36189

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 1348198..1348790 Replicon chromosome
Accession NZ_AP022575
Organism Mycobacterium shinjukuense strain JCM 14233

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag G6N20_RS05955 Protein ID WP_083049904.1
Coordinates 1348392..1348790 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag G6N20_RS05950 Protein ID WP_083049906.1
Coordinates 1348198..1348395 (+) Length 66 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6N20_RS05925 1343272..1344609 + 1338 WP_179961545.1 RNA polymerase sigma factor SigC -
G6N20_RS05930 1344694..1345443 - 750 WP_083049911.1 SDR family NAD(P)-dependent oxidoreductase -
G6N20_RS05935 1345473..1345892 + 420 WP_142272098.1 F420-dependent biliverdin reductase -
G6N20_RS05940 1345939..1346787 + 849 WP_083049968.1 class A beta-lactamase -
G6N20_RS05945 1346860..1348137 + 1278 WP_142272102.1 class I SAM-dependent methyltransferase -
G6N20_RS05950 1348198..1348395 + 198 WP_083049906.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
G6N20_RS05955 1348392..1348790 + 399 WP_083049904.1 PIN domain nuclease Toxin
G6N20_RS05960 1348881..1349576 - 696 WP_163662842.1 dienelactone hydrolase family protein -
G6N20_RS05965 1349649..1350146 + 498 WP_083047920.1 FxsA family protein -
G6N20_RS05970 1350166..1351770 + 1605 WP_083047918.1 amidohydrolase -
G6N20_RS05975 1351763..1353616 + 1854 WP_142272004.1 apolipoprotein N-acyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-122)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(1-42)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14597.94 Da        Isoelectric Point: 6.4494

>T36189 WP_083049904.1 NZ_AP022575:1348392-1348790 [Mycobacterium shinjukuense]
VIVVDTSVWIDVLNGTPAPQAQRCVELIRSGEPVALTDVILTEVLQGLRSDREAALVERHLRAFPILRLQDLDDFVLSAR
LYRAARRAGVTIRKTLDCLIAAPCVRTGAPLLHADEDFDRLASCTPLRIWTG

Download         Length: 399 bp

>T36189 NZ_AP022575:1348392-1348790 [Mycobacterium shinjukuense]
GTGATTGTCGTCGACACGAGCGTATGGATTGACGTCCTGAATGGCACCCCCGCCCCACAGGCCCAACGCTGTGTCGAGCT
GATCCGATCGGGCGAACCTGTCGCGCTCACCGACGTCATCCTGACCGAGGTGCTGCAGGGGCTGCGGTCGGATCGGGAGG
CGGCGCTGGTCGAGCGTCATTTGCGCGCCTTCCCGATCCTGCGGCTGCAGGACCTTGATGATTTCGTGCTCTCGGCCAGG
CTGTACCGGGCGGCACGACGCGCCGGCGTGACCATCCGTAAGACGTTGGACTGTTTGATCGCCGCTCCCTGCGTGCGTAC
CGGTGCCCCGCTGCTGCACGCCGACGAGGATTTCGATCGCCTCGCCAGCTGCACGCCGCTTCGGATCTGGACGGGTTGA

Antitoxin


Download         Length: 66 a.a.        Molecular weight: 7520.53 Da        Isoelectric Point: 11.1986

>AT36189 WP_083049906.1 NZ_AP022575:1348198-1348395 [Mycobacterium shinjukuense]
MRTNIDIDDDVLREAQRLVGTRTKRDTVNLALRELVARHRQIGVLDLRGKVHWDGDLAESRRGRS

Download         Length: 198 bp

>AT36189 NZ_AP022575:1348198-1348395 [Mycobacterium shinjukuense]
ATGCGGACGAATATCGACATCGACGACGACGTTTTGCGCGAGGCCCAGCGCCTGGTTGGGACGCGGACGAAGCGCGATAC
CGTCAATCTGGCACTGCGTGAACTGGTCGCCCGGCATCGCCAGATCGGCGTGCTTGACCTGCGCGGGAAGGTGCATTGGG
ACGGAGACCTGGCTGAGAGTCGTCGTGGCCGGTCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References