Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 3087619..3088244 Replicon chromosome
Accession NZ_AP022575
Organism Mycobacterium shinjukuense strain JCM 14233

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag G6N20_RS13945 Protein ID WP_083050885.1
Coordinates 3087619..3088020 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag G6N20_RS13950 Protein ID WP_083050922.1
Coordinates 3088017..3088244 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6N20_RS13930 3083069..3084796 + 1728 WP_083050879.1 exodeoxyribonuclease V subunit alpha -
G6N20_RS13935 3084830..3085981 + 1152 WP_083050882.1 FIST C-terminal domain-containing protein -
G6N20_RS13940 3086348..3087379 - 1032 WP_197745481.1 hypothetical protein -
G6N20_RS13945 3087619..3088020 - 402 WP_083050885.1 PIN domain-containing protein Toxin
G6N20_RS13950 3088017..3088244 - 228 WP_083050922.1 antitoxin Antitoxin
G6N20_RS20675 3088308..3088775 - 468 WP_179961561.1 hypothetical protein -
G6N20_RS13960 3089768..3090715 - 948 WP_083050887.1 DUF732 domain-containing protein -
G6N20_RS13965 3090726..3091883 - 1158 WP_083050890.1 hypothetical protein -
G6N20_RS13970 3092338..3092574 + 237 WP_083050892.1 antitoxin -
G6N20_RS13975 3092558..3092920 + 363 WP_083050894.1 type II toxin-antitoxin system PemK/MazF family toxin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(2-131)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 13966.68 Da        Isoelectric Point: 5.0579

>T36207 WP_083050885.1 NZ_AP022575:c3088020-3087619 [Mycobacterium shinjukuense]
VTMLLDANALIALVVAEHVHHDAAAEWLSASEAAFATCPITQGSLVRFLVRSGQSAAAAREVVSAVESANRHEFWPDTVS
FADVEVGGVVGHRQVTDAYLAQLARSRDGQLATLDSGLAHLHSDVAVLIPTTA

Download         Length: 402 bp

>T36207 NZ_AP022575:c3088020-3087619 [Mycobacterium shinjukuense]
GTGACGATGCTGCTCGATGCCAACGCGCTCATCGCGTTGGTGGTCGCCGAGCATGTGCACCACGACGCCGCCGCGGAGTG
GCTGTCAGCATCCGAGGCGGCGTTTGCGACTTGCCCGATCACGCAGGGAAGCCTTGTCCGATTCCTGGTGCGGTCGGGGC
AATCCGCGGCGGCTGCGCGGGAGGTCGTCAGTGCCGTCGAGAGTGCCAACCGTCACGAGTTTTGGCCGGACACTGTCTCT
TTCGCCGATGTCGAGGTCGGTGGTGTGGTCGGTCACCGACAGGTAACGGATGCCTACCTTGCCCAGCTCGCCCGCAGCCG
CGACGGACAGTTGGCGACTCTCGACAGTGGGCTGGCGCACCTGCACAGTGACGTCGCGGTGCTCATCCCGACGACCGCTT
GA

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8082.04 Da        Isoelectric Point: 5.6209

>AT36207 WP_083050922.1 NZ_AP022575:c3088244-3088017 [Mycobacterium shinjukuense]
VRTTIDLPDDLHKQALAIARDTHRTFSQTVADLIRRGLAAGSTAAISRDPRTGLPLVSVGTVVTSEDVRSLEDEQ

Download         Length: 228 bp

>AT36207 NZ_AP022575:c3088244-3088017 [Mycobacterium shinjukuense]
GTGCGCACCACCATCGATCTGCCCGACGACCTTCACAAACAGGCGCTGGCGATCGCGCGGGATACCCATCGCACGTTCAG
CCAAACGGTTGCGGATCTGATTCGACGCGGCCTGGCAGCCGGCAGCACCGCCGCGATCTCTCGAGACCCCAGAACGGGAT
TGCCTTTGGTGAGCGTGGGGACCGTCGTGACCTCCGAGGACGTGCGCTCATTGGAGGATGAGCAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References