36204

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2506911..2507555 Replicon chromosome
Accession NZ_AP022575
Organism Mycobacterium shinjukuense strain JCM 14233

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag G6N20_RS11280 Protein ID WP_083046149.1
Coordinates 2507139..2507555 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag G6N20_RS11275 Protein ID WP_083046150.1
Coordinates 2506911..2507132 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6N20_RS11260 2503561..2505033 - 1473 WP_142271846.1 wax ester/triacylglycerol synthase family O-acyltransferase -
G6N20_RS11265 2505219..2506472 - 1254 WP_083046151.1 alpha/beta hydrolase -
G6N20_RS11275 2506911..2507132 + 222 WP_083046150.1 antitoxin Antitoxin
G6N20_RS11280 2507139..2507555 + 417 WP_083046149.1 VapC toxin family PIN domain ribonuclease Toxin
G6N20_RS11285 2507583..2508773 - 1191 WP_083046148.1 2-oxo acid dehydrogenase subunit E2 -
G6N20_RS11290 2508770..2509804 - 1035 WP_083046147.1 3-methyl-2-oxobutanoate dehydrogenase subunit beta -
G6N20_RS11295 2509814..2510905 - 1092 WP_083046146.1 pyruvate dehydrogenase (acetyl-transferring) E1 component subunit alpha -
G6N20_RS11300 2511163..2511984 - 822 WP_083046145.1 CoA ester lyase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(2-133)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 14940.08 Da        Isoelectric Point: 6.8439

>T36204 WP_083046149.1 NZ_AP022575:2507139-2507555 [Mycobacterium shinjukuense]
VALLDVNALVALAWDSHIHHARIREWFAANAAQGWATCPVTESGFVRVSSNPKVLPNAIGIADARRVLTALRALEGHRFL
ADDVSLVDDDVPVIVGHRQVTDAHLLTLARRRGVRLVTFDTAVSALAQGHDVELLSTL

Download         Length: 417 bp

>T36204 NZ_AP022575:2507139-2507555 [Mycobacterium shinjukuense]
GTGGCGCTGCTCGACGTCAACGCGTTGGTCGCGCTGGCCTGGGACTCGCACATCCACCACGCGCGGATCCGTGAGTGGTT
CGCCGCCAACGCCGCGCAAGGCTGGGCGACCTGTCCGGTTACCGAAAGCGGCTTCGTGCGCGTGTCAAGCAACCCGAAAG
TGCTTCCCAACGCGATCGGGATCGCCGACGCCCGACGGGTGCTGACAGCGCTGCGCGCCCTGGAAGGTCACCGCTTCCTG
GCTGATGACGTATCGCTGGTCGATGACGACGTTCCGGTGATCGTCGGTCACCGCCAGGTGACCGACGCGCATCTGCTGAC
GCTGGCCCGCCGCAGAGGCGTCCGGCTGGTCACGTTCGACACCGCCGTGTCGGCCCTGGCCCAAGGACACGATGTGGAGC
TGCTGAGCACCCTCTGA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 7831.93 Da        Isoelectric Point: 4.5258

>AT36204 WP_083046150.1 NZ_AP022575:2506911-2507132 [Mycobacterium shinjukuense]
VRTTLDIADDVIAAAREIAFAERRSLGAVISELARRGLTPGRVEADDGLPVIRVPPGTPPITPDMVRRALDED

Download         Length: 222 bp

>AT36204 NZ_AP022575:2506911-2507132 [Mycobacterium shinjukuense]
GTGCGAACGACGCTGGACATCGCCGACGATGTCATCGCCGCAGCTCGCGAAATCGCCTTCGCCGAGCGCCGATCACTCGG
TGCGGTGATCTCCGAGCTCGCGCGCCGAGGTCTTACGCCGGGTCGTGTCGAAGCCGACGACGGGCTACCCGTGATCCGCG
TGCCGCCCGGGACCCCGCCGATCACACCCGACATGGTCCGCCGCGCGCTCGACGAGGACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References