Detailed information of TA system TA036206

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN-PHD
• Location: 2883605..2884272
• Replicon: chromosome
• Accession: NZ_AP022575
• Organism: Mycobacterium shinjukuense strain JCM 14233

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: G6N20_RS12930
• Protein ID: WP_083052302.1
• Coordinates: 2883605..2883997 (-)
• Length: 131 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: G6N20_RS12935
• Protein ID: WP_083052305.1
• Coordinates: 2883997..2884272 (-)
• Length: 92 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G6N20_RS12920	2881004..2882350	+	1347	WP_083052296.1	wax ester/triacylglycerol synthase family O-acyltransferase	-
G6N20_RS12925	2882393..2883535	+	1143	WP_083052299.1	trehalose-phosphatase	-
G6N20_RS12930	2883605..2883997	-	393	WP_083052302.1	type II toxin-antitoxin system VapC family toxin	Toxin
G6N20_RS12935	2883997..2884272	-	276	WP_083052305.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
G6N20_RS12940	2884453..2886550	+	2098	Protein_2557	PE family protein	-
G6N20_RS12945	2886699..2887571	-	873	WP_083045837.1	MaoC family dehydratase N-terminal domain-containing protein	-
G6N20_RS12950	2887645..2888358	+	714	WP_083045838.1	phosphoglycerate mutase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-120)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-66)

Sequences

Toxin

Protein

• Length: 131 a.a.
• Molecular weight: 14408.80 Da
• Isoelectric Point: 10.8322

>T36206 WP_083052302.1 NZ_AP022575:c2883997-2883605 [Mycobacterium shinjukuense]
MAAIYLDSSAIVKLAVREPESDALRRYLRTRHPRVSSAFARAEVMRALLDKGESARRAGRRALAHLDLLRVDKRVLDLAG
GLLPFELRTLDAIHLATAQRLGVDLGRLCTYDDRMRDAAKTLGMTVIAPS

Nucleotide

• Length: 393 bp

>T36206 NZ_AP022575:c2883997-2883605 [Mycobacterium shinjukuense]
ATGGCGGCCATCTATCTTGACTCGTCCGCCATCGTCAAGCTCGCGGTTCGTGAGCCGGAGTCGGACGCGCTGCGCCGCTA
CCTTCGCACCCGCCACCCGCGGGTGTCGAGTGCCTTTGCGCGCGCGGAGGTCATGCGGGCCCTGCTTGACAAGGGTGAAT
CAGCGCGGAGAGCCGGCCGCCGGGCGCTGGCTCATCTCGATCTGCTGCGCGTCGACAAGCGCGTCCTCGATCTCGCTGGT
GGGCTGCTGCCATTCGAGCTGCGCACGCTCGATGCCATCCACTTGGCGACGGCGCAGCGGCTCGGCGTCGATCTGGGCCG
GTTGTGCACCTACGACGACCGGATGCGCGACGCCGCCAAGACGCTCGGCATGACCGTGATCGCCCCGTCGTAA

Antitoxin

Protein

• Length: 92 a.a.
• Molecular weight: 9968.28 Da
• Isoelectric Point: 4.4400

>AT36206 WP_083052305.1 NZ_AP022575:c2884272-2883997 [Mycobacterium shinjukuense]
MTSVGVRELRQRASELLRRVEAGETIEITDRGRPVALLSPLPQGGPYEQLLASGEIERATLDAADLPEPLDLDAGVELPS
VTLARLREHER

Nucleotide

• Length: 276 bp

>AT36206 NZ_AP022575:c2884272-2883997 [Mycobacterium shinjukuense]
ATGACTTCGGTGGGTGTGCGTGAGCTGCGGCAGCGGGCCAGCGAGCTGCTGCGCCGTGTCGAGGCCGGCGAGACGATCGA
GATCACCGACCGCGGCCGGCCCGTCGCCCTGCTCTCGCCGCTGCCGCAGGGCGGTCCATATGAGCAGCTGCTGGCAAGCG
GCGAGATCGAGCGTGCCACGCTCGACGCCGCTGATCTGCCCGAACCGCTCGACCTCGACGCGGGCGTCGAGCTGCCGTCG
GTGACGCTTGCGCGCCTGCGTGAGCACGAGCGTTGA