36190

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1405089..1405651 Replicon chromosome
Accession NZ_AP022575
Organism Mycobacterium shinjukuense strain JCM 14233

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag G6N20_RS06225 Protein ID WP_083047838.1
Coordinates 1405322..1405651 (+) Length 110 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag G6N20_RS06220 Protein ID WP_083047924.1
Coordinates 1405089..1405325 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6N20_RS06175 1400284..1400682 + 399 WP_083047852.1 type II toxin-antitoxin system VapC family toxin -
G6N20_RS06185 1401216..1401650 + 435 WP_083047848.1 type II toxin-antitoxin system VapC family toxin -
G6N20_RS06190 1402145..1402567 - 423 WP_083047846.1 VapC toxin family PIN domain ribonuclease -
G6N20_RS06195 1402558..1402764 - 207 WP_083047844.1 DUF2191 domain-containing protein -
G6N20_RS06200 1403278..1403631 + 354 WP_142272002.1 hypothetical protein -
G6N20_RS06205 1403628..1404056 - 429 WP_083047840.1 cellulose-binding domain-containing protein -
G6N20_RS06210 1404347..1404709 - 363 WP_083047926.1 PIN domain-containing protein -
G6N20_RS06215 1404727..1404990 - 264 WP_142272001.1 hypothetical protein -
G6N20_RS06220 1405089..1405325 + 237 WP_083047924.1 DUF2191 domain-containing protein Antitoxin
G6N20_RS06225 1405322..1405651 + 330 WP_083047838.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
G6N20_RS06230 1405711..1407465 - 1755 WP_158084753.1 adenylate/guanylate cyclase domain-containing protein -
G6N20_RS06235 1407575..1408561 - 987 WP_083047833.1 pyridoxal-phosphate dependent enzyme -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(7-103)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 11625.65 Da        Isoelectric Point: 8.1274

>T36190 WP_083047838.1 NZ_AP022575:1405322-1405651 [Mycobacterium shinjukuense]
VSALPARGEVWWCEIAEIGRRPVVVLSRDAAIPRLRRALVAPCTTTIRGLASEVLLEPEVDPIPRRSAVNLDSVESVSIA
VLVGRLGRLADTRMRAICAALAVAVDCTG

Download         Length: 330 bp

>T36190 NZ_AP022575:1405322-1405651 [Mycobacterium shinjukuense]
GTGAGCGCACTGCCGGCACGCGGAGAGGTGTGGTGGTGTGAGATTGCCGAGATAGGTCGACGCCCGGTTGTGGTGCTGTC
GCGTGATGCGGCGATCCCTCGGCTACGACGCGCGCTCGTCGCTCCGTGCACCACGACCATCCGAGGGCTGGCAAGCGAGG
TTCTTCTTGAACCTGAGGTCGATCCGATCCCGCGGCGTTCGGCGGTGAATCTGGACTCGGTGGAAAGTGTCTCGATCGCA
GTGTTGGTCGGACGGCTGGGTCGCCTCGCCGACACCCGGATGCGCGCGATCTGCGCGGCCCTTGCGGTTGCAGTCGACTG
CACTGGCTGA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8433.33 Da        Isoelectric Point: 4.5238

>AT36190 WP_083047924.1 NZ_AP022575:1405089-1405325 [Mycobacterium shinjukuense]
MNRIRLSTTVDATLLRSARGLRVGITDAALIDEALGALLARYRSAEVDASYAAYDEHPADEPDEWGDLASWRRAAGAS

Download         Length: 237 bp

>AT36190 NZ_AP022575:1405089-1405325 [Mycobacterium shinjukuense]
ATGAACCGCATACGGTTGAGCACCACGGTTGACGCCACGCTATTGCGCAGTGCGCGCGGCCTGCGGGTAGGCATCACTGA
CGCCGCCCTCATCGATGAGGCTCTCGGTGCCTTGCTCGCTCGTTATCGGTCGGCCGAGGTGGACGCGAGCTACGCCGCCT
ACGACGAGCATCCGGCGGATGAGCCCGATGAGTGGGGCGATCTAGCATCGTGGCGGCGAGCCGCTGGGGCCTCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References