Detailed information of TA system TA036186

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PhRel-ATphRel/-
• Location: 632822..633845
• Replicon: chromosome
• Accession: NZ_AP022575
• Organism: Mycobacterium shinjukuense strain JCM 14233

Toxin (Protein)

• Gene name: phRel
• Uniprot ID: -
• Locus tag: G6N20_RS02880
• Protein ID: WP_083050667.1
• Coordinates: 632822..633616 (+)
• Length: 265 a.a.

Antitoxin (Protein)

• Gene name: ATphRel
• Uniprot ID: -
• Locus tag: G6N20_RS02885
• Protein ID: WP_083050670.1
• Coordinates: 633609..633845 (+)
• Length: 79 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G6N20_RS02855	627874..629838	-	1965	WP_083050656.1	SpoIIE family protein phosphatase	-
G6N20_RS02860	629975..630361	-	387	WP_083050688.1	anti-sigma factor antagonist	-
G6N20_RS02865	630628..631560	+	933	WP_158084785.1	hypothetical protein	-
G6N20_RS02870	631715..632341	-	627	WP_083050661.1	zeta toxin family protein	-
G6N20_RS02875	632342..632698	-	357	WP_083050664.1	type II toxin-antitoxin system prevent-host-death family antitoxin	-
G6N20_RS02880	632822..633616	+	795	WP_083050667.1	hypothetical protein	Toxin
G6N20_RS02885	633609..633845	+	237	WP_083050670.1	hypothetical protein	Antitoxin
G6N20_RS02890	634192..635448	+	1257	WP_163662793.1	HNH endonuclease	-
G6N20_RS02895	635476..636378	-	903	WP_163662796.1	IS30 family transposase	-
G6N20_RS02900	636680..636970	+	291	WP_158084797.1	hypothetical protein	-
G6N20_RS02905	637325..637564	-	240	WP_083051575.1	ribbon-helix-helix domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RelA/SpoT (75-173)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 265 a.a.
• Molecular weight: 28805.51 Da
• Isoelectric Point: 4.9221

>T36186 WP_083050667.1 NZ_AP022575:632822-633616 [Mycobacterium shinjukuense]
VGVALVGSEIVDLASRPPWSNNAVRRLGAALRDGVDPPIDRPSYAEVMVWHADLAAEVQAQVEGGSWSIASELLVTSRAK
TQDTLVAKLRRQPNLQLNTIQDLAGVRIDADLLLGEQTRLAREVANHFGADESAIHDLRDHPHAGYRAVHVWLRLPAGRV
EIQIRTILQSLWANCYERLADAYGRGILYGEPIERLATSGVGPAQLPEPVRVMQDASAKLAMHEAEWQQCAEIEDPGQRA
TVLATIKSRLEGAIDQAESEIEGG

Nucleotide

• Length: 795 bp

>T36186 NZ_AP022575:632822-633616 [Mycobacterium shinjukuense]
GTGGGGGTAGCACTCGTAGGCTCGGAAATTGTGGATCTGGCTTCGCGACCACCGTGGTCGAACAACGCGGTGCGTCGTCT
CGGCGCGGCACTGCGCGACGGAGTCGATCCGCCGATCGACCGTCCGTCATACGCCGAGGTGATGGTGTGGCATGCAGACT
TGGCCGCCGAGGTGCAGGCCCAGGTTGAGGGCGGGAGCTGGTCGATTGCGTCGGAGCTACTGGTCACCTCGCGAGCCAAG
ACCCAAGACACCCTGGTAGCAAAGTTGCGGCGCCAGCCCAACCTGCAACTGAACACCATCCAAGACCTCGCCGGTGTCCG
CATCGATGCCGACTTACTGTTGGGCGAGCAGACGAGACTTGCCCGTGAGGTCGCCAATCACTTCGGTGCCGACGAGTCGG
CGATTCATGATCTGCGTGATCACCCGCACGCCGGTTACCGGGCCGTCCATGTCTGGCTTCGGTTGCCTGCGGGTCGTGTC
GAGATACAGATTCGGACCATCTTGCAGAGCTTGTGGGCCAACTGCTACGAGCGTCTCGCTGACGCGTACGGCCGCGGCAT
CCTCTATGGCGAACCGATCGAGCGGTTGGCAACTTCTGGCGTTGGCCCGGCGCAGCTTCCGGAGCCGGTACGGGTTATGC
AAGACGCGTCGGCGAAACTGGCGATGCATGAGGCCGAGTGGCAGCAGTGCGCTGAGATCGAAGATCCCGGTCAGCGGGCG
ACGGTGCTGGCCACGATCAAGTCGAGGCTGGAAGGGGCCATCGATCAGGCCGAGTCAGAAATCGAAGGTGGGTGA

Antitoxin

Protein

• Length: 79 a.a.
• Molecular weight: 8787.79 Da
• Isoelectric Point: 7.3179

>AT36186 WP_083050670.1 NZ_AP022575:633609-633845 [Mycobacterium shinjukuense]
VGDVAGYVVEYDRRTHARRITEFATPRAAMEHRLKLEAERTDRNVEVVALVSTSLDTLKQTHSRYFAGDELNVGNGAR

Nucleotide

• Length: 237 bp

>AT36186 NZ_AP022575:633609-633845 [Mycobacterium shinjukuense]
GTGGGTGACGTGGCCGGTTATGTCGTCGAGTACGACCGGCGCACCCACGCGCGTCGCATCACCGAGTTCGCCACCCCGCG
TGCGGCGATGGAGCACCGGCTGAAGCTGGAAGCCGAGCGCACCGACCGGAACGTCGAAGTCGTTGCGCTCGTTAGTACGT
CACTGGACACCCTGAAGCAAACCCATTCGCGGTACTTCGCGGGTGACGAGCTGAACGTCGGAAACGGCGCGCGGTAG