Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 1318088..1318861 Replicon chromosome
Accession NZ_AP022575
Organism Mycobacterium shinjukuense strain JCM 14233

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag G6N20_RS05805 Protein ID WP_083049951.1
Coordinates 1318427..1318861 (+) Length 145 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag G6N20_RS05800 Protein ID WP_083049978.1
Coordinates 1318088..1318342 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6N20_RS05780 1314482..1314676 + 195 WP_083049979.1 ubiquitin-like protein Pup -
G6N20_RS05785 1314673..1315566 + 894 WP_083049957.1 proteasome subunit beta -
G6N20_RS05790 1315563..1316357 + 795 WP_083049955.1 proteasome subunit alpha -
G6N20_RS05795 1316501..1318030 + 1530 WP_083049953.1 PE family protein -
G6N20_RS05800 1318088..1318342 + 255 WP_083049978.1 antitoxin Antitoxin
G6N20_RS05805 1318427..1318861 + 435 WP_083049951.1 type II toxin-antitoxin system VapC family toxin Toxin
G6N20_RS05810 1318888..1320432 - 1545 WP_083049949.1 HNH endonuclease -
G6N20_RS05815 1320559..1321917 + 1359 WP_142272100.1 Pup--protein ligase -
G6N20_RS05820 1321936..1322934 + 999 WP_083049945.1 YafY family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-141)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 145 a.a.        Molecular weight: 15497.70 Da        Isoelectric Point: 6.4864

>T36188 WP_083049951.1 NZ_AP022575:1318427-1318861 [Mycobacterium shinjukuense]
MKIVDANVLLYAVNTASEHHRPSLRWLDGALSGGDSIGFAWVPLLAFVRLVTRPGLFPRPLSPEDAIGQVADWLTAPSAV
LVNPTARHADILARMLTQVGAGANLVNDAHLAALAVEHRASIVSYDSDFGRFGDVRWDHPSALL

Download         Length: 435 bp

>T36188 NZ_AP022575:1318427-1318861 [Mycobacterium shinjukuense]
ATGAAAATCGTCGACGCCAATGTCCTGCTGTATGCGGTCAATACCGCCAGCGAACACCACCGTCCGTCCCTGCGCTGGCT
CGACGGCGCGCTATCCGGTGGCGACAGCATCGGATTCGCATGGGTCCCGTTGTTGGCGTTTGTGCGGCTAGTGACCCGGC
CGGGGTTGTTCCCCCGCCCGCTGTCTCCGGAGGACGCGATTGGTCAGGTTGCCGACTGGCTGACCGCACCGAGCGCGGTA
TTGGTGAATCCGACCGCCCGCCACGCCGACATCCTGGCGAGAATGCTGACACAGGTGGGAGCTGGCGCCAACCTCGTCAA
CGACGCTCACCTGGCCGCGCTCGCCGTCGAGCATCGCGCCAGCATTGTGTCCTACGACAGCGATTTCGGCCGATTCGGCG
ACGTGCGCTGGGATCACCCGTCGGCGCTGCTGTGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9505.73 Da        Isoelectric Point: 11.1401

>AT36188 WP_083049978.1 NZ_AP022575:1318088-1318342 [Mycobacterium shinjukuense]
MRTTVTLDDDVEQLVRRRMAERQVSFKKALNDAIRDGASGRPAPRRFSTRTADLGVPAVNLDRALQLAADIEDEELVRRQ
RRGS

Download         Length: 255 bp

>AT36188 NZ_AP022575:1318088-1318342 [Mycobacterium shinjukuense]
ATGCGGACGACGGTGACGTTGGACGACGACGTCGAGCAGTTGGTGCGGCGCCGGATGGCCGAGCGGCAGGTGTCCTTCAA
GAAAGCCCTCAACGACGCGATTCGAGACGGCGCCTCCGGCCGGCCCGCGCCACGCCGGTTCAGCACGCGCACGGCAGACT
TGGGTGTCCCCGCGGTCAATCTCGACCGGGCCTTGCAGCTTGCGGCCGACATCGAGGACGAGGAACTCGTGCGTCGTCAG
CGGCGCGGGTCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References