Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pezAT/zeta-ParD
Location 4424042..4425047 Replicon chromosome
Accession NZ_AP022579
Organism Mycolicibacterium boenickei strain JCM 15653

Toxin (Protein)


Gene name pezT Uniprot ID -
Locus tag G6N57_RS21030 Protein ID WP_077740740.1
Coordinates 4424042..4424620 (-) Length 193 a.a.

Antitoxin (Protein)


Gene name pezA Uniprot ID -
Locus tag G6N57_RS21035 Protein ID WP_077740739.1
Coordinates 4424658..4425047 (-) Length 130 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6N57_RS21000 4420133..4420549 - 417 WP_077740745.1 hypothetical protein -
G6N57_RS21005 4420643..4421158 + 516 WP_077740744.1 hypothetical protein -
G6N57_RS21010 4421264..4422058 + 795 WP_097926360.1 thioesterase family protein -
G6N57_RS21015 4422055..4422660 - 606 WP_077740742.1 class I SAM-dependent methyltransferase -
G6N57_RS21020 4422710..4423348 - 639 WP_174814501.1 FKBP-type peptidyl-prolyl cis-trans isomerase -
G6N57_RS21025 4423388..4424023 + 636 WP_077740741.1 histidine phosphatase family protein -
G6N57_RS21030 4424042..4424620 - 579 WP_077740740.1 zeta toxin family protein Toxin
G6N57_RS21035 4424658..4425047 - 390 WP_077740739.1 hypothetical protein Antitoxin
G6N57_RS21040 4425117..4426133 - 1017 WP_077740738.1 TIGR03617 family F420-dependent LLM class oxidoreductase -
G6N57_RS21045 4426284..4427639 + 1356 WP_077740737.1 LysM peptidoglycan-binding domain-containing protein -
G6N57_RS21050 4428039..4428449 + 411 WP_077740736.1 transglycosylase family protein -
G6N57_RS21055 4428449..4429003 + 555 Protein_4175 GNAT family N-acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(4-135)

Antitoxin

ParD-like antitoxin of type II bacterial toxin-antitoxin system

(6-106)


Sequences

Toxin        


Download         Length: 193 a.a.        Molecular weight: 20860.95 Da        Isoelectric Point: 7.0296

>T36216 WP_077740740.1 NZ_AP022579:c4424620-4424042 [Mycolicibacterium boenickei]
VKRLDLVVGCNGAGKSTFVELTLSPLLPGCPFVNADEIAKRRWPENPAPHSYEAALVAAETRAKLIELGESFIAETVFSH
PSKLELIDDACAAGYTVILHCILIPEDLAVQRVRHRVQAGGHDVPEAKIRERYQRLWGLVAIAAMHADSATFYDNSTVNG
PRIVAQLAGGFVVGSPTWPKWTPAVLSSRWPG

Download         Length: 579 bp

>T36216 NZ_AP022579:c4424620-4424042 [Mycolicibacterium boenickei]
GTGAAACGCCTCGACCTCGTCGTCGGCTGCAACGGCGCCGGCAAGTCCACCTTCGTCGAACTCACCCTGTCACCGCTGCT
CCCCGGCTGCCCGTTCGTGAACGCGGACGAGATCGCCAAGCGACGCTGGCCCGAGAACCCTGCCCCGCACTCCTACGAGG
CGGCCCTGGTCGCCGCCGAAACGCGGGCCAAACTCATCGAGCTCGGTGAGTCCTTCATCGCCGAGACGGTGTTCTCCCAT
CCCTCCAAGCTCGAGCTGATCGACGACGCATGCGCCGCCGGGTACACCGTGATCCTGCACTGCATTCTGATCCCCGAAGA
CCTGGCCGTGCAGCGAGTGCGTCACCGCGTGCAGGCCGGTGGACATGACGTCCCCGAAGCCAAGATCCGCGAACGCTACC
AACGACTTTGGGGTCTCGTCGCGATCGCCGCGATGCACGCGGACTCGGCGACGTTCTACGACAACAGCACTGTCAACGGC
CCGCGCATCGTCGCTCAACTGGCCGGCGGATTCGTCGTCGGATCACCCACGTGGCCGAAATGGACACCCGCGGTGCTGAG
TTCGCGCTGGCCCGGTTAG

Antitoxin


Download         Length: 130 a.a.        Molecular weight: 13778.24 Da        Isoelectric Point: 5.2233

>AT36216 WP_077740739.1 NZ_AP022579:c4425047-4424658 [Mycolicibacterium boenickei]
MTETADRVTRFAADLMDSAAAEGARQSRSAKQQLDHWARVGRAVSSQHSAARRKVESALAGSTPLRELTAEEGAVFDAEI
AASIEENLARADYGKILAGRGITTVALDENGEIVQYRPDGTTTVLAHPQ

Download         Length: 390 bp

>AT36216 NZ_AP022579:c4425047-4424658 [Mycolicibacterium boenickei]
ATGACCGAGACCGCAGACCGGGTGACCCGGTTCGCCGCTGATCTCATGGACAGTGCCGCCGCGGAAGGCGCACGTCAGAG
CCGGTCGGCCAAGCAGCAACTCGACCACTGGGCCCGCGTGGGACGGGCGGTGTCCAGCCAGCACAGCGCGGCACGCCGCA
AGGTGGAGTCCGCTCTGGCGGGCAGTACTCCCCTGCGGGAGTTGACCGCCGAGGAAGGTGCCGTGTTCGACGCCGAGATC
GCCGCTTCCATAGAAGAGAACCTGGCGCGTGCCGACTACGGCAAGATCCTGGCCGGACGCGGCATCACCACCGTGGCGCT
CGACGAGAACGGCGAGATCGTGCAGTACCGCCCCGACGGCACCACCACGGTACTGGCGCACCCGCAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References