Detailed information of TA system TA036191

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 1436845..1437526
• Replicon: chromosome
• Accession: NZ_AP022575
• Organism: Mycobacterium shinjukuense strain JCM 14233

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: G6N20_RS06410
• Protein ID: WP_083049054.1
• Coordinates: 1436845..1437282 (-)
• Length: 146 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: G6N20_RS06415
• Protein ID: WP_083049052.1
• Coordinates: 1437269..1437526 (-)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G6N20_RS06380	1432511..1432660	+	150	WP_158084763.1	hypothetical protein	-
G6N20_RS06385	1432901..1433377	+	477	WP_083049064.1	hypothetical protein	-
G6N20_RS06390	1433401..1434363	+	963	WP_083049061.1	FAD-binding oxidoreductase	-
G6N20_RS06395	1434398..1434826	-	429	WP_083049059.1	anti-sigma factor antagonist	-
G6N20_RS06400	1435049..1435450	-	402	WP_083049057.1	phage holin family protein	-
G6N20_RS06405	1435553..1436815	+	1263	WP_142272062.1	MFS transporter	-
G6N20_RS06410	1436845..1437282	-	438	WP_083049054.1	type II toxin-antitoxin system VapC family toxin	Toxin
G6N20_RS06415	1437269..1437526	-	258	WP_083049052.1	ribbon-helix-helix domain-containing protein	Antitoxin
G6N20_RS06420	1437563..1438855	-	1293	WP_083049049.1	competence/damage-inducible protein A	-
G6N20_RS06425	1438884..1440266	+	1383	WP_083049046.1	adenylate/guanylate cyclase domain-containing protein	-
G6N20_RS06430	1440320..1440637	+	318	WP_158084762.1	hypothetical protein	-
G6N20_RS06435	1440768..1441181	+	414	WP_142272061.1	hypothetical protein	-
G6N20_RS06440	1441178..1441546	+	369	WP_083049039.1	DUF5615 family PIN-like protein	-
G6N20_RS06445	1441584..1442078	+	495	WP_083049129.1	macro domain-containing protein	-
G6N20_RS06450	1442075..1442380	-	306	WP_083049038.1	MTH1187 family thiamine-binding protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain toxin (1-142)

Antitoxin

• Ribbon-helix-helix protein, CopG (2-38)

Sequences

Toxin

Protein

• Length: 146 a.a.
• Molecular weight: 16281.50 Da
• Isoelectric Point: 6.7550

>T36191 WP_083049054.1 NZ_AP022575:c1437282-1436845 [Mycobacterium shinjukuense]
MLCVDVNVVVYAHRADLPEHSHYRRLLEHLANGDQPLGLPDLALAGFVRVMTNRRIFAAPTSPTEAWRAVEGLLAAPAAM
QLRPGQRHWGLFRQLADDIDARGNDIADAYLAAYALENNATWLSADRGFARFNRLRWSHPLDLDI

Nucleotide

• Length: 438 bp

>T36191 NZ_AP022575:c1437282-1436845 [Mycobacterium shinjukuense]
ATGCTTTGCGTTGACGTCAACGTTGTCGTGTATGCGCACCGGGCGGACCTTCCCGAACATTCGCACTATCGGCGGCTGCT
TGAGCACCTGGCCAATGGCGACCAGCCGCTGGGCCTACCCGACCTGGCACTTGCCGGCTTCGTGCGGGTAATGACCAACC
GCCGGATCTTCGCCGCGCCGACGAGCCCGACCGAGGCGTGGCGGGCGGTCGAGGGCTTGCTTGCTGCGCCCGCAGCCATG
CAACTTCGGCCAGGACAGCGTCACTGGGGATTGTTTCGGCAGCTAGCTGACGACATCGACGCCCGCGGTAATGACATCGC
CGACGCATATTTGGCCGCCTACGCGCTGGAGAACAATGCGACCTGGCTCAGCGCGGACCGCGGCTTCGCACGATTCAACC
GACTGCGGTGGAGCCATCCGCTGGACCTCGACATCTGA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9068.18 Da
• Isoelectric Point: 9.9597

>AT36191 WP_083049052.1 NZ_AP022575:c1437526-1437269 [Mycobacterium shinjukuense]
VRTTIRIDDELYREVKMRAARSGRTVAAVLEDAVRRGLNPSDQRAGGRYTLRATGSGGLRPGVDLSSNAAIAEAMDEGAP
VDALR

Nucleotide

• Length: 258 bp

>AT36191 NZ_AP022575:c1437526-1437269 [Mycobacterium shinjukuense]
GTGCGCACGACGATCCGAATCGATGACGAGCTCTACCGCGAAGTGAAGATGCGGGCCGCTCGTTCGGGGCGCACCGTGGC
GGCGGTCCTGGAAGACGCGGTGCGCCGTGGTCTCAACCCGTCTGACCAACGTGCTGGAGGTCGCTACACGCTCCGGGCGA
CCGGTAGCGGAGGGCTTCGACCCGGGGTGGATCTGTCGTCCAACGCCGCAATCGCCGAGGCAATGGACGAAGGCGCACCG
GTCGATGCTTTGCGTTGA