Detailed information of TA system TA036213

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pezAT/zeta-ParD
• Location: 2611199..2612202
• Replicon: chromosome
• Accession: NZ_AP022576
• Organism: Mycobacterium florentinum strain JCM 14740

Toxin (Protein)

• Gene name: pezT
• Uniprot ID: -
• Locus tag: G6N55_RS12160
• Protein ID: WP_085224467.1
• Coordinates: 2611199..2611777 (-)
• Length: 193 a.a.

Antitoxin (Protein)

• Gene name: pezA
• Uniprot ID: -
• Locus tag: G6N55_RS12165
• Protein ID: WP_085224469.1
• Coordinates: 2611774..2612202 (-)
• Length: 143 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G6N55_RS12140	2606858..2607646	-	789	WP_085224624.1	DUF4436 domain-containing protein	-
G6N55_RS12145	2607732..2609597	-	1866	WP_085224622.1	glutamine--fructose-6-phosphate transaminase (isomerizing)	-
G6N55_RS12150	2609875..2610339	+	465	WP_085224463.1	DUF2510 domain-containing protein	-
G6N55_RS12155	2610349..2611188	+	840	WP_085224465.1	hypothetical protein	-
G6N55_RS12160	2611199..2611777	-	579	WP_085224467.1	zeta toxin family protein	Toxin
G6N55_RS12165	2611774..2612202	-	429	WP_085224469.1	hypothetical protein	Antitoxin
G6N55_RS12170	2612319..2613362	+	1044	WP_085224471.1	LLM class F420-dependent oxidoreductase	-
G6N55_RS12175	2613367..2614776	-	1410	WP_085224473.1	hypothetical protein	-
G6N55_RS12180	2614779..2615096	-	318	WP_085224475.1	hypothetical protein	-
G6N55_RS12185	2615144..2616481	-	1338	WP_085224476.1	phosphoglucosamine mutase	-
G6N55_RS12190	2616628..2617101	-	474	WP_139826994.1	30S ribosomal protein S9	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	-	2583886..2623458	39572

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Zeta toxin domain (5-154)

Antitoxin

• ParD-like antitoxin of type II bacterial toxin-antitoxin system (6-106)

Sequences

Toxin

Protein

• Length: 193 a.a.
• Molecular weight: 21237.30 Da
• Isoelectric Point: 9.8406

>T36213 WP_085224467.1 NZ_AP022576:c2611777-2611199 [Mycobacterium florentinum]
MNRLDLVVGPNGAGKSTFVEFTLAPLLPTSVFVNADEIARQRWPADAAAHSYEAARIAADTRARLIELRRSFIAETVFSH
PSKLELTDSAHAASYTIVLHVLLIPEKLAVERVKHRVATGGHAVPEDKIRQRYQRLWTLVATAIARCDSATVYDNSALKG
PRIVAQMSFGQLDGTPTWPAWTPRELTSRWPA

Nucleotide

• Length: 579 bp

>T36213 NZ_AP022576:c2611777-2611199 [Mycobacterium florentinum]
ATGAACCGTCTCGACCTTGTTGTCGGGCCCAACGGAGCCGGTAAATCAACCTTCGTCGAATTCACGCTCGCGCCGCTGTT
GCCGACGAGCGTCTTCGTCAACGCCGACGAAATCGCCAGACAGCGCTGGCCTGCCGACGCTGCCGCCCATTCCTACGAGG
CCGCGCGGATTGCGGCCGATACCAGGGCGAGGCTCATCGAACTGCGCCGATCGTTCATCGCCGAAACGGTGTTTTCTCAC
CCGTCCAAACTCGAGCTGACCGACAGCGCACACGCGGCGTCCTACACCATTGTGCTGCACGTGCTGCTCATACCCGAGAA
GCTGGCCGTGGAGCGGGTCAAGCATCGGGTTGCCACCGGCGGACATGCCGTACCCGAAGACAAGATTCGTCAACGCTACC
AACGTCTTTGGACACTGGTTGCCACCGCCATCGCACGCTGCGACTCCGCCACCGTCTACGACAACAGTGCGCTCAAGGGC
CCTCGCATCGTCGCCCAAATGAGTTTCGGCCAGCTGGACGGGACACCCACGTGGCCGGCGTGGACACCTCGCGAGTTGAC
GTCGCGCTGGCCCGCATAA

Antitoxin

Protein

• Length: 143 a.a.
• Molecular weight: 15240.05 Da
• Isoelectric Point: 10.0828

>AT36213 WP_085224469.1 NZ_AP022576:c2612202-2611774 [Mycobacterium florentinum]
MAESVDRVTRFAADLVDSAKAEGARQSRSAKQQLDHWARVGRAVSSQHSAARRRVEAALAGDLELGELSVEEGVVFNAEI
AAAIQENLNQANYGKLLAKRGVTTVALNEAGEIVEYRPDGSSTVLTANSRPIRRKKVNAGAR

Nucleotide

• Length: 429 bp

>AT36213 NZ_AP022576:c2612202-2611774 [Mycobacterium florentinum]
ATGGCTGAGAGCGTGGATCGAGTTACCCGGTTCGCCGCCGACCTCGTCGACAGTGCGAAGGCCGAGGGTGCGCGGCAGAG
CCGATCGGCCAAGCAGCAGCTGGATCACTGGGCGCGGGTCGGGCGCGCGGTGTCGAGCCAGCACTCCGCTGCACGTCGCC
GGGTGGAGGCGGCGCTGGCCGGGGATTTGGAACTGGGCGAGCTGAGTGTCGAGGAAGGTGTCGTCTTCAACGCCGAAATC
GCCGCGGCGATCCAGGAAAACCTCAACCAGGCCAACTACGGCAAGCTGCTGGCCAAGCGTGGCGTCACCACCGTTGCCCT
TAACGAGGCCGGCGAGATCGTCGAATACCGGCCCGATGGCAGTTCGACCGTGTTGACGGCGAACTCGCGACCCATACGGC
GCAAGAAGGTGAACGCCGGGGCCCGATGA