6N24_RS01825 372312..373166 + 855 WP_085156190.1 RNA methyltransferase -
G6N24_RS01830 373163..373450 + 288 WP_085156188.1 DUF2537 domain-containing protein -
G6N24_RS01835 373614..373961 - 348 WP_085156185.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
G6N24_RS01840 373948..374178 - 231 WP_085156182.1 ribbon-helix-helix domain-containing protein Antitoxin
G6N24_RS01845 374311..375066 - 756 WP_085156179.1 DUF3071 domain-containing protein -
G6N24_RS01850 375173..376291 - 1119 WP_139822173.1 phosphoserine transaminase -
G6N24_RS01855 376542..377579 + 1038 WP_139822172.1 diiron oxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-112)

Antitoxin

Ribbon-helix-helix protein, CopG

(3-37)


Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 12382.19 Da        Isoelectric Point: 11.3028

>T36217 WP_085156185.1 NZ_AP022581:c373961-373614 [Mycobacterium lacus]
MLRGEIWQVDLDPARGGEANKRRPAVIVSNDRATAAATRLGRGVVTVVPVTSNTEKVYPFQVLLSGANSGLAVDSKAQAE
QVRSVATQRLLRRIGRVSPAELTDLDNALRLHLAL

Download         Length: 348 bp

>T36217 NZ_AP022581:c373961-373614 [Mycobacterium lacus]
ATGCTGCGCGGTGAGATCTGGCAGGTCGACCTGGATCCAGCTCGCGGCGGCGAGGCGAACAAGCGGCGGCCGGCAGTCAT
CGTCAGCAACGACCGGGCCACCGCGGCCGCGACACGCCTCGGCCGCGGTGTGGTCACGGTTGTTCCGGTCACCAGCAACA
CCGAGAAGGTCTATCCATTCCAGGTCTTGTTGTCGGGGGCCAACAGTGGCCTCGCCGTCGATTCGAAGGCACAGGCCGAG
CAGGTCAGATCCGTCGCAACACAGCGCCTGTTGCGCCGAATCGGCCGAGTCTCCCCTGCCGAGCTGACCGATCTCGACAA
TGCGCTCAGGCTTCATTTGGCGCTGTAG

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8260.10 Da        Isoelectric Point: 4.2108

>AT36217 WP_085156182.1 NZ_AP022581:c374178-373948 [Mycobacterium lacus]
MKLSVSLSDEDVAALDAYVKRAGLPSRSAGLQRAVQMLRYPDLEDDYAEAWAQWSADECSAAWESTVGDGVTHAAR

Download         Length: 231 bp

>AT36217 NZ_AP022581:c374178-373948 [Mycobacterium lacus]
ATGAAACTGAGCGTGAGCTTGTCTGACGAGGACGTCGCAGCATTGGACGCATACGTCAAGAGGGCGGGGCTGCCGTCGCG
GTCGGCAGGTTTGCAGCGTGCGGTCCAGATGCTGCGCTACCCCGACCTTGAGGACGACTATGCCGAGGCATGGGCACAGT
GGTCTGCCGACGAGTGTTCGGCTGCGTGGGAGAGCACCGTTGGAGATGGCGTGACCCATGCTGCGCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References