36185

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 345269..345849 Replicon chromosome
Accession NZ_AP022575
Organism Mycobacterium shinjukuense strain JCM 14233

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag G6N20_RS01555 Protein ID WP_083051320.1
Coordinates 345460..345849 (+) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag G6N20_RS01550 Protein ID WP_083051367.1
Coordinates 345269..345463 (+) Length 65 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6N20_RS01530 340925..341548 - 624 WP_083051330.1 lipid droplet-associated protein -
G6N20_RS01535 341638..342636 + 999 WP_083051327.1 4-hydroxy-3-methylbut-2-enyl diphosphate reductase -
G6N20_RS01540 342639..343841 - 1203 WP_179961505.1 hypothetical protein -
G6N20_RS01545 343970..345061 + 1092 WP_083051323.1 redox-regulated ATPase YchF -
G6N20_RS01550 345269..345463 + 195 WP_083051367.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
G6N20_RS01555 345460..345849 + 390 WP_083051320.1 type II toxin-antitoxin system VapC family toxin Toxin
G6N20_RS01560 346429..346911 + 483 WP_163663193.1 C40 family peptidase -
G6N20_RS01565 347028..347351 + 324 WP_083051315.1 antibiotic biosynthesis monooxygenase -
G6N20_RS01570 347388..349166 - 1779 WP_083051313.1 PE-PPE domain-containing protein -
G6N20_RS01575 349286..349981 - 696 WP_083051310.1 guanylate cyclase -
G6N20_RS01580 350014..350223 + 210 WP_083051308.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Bacterial antitoxin of type II TA system, VapB

(1-42)


Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 14313.57 Da        Isoelectric Point: 6.3252

>T36185 WP_083051320.1 NZ_AP022575:345460-345849 [Mycobacterium shinjukuense]
VILVDTAIWIDHLRAGESRLVDLLSDDDAGCHPLVIEEMALGSIRQRDVVLDLLANLYQFPTVTHPEVLHLIDRRRLWGR
GLSAVDLHLLGSVALVVGAGLWTRDKRLKAACADVGVPLFDEGKYRQRG

Download         Length: 390 bp

>T36185 NZ_AP022575:345460-345849 [Mycobacterium shinjukuense]
GTGATTCTGGTCGACACCGCGATCTGGATCGACCATCTGCGTGCCGGCGAATCGCGCCTCGTCGACCTGTTAAGCGATGA
CGATGCGGGCTGTCATCCCCTGGTCATCGAGGAGATGGCGCTCGGCTCGATCAGGCAACGTGATGTCGTGCTCGACTTGC
TGGCCAACCTTTACCAGTTCCCGACGGTGACCCACCCCGAGGTTCTGCATCTCATTGATCGGCGGCGGCTGTGGGGGCGT
GGTTTAAGCGCCGTCGATCTGCATTTGCTCGGCTCGGTGGCTCTGGTTGTCGGGGCGGGGCTGTGGACACGAGACAAGCG
ATTGAAGGCTGCCTGTGCCGACGTCGGCGTGCCGTTGTTCGATGAAGGTAAATACCGACAACGGGGGTGA

Antitoxin


Download         Length: 65 a.a.        Molecular weight: 6731.70 Da        Isoelectric Point: 11.9732

>AT36185 WP_083051367.1 NZ_AP022575:345269-345463 [Mycobacterium shinjukuense]
MRTTVTIDDALLAKAAELTGVSENGALLRQGLQTLIRVESGRRLAALGGTDTQATAAPRRRAAR

Download         Length: 195 bp

>AT36185 NZ_AP022575:345269-345463 [Mycobacterium shinjukuense]
ATGAGGACGACGGTCACGATCGATGACGCCCTGTTGGCCAAGGCCGCCGAGTTGACCGGGGTGAGCGAAAATGGCGCGCT
GCTGCGTCAGGGATTGCAGACGCTGATCCGGGTGGAGAGCGGTCGTCGGCTGGCGGCTCTCGGCGGAACGGACACCCAGG
CGACGGCTGCTCCACGACGGAGAGCCGCGCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References