Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/Polyketide_cyc2(toxin)
Location 4643464..4644130 Replicon chromosome
Accession NZ_AP022576
Organism Mycobacterium florentinum strain JCM 14740

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID -
Locus tag G6N55_RS22160 Protein ID WP_085221918.1
Coordinates 4643657..4644130 (+) Length 158 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID -
Locus tag G6N55_RS22155 Protein ID WP_085221917.1
Coordinates 4643464..4643652 (+) Length 63 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6N55_RS22140 4638732..4639268 - 537 WP_085221914.1 G/U mismatch-specific DNA glycosylase -
G6N55_RS22145 4639311..4640891 + 1581 WP_085221915.1 serine hydrolase -
G6N55_RS22150 4640888..4643281 + 2394 WP_085221916.1 cation-translocating P-type ATPase -
G6N55_RS22155 4643464..4643652 + 189 WP_085221917.1 antitoxin Antitoxin
G6N55_RS22160 4643657..4644130 + 474 WP_085221918.1 SRPBCC family protein Toxin
G6N55_RS22165 4644286..4645083 + 798 WP_085221919.1 VOC family protein -
G6N55_RS22170 4645160..4645594 + 435 WP_085221920.1 hypothetical protein -
G6N55_RS22175 4645599..4646084 - 486 WP_139826815.1 VOC family protein -
G6N55_RS22180 4646122..4647636 - 1515 WP_085221922.1 carotenoid oxygenase family protein -
G6N55_RS22185 4647638..4648864 - 1227 WP_085221923.1 acetyl-CoA acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Polyketide cyclase/dehydrase

(1-142)

Antitoxin

Antitoxin Rv0909/MT0933

(4-52)


Sequences

Toxin        


Download         Length: 158 a.a.        Molecular weight: 16901.57 Da        Isoelectric Point: 10.3756

>T36214 WP_085221918.1 NZ_AP022576:4643657-4644130 [Mycobacterium florentinum]
MAKLSGSIDVPLPPAQAWTHASDLSRFKDWLSIHRVWRSKLPDDLQKGTVIESIVEVKGMLNRIKWTIVHYKPPEAMTLN
GDGVGGVKVKLIAKVKPKDDGSVVSFDVRLGGPALFGPIGVIVAAALRSDINESLERFVTVFTGPDPGRNGHGGAGR

Download         Length: 474 bp

>T36214 NZ_AP022576:4643657-4644130 [Mycobacterium florentinum]
ATGGCGAAGCTTTCCGGATCCATCGACGTACCCCTGCCGCCGGCCCAGGCCTGGACGCATGCCTCCGATCTGTCCCGCTT
CAAGGACTGGCTGAGCATCCACCGGGTGTGGCGCAGCAAGCTGCCCGACGACCTGCAAAAGGGCACGGTCATCGAATCCA
TCGTCGAGGTCAAGGGCATGCTCAACCGGATCAAGTGGACGATCGTGCACTACAAGCCGCCGGAGGCCATGACGCTCAAC
GGCGATGGCGTCGGCGGCGTCAAGGTCAAGCTGATTGCGAAGGTCAAACCGAAGGATGACGGATCGGTCGTCAGCTTCGA
CGTGCGCCTCGGTGGTCCCGCGCTGTTCGGCCCGATCGGCGTGATCGTGGCCGCCGCACTGAGAAGCGACATCAACGAAT
CCCTGGAAAGATTCGTCACCGTGTTCACCGGTCCCGATCCCGGTCGCAACGGGCATGGTGGCGCCGGCCGCTGA

Antitoxin


Download         Length: 63 a.a.        Molecular weight: 6764.45 Da        Isoelectric Point: 4.5086

>AT36214 WP_085221917.1 NZ_AP022576:4643464-4643652 [Mycobacterium florentinum]
MGFLDKAKDLLAQNADKVETAIDKAGEFVDDKTQGKYSDTIHKVQEEAKKAIDAQGPGDQQN

Download         Length: 189 bp

>AT36214 NZ_AP022576:4643464-4643652 [Mycobacterium florentinum]
ATGGGATTCCTGGACAAGGCGAAGGACCTGTTGGCGCAGAACGCCGACAAGGTCGAGACCGCGATCGACAAGGCCGGCGA
GTTCGTCGACGACAAGACGCAGGGCAAGTACTCCGACACCATCCACAAGGTGCAGGAAGAGGCCAAGAAGGCGATCGACG
CCCAGGGCCCCGGCGACCAGCAGAACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References