36210

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 3503580..3504290 Replicon chromosome
Accession NZ_AP022575
Organism Mycobacterium shinjukuense strain JCM 14233

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag G6N20_RS15825 Protein ID WP_083045722.1
Coordinates 3503862..3504290 (+) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag G6N20_RS15820 Protein ID WP_083045721.1
Coordinates 3503580..3503837 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6N20_RS15805 3500654..3501559 - 906 WP_083045719.1 class I SAM-dependent methyltransferase -
G6N20_RS15810 3501642..3503222 - 1581 WP_083045826.1 PPE family protein -
G6N20_RS15815 3503237..3503383 - 147 WP_158084735.1 hypothetical protein -
G6N20_RS15820 3503580..3503837 + 258 WP_083045721.1 ribbon-helix-helix protein, CopG family Antitoxin
G6N20_RS15825 3503862..3504290 + 429 WP_083045722.1 type II toxin-antitoxin system VapC family toxin Toxin
G6N20_RS15830 3504303..3505211 - 909 WP_083045723.1 DUF2236 domain-containing protein -
G6N20_RS15835 3505300..3506013 + 714 WP_083045724.1 TetR/AcrR family transcriptional regulator -
G6N20_RS15840 3506005..3506589 - 585 WP_083045725.1 VOC family protein -
G6N20_RS15845 3506673..3506848 + 176 Protein_3133 TetR family transcriptional regulator -
G6N20_RS15850 3506930..3508063 + 1134 WP_083045827.1 alpha/beta hydrolase -
G6N20_RS15855 3508352..3508657 - 306 WP_083045726.1 metal-sensitive transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-141)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-36)


Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 15786.08 Da        Isoelectric Point: 6.8281

>T36210 WP_083045722.1 NZ_AP022575:3503862-3504290 [Mycobacterium shinjukuense]
MFLLDVNVLLAAHRGDHPNHQTVRPWFDRLLAADDPFTVPNLVWASFLRLATNRRIFEIPSPRADAFAFIDAVTAQPHHL
PTNPGPRHLALLRKLCDEADASGDLIPDAVLAAIAVEHHCAVVSLDRDFARFTSVRHVHPAV

Download         Length: 429 bp

>T36210 NZ_AP022575:3503862-3504290 [Mycobacterium shinjukuense]
ATGTTTCTTCTCGACGTCAACGTGCTGCTCGCTGCACACCGCGGCGACCATCCGAATCACCAAACCGTCCGCCCGTGGTT
CGATCGACTGCTTGCGGCCGACGACCCCTTCACAGTGCCCAACCTGGTATGGGCGTCGTTCCTCCGGCTGGCGACAAATC
GACGCATCTTCGAGATTCCGTCACCGCGAGCGGATGCATTCGCATTCATCGACGCCGTCACCGCCCAGCCCCATCACCTT
CCGACCAACCCCGGTCCCCGACACCTCGCACTGCTGCGAAAGCTCTGCGACGAGGCCGATGCGTCTGGCGACCTCATACC
CGACGCGGTACTCGCGGCCATAGCAGTGGAGCATCACTGCGCCGTGGTGAGCCTGGACAGGGATTTCGCCCGGTTCACCT
CGGTGCGCCACGTTCACCCGGCAGTCTGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9085.24 Da        Isoelectric Point: 9.1239

>AT36210 WP_083045721.1 NZ_AP022575:3503580-3503837 [Mycobacterium shinjukuense]
VRTTVSISDELLAAAKRRARERGQSLGAVIEDALRREFAAAHVGGARPTVPVFDGGTGPRRGLDLTSNRALSEVLDEGLE
LNSRM

Download         Length: 258 bp

>AT36210 NZ_AP022575:3503580-3503837 [Mycobacterium shinjukuense]
GTGCGCACCACCGTGTCGATCTCCGATGAACTACTCGCTGCCGCCAAACGCCGGGCCCGCGAGCGTGGCCAGTCGCTAGG
TGCGGTGATCGAGGACGCCCTTCGCCGCGAGTTCGCCGCCGCCCATGTGGGCGGCGCCCGCCCGACCGTCCCGGTTTTCG
ACGGCGGCACCGGTCCGCGGCGAGGCCTCGACCTGACCTCGAATCGGGCGTTGTCCGAAGTGCTCGACGAGGGCCTGGAA
CTGAACTCGCGGATGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References