Detailed information of TA system TA036187

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /BrnT(toxin)
• Location: 659285..659717
• Replicon: chromosome
• Accession: NZ_AP022575
• Organism: Mycobacterium shinjukuense strain JCM 14233

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: G6N20_RS02975
• Protein ID: WP_083051539.1
• Coordinates: 659285..659491 (+)
• Length: 69 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: G6N20_RS02980
• Protein ID: WP_083051536.1
• Coordinates: 659481..659717 (+)
• Length: 79 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G6N20_RS02945	654682..656007	+	1326	WP_083051551.1	dipeptidase	-
G6N20_RS02950	656008..656481	-	474	WP_083051548.1	thioredoxin-dependent thiol peroxidase	-
G6N20_RS02955	656595..656822	+	228	WP_083051545.1	DUF3618 domain-containing protein	-
G6N20_RS02965	657224..658423	+	1200	WP_083051542.1	L,D-transpeptidase family protein	-
G6N20_RS02975	659285..659491	+	207	WP_083051539.1	BrnT family toxin	Toxin
G6N20_RS02980	659481..659717	+	237	WP_083051536.1	CopG family transcriptional regulator	Antitoxin
G6N20_RS02985	659916..661346	-	1431	Protein_588	IS3 family transposase	-
G6N20_RS02990	662052..662612	-	561	WP_083049645.1	TetR family transcriptional regulator	-
G6N20_RS02995	662609..662932	-	324	WP_083049663.1	multidrug efflux SMR transporter	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	659916..660329	413

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Ribonuclease toxin, BrnT, of type II toxin-antitoxin system (1-62)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 69 a.a.
• Molecular weight: 7842.88 Da
• Isoelectric Point: 6.4644

>T36187 WP_083051539.1 NZ_AP022575:659285-659491 [Mycobacterium shinjukuense]
IDVTEAQILWRDTHRIEVPARTTAEPRWMVIGEIGGRVWSAAGTYRDEHVRIIAVRPSREREVALYEG

Nucleotide

• Length: 207 bp

>T36187 NZ_AP022575:659285-659491 [Mycobacterium shinjukuense]
ATCGACGTCACCGAGGCGCAGATACTGTGGCGGGATACGCATCGGATCGAGGTCCCGGCACGGACGACAGCTGAGCCGAG
GTGGATGGTGATCGGTGAGATCGGCGGCCGGGTTTGGTCGGCGGCGGGGACCTATCGTGACGAACACGTCCGGATCATCG
CGGTACGCCCGTCCCGAGAGCGCGAGGTGGCACTTTATGAAGGCTAA

Antitoxin

Protein

• Length: 79 a.a.
• Molecular weight: 8723.79 Da
• Isoelectric Point: 6.4691

>AT36187 WP_083051536.1 NZ_AP022575:659481-659717 [Mycobacterium shinjukuense]
MKAKEFDGRFDAGEDMAAALDTARARRPGEEHRRVNGDFPAWMIAELDREATRLGVTRQSLIKVWTAEKLDQGSHPAA

Nucleotide

• Length: 237 bp

>AT36187 NZ_AP022575:659481-659717 [Mycobacterium shinjukuense]
ATGAAGGCTAAGGAATTCGACGGGAGGTTCGACGCCGGTGAGGACATGGCGGCCGCTTTGGATACGGCGCGGGCGCGCCG
CCCCGGCGAGGAACACCGTCGGGTGAACGGTGACTTCCCGGCTTGGATGATCGCCGAACTCGACCGCGAGGCAACCCGCC
TCGGAGTCACTCGCCAGTCACTCATCAAGGTCTGGACCGCCGAGAAACTCGACCAAGGCAGTCACCCCGCCGCTTGA