Detailed information of TA system TA036192

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-PHD
• Location: 1999107..1999762
• Replicon: chromosome
• Accession: NZ_AP022575
• Organism: Mycobacterium shinjukuense strain JCM 14233

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: G6N20_RS08730
• Protein ID: WP_169715474.1
• Coordinates: 1999107..1999505 (-)
• Length: 133 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: G6N20_RS08735
• Protein ID: WP_083052271.1
• Coordinates: 1999502..1999762 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G6N20_RS08710	1997818..1998216	+	399	WP_083052270.1	ATPase	-
G6N20_RS20635	1998213..1998788	-	576	Protein_1723	hypothetical protein	-
G6N20_RS20785	1998777..1999085	-	309	Protein_1724	phosphoenolpyruvate carboxylase	-
G6N20_RS08730	1999107..1999505	-	399	WP_169715474.1	type II toxin-antitoxin system VapC family toxin	Toxin
G6N20_RS08735	1999502..1999762	-	261	WP_083052271.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
G6N20_RS08740	1999817..2000050	+	234	WP_040624202.1	preprotein translocase subunit SecG	-
G6N20_RS08745	2000066..2000851	-	786	WP_083052272.1	triose-phosphate isomerase	-
G6N20_RS08750	2000848..2002086	-	1239	WP_083052273.1	phosphoglycerate kinase	-
G6N20_RS08755	2002099..2003118	-	1020	WP_083052274.1	type I glyceraldehyde-3-phosphate dehydrogenase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (9-122)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-62)

Sequences

Toxin

Protein

• Length: 133 a.a.
• Molecular weight: 13667.57 Da
• Isoelectric Point: 4.5010

>T36192 WP_169715474.1 NZ_AP022575:c1999505-1999107 [Mycobacterium shinjukuense]
VTAAGVLATSVFIAHESGRQLDESRIPEEVATTVVTLAELNAGVLAAGSADVRAQRLATLDAIADMAALPVDVDAARTWA
RLCVHLAESGRRVRINDLWIAAVAASRGLPVVTQDGDFDALDGVAGVAILRV

Nucleotide

• Length: 399 bp

>T36192 NZ_AP022575:c1999505-1999107 [Mycobacterium shinjukuense]
GTGACGGCGGCGGGCGTGCTTGCTACGTCGGTGTTCATCGCGCATGAGAGCGGCCGGCAGCTCGACGAATCGCGGATTCC
TGAGGAAGTTGCGACGACGGTGGTCACGTTGGCTGAACTCAACGCCGGTGTTCTCGCGGCCGGCTCGGCGGATGTTCGAG
CGCAGCGGCTGGCGACGCTCGACGCGATCGCCGACATGGCGGCGCTTCCGGTCGACGTCGATGCGGCGCGGACATGGGCT
CGGCTGTGTGTTCACCTTGCCGAGTCGGGTCGCCGGGTCCGCATCAACGATCTGTGGATCGCCGCCGTTGCGGCTTCGCG
AGGGCTGCCCGTGGTGACCCAAGATGGCGACTTCGACGCGCTCGACGGTGTGGCCGGGGTAGCCATCCTTCGGGTCTGA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9597.00 Da
• Isoelectric Point: 12.0308

>AT36192 WP_083052271.1 NZ_AP022575:c1999762-1999502 [Mycobacterium shinjukuense]
MVEVASRELRNDTGRLLRRAQAGEDITVTVNGKPVALLTGLRPARRRWLSRNELLQRLRRAQADPGLRRDLAALAGDTTD
DLGPIR

Nucleotide

• Length: 261 bp

>AT36192 NZ_AP022575:c1999762-1999502 [Mycobacterium shinjukuense]
ATGGTTGAGGTGGCATCCCGCGAACTCCGCAACGACACTGGCCGGCTACTGCGGCGCGCGCAGGCCGGCGAAGACATCAC
CGTCACGGTCAACGGCAAGCCCGTGGCGCTGCTCACCGGATTGCGGCCGGCGCGGCGTCGATGGTTGAGCCGAAACGAGC
TGCTGCAGCGGCTTCGGCGCGCGCAGGCAGATCCGGGATTGCGCCGGGATCTTGCCGCGCTCGCGGGCGACACCACCGAC
GATCTGGGTCCGATCCGGTGA