Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PemK(toxin)
Location 3092338..3092920 Replicon chromosome
Accession NZ_AP022575
Organism Mycobacterium shinjukuense strain JCM 14233

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag G6N20_RS13975 Protein ID WP_083050894.1
Coordinates 3092558..3092920 (+) Length 121 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag G6N20_RS13970 Protein ID WP_083050892.1
Coordinates 3092338..3092574 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6N20_RS13945 3087619..3088020 - 402 WP_083050885.1 PIN domain-containing protein -
G6N20_RS13950 3088017..3088244 - 228 WP_083050922.1 antitoxin -
G6N20_RS20675 3088308..3088775 - 468 WP_179961561.1 hypothetical protein -
G6N20_RS13960 3089768..3090715 - 948 WP_083050887.1 DUF732 domain-containing protein -
G6N20_RS13965 3090726..3091883 - 1158 WP_083050890.1 hypothetical protein -
G6N20_RS13970 3092338..3092574 + 237 WP_083050892.1 antitoxin Antitoxin
G6N20_RS13975 3092558..3092920 + 363 WP_083050894.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
G6N20_RS13980 3093125..3093460 - 336 WP_083050897.1 DUF86 domain-containing protein -
G6N20_RS13985 3093450..3093755 - 306 WP_083050899.1 nucleotidyltransferase family protein -
G6N20_RS13990 3093826..3093981 - 156 WP_158084787.1 hypothetical protein -
G6N20_RS13995 3094033..3094992 - 960 WP_083050901.1 radical SAM protein -
G6N20_RS14000 3095382..3095906 - 525 WP_083050903.1 hypothetical protein -
G6N20_RS14005 3095908..3096234 - 327 WP_083050906.1 helix-turn-helix domain-containing protein -
G6N20_RS14010 3096797..3097912 - 1116 WP_083050908.1 galactokinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 121 a.a.        Molecular weight: 12695.70 Da        Isoelectric Point: 7.3623

>T36208 WP_083050894.1 NZ_AP022575:3092558-3092920 [Mycobacterium shinjukuense]
MTASPEPRRGELWLVALGAARVGEPGKHRPAVIVSVDDLLTGIDEELVVVVPVSSSRSGTPLRPHISPTEGVESASVAVC
RGVRAVARTRLLERLGTLAPDTMRHIEHALALILGIREAG

Download         Length: 363 bp

>T36208 NZ_AP022575:3092558-3092920 [Mycobacterium shinjukuense]
ATGACGGCATCGCCTGAGCCGCGACGCGGCGAGCTGTGGCTGGTGGCCCTCGGCGCCGCACGCGTCGGTGAACCCGGCAA
GCATCGGCCCGCCGTCATCGTCTCCGTAGATGACCTACTCACCGGGATCGATGAAGAGCTGGTAGTCGTCGTGCCCGTGT
CGAGCTCACGGTCGGGCACGCCACTACGGCCACATATCTCACCCACCGAGGGAGTGGAATCCGCCAGCGTCGCCGTGTGC
CGTGGCGTCCGCGCCGTCGCGCGCACCCGACTGCTGGAACGATTGGGAACCCTGGCGCCCGACACAATGCGCCACATCGA
ACACGCCCTCGCGCTGATTCTGGGTATCCGCGAGGCTGGCTGA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8692.51 Da        Isoelectric Point: 4.6533

>AT36208 WP_083050892.1 NZ_AP022575:3092338-3092574 [Mycobacterium shinjukuense]
MSTRTATIRVPVQTRDRLATQARERGVSIAALLTELASRAEHEAIFRAERDATRTEATVDAVHDEERDWDQTADDGIA

Download         Length: 237 bp

>AT36208 NZ_AP022575:3092338-3092574 [Mycobacterium shinjukuense]
ATGTCTACGCGCACAGCGACGATCAGGGTTCCGGTCCAGACTCGAGACCGCCTCGCCACCCAGGCGCGTGAACGTGGGGT
ATCCATTGCCGCGCTGCTCACCGAACTGGCCTCCCGCGCCGAGCACGAGGCCATCTTCCGCGCCGAACGCGACGCCACCC
GTACCGAAGCGACCGTCGACGCCGTGCACGACGAGGAACGCGACTGGGACCAAACAGCAGATGACGGCATCGCCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References