36211

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 3908727..3909358 Replicon chromosome
Accession NZ_AP022575
Organism Mycobacterium shinjukuense strain JCM 14233

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag G6N20_RS17630 Protein ID WP_083052334.1
Coordinates 3908945..3909358 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag G6N20_RS17625 Protein ID WP_083052337.1
Coordinates 3908727..3908954 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6N20_RS17595 3905061..3905378 + 318 WP_083052349.1 ESX-1 secretion-associated protein -
G6N20_RS17600 3905395..3905700 + 306 WP_083052346.1 DUF2694 family protein -
G6N20_RS20500 3905705..3905848 - 144 WP_169715475.1 hypothetical protein -
G6N20_RS17605 3905928..3907103 + 1176 WP_083052343.1 DUF5631 domain-containing protein -
G6N20_RS17615 3907211..3907955 + 745 Protein_3478 PE family protein -
G6N20_RS17620 3908261..3908590 + 330 WP_083052340.1 DUF2710 family protein -
G6N20_RS17625 3908727..3908954 + 228 WP_083052337.1 hypothetical protein Antitoxin
G6N20_RS17630 3908945..3909358 + 414 WP_083052334.1 PIN domain nuclease Toxin
G6N20_RS17635 3910182..3911324 + 1143 WP_197745484.1 group II intron reverse transcriptase/maturase -
G6N20_RS17640 3911435..3911683 + 249 WP_083048258.1 ribbon-helix-helix protein, CopG family -
G6N20_RS17645 3911680..3912096 + 417 WP_083048256.1 type II toxin-antitoxin system VapC family toxin -
G6N20_RS17650 3912289..3913062 - 774 WP_083048277.1 TIGR03084 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(8-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 15085.39 Da        Isoelectric Point: 7.0159

>T36211 WP_083052334.1 NZ_AP022575:3908945-3909358 [Mycobacterium shinjukuense]
VAVTTWLIDKSAYTRLAESPDAQAWIDRIQRGMVRISTVTRLEVGYSFRTAAQTRRESVSPPLALMPVEYLTPAAEDRAV
RVQLMLADRGQHRGPSIPDLLVAALAEVSGLTVLALDKDFEVIAQLTGQSVERLRLA

Download         Length: 414 bp

>T36211 NZ_AP022575:3908945-3909358 [Mycobacterium shinjukuense]
GTGGCGGTGACCACGTGGCTCATCGACAAGTCGGCCTATACCCGGTTGGCCGAATCACCCGATGCGCAGGCATGGATTGA
TCGAATCCAACGCGGCATGGTGCGAATCAGCACGGTCACCAGACTTGAGGTTGGGTATTCCTTCCGGACCGCTGCGCAGA
CACGTCGGGAGTCCGTATCACCGCCTTTGGCCCTAATGCCGGTGGAATACCTCACTCCGGCGGCGGAAGATCGCGCAGTC
CGGGTGCAGCTGATGCTCGCCGATCGTGGCCAGCATCGTGGGCCATCGATCCCCGACCTTCTCGTCGCGGCCCTCGCAGA
AGTTTCCGGCCTCACAGTCTTGGCCCTGGACAAGGACTTTGAAGTGATCGCGCAGCTGACGGGGCAGTCGGTCGAGCGGC
TTCGCCTGGCGTAA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8252.26 Da        Isoelectric Point: 7.0139

>AT36211 WP_083052337.1 NZ_AP022575:3908727-3908954 [Mycobacterium shinjukuense]
MPDVLIRGLSEAAVARIDADAAAHGLSRNEYLRRRFEAERSPSEASGRFTIEDLRRAAEAAADLNNPKVMAAAWR

Download         Length: 228 bp

>AT36211 NZ_AP022575:3908727-3908954 [Mycobacterium shinjukuense]
ATGCCAGATGTACTGATCAGGGGTTTGTCAGAGGCCGCGGTCGCCCGCATCGACGCCGACGCTGCAGCTCACGGCCTTTC
CCGCAACGAGTATCTGCGTCGCAGGTTCGAAGCCGAGCGATCGCCGTCTGAAGCCAGCGGCAGATTCACCATCGAAGACC
TGCGCCGCGCGGCCGAAGCCGCCGCCGATCTCAACAATCCGAAAGTGATGGCGGCCGCGTGGCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References