Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PemK-MazE
Location 3497863..3498398 Replicon chromosome
Accession NZ_AP022574
Organism Mycolicibacterium psychrotolerans strain JCM 13323

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag G6N45_RS17095 Protein ID WP_163723335.1
Coordinates 3497863..3498195 (-) Length 111 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag G6N45_RS17100 Protein ID WP_163723336.1
Coordinates 3498192..3498398 (-) Length 69 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6N45_RS17090 3496265..3497647 + 1383 WP_179965192.1 2-polyprenyl-6-methoxyphenol hydroxylase-like oxidoreductase -
G6N45_RS17095 3497863..3498195 - 333 WP_163723335.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
G6N45_RS17100 3498192..3498398 - 207 WP_163723336.1 DUF3018 family protein Antitoxin
G6N45_RS17105 3498619..3498930 - 312 WP_163723337.1 type II toxin-antitoxin system PemK/MazF family toxin -
G6N45_RS17110 3498920..3499153 - 234 WP_163723338.1 hypothetical protein -
G6N45_RS17115 3499301..3499546 + 246 WP_163723339.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
G6N45_RS17120 3499543..3499932 + 390 WP_163723340.1 type II toxin-antitoxin system VapC family toxin -
G6N45_RS27730 3500017..3500163 - 147 WP_170312453.1 hypothetical protein -
G6N45_RS17125 3500327..3500683 - 357 WP_163723341.1 VOC family protein -
G6N45_RS17130 3500834..3501676 + 843 WP_163723342.1 alpha/beta hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 3489196..3504496 15300


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-108)

Antitoxin

Antitoxin MazE-like

(4-66)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 11817.69 Da        Isoelectric Point: 8.7287

>T36183 WP_163723335.1 NZ_AP022574:c3498195-3497863 [Mycolicibacterium psychrotolerans]
VNRGEIWTVAGGVYATKPRPAVIVQDDLFAATSSVTVAPMSSTLLDAPLMRIRIAGGDGRLSGLDHDSDVMIDKLTTVKR
SNVHVRVGRLTAEQVVEVERAMMAFLGLAR

Download         Length: 333 bp

>T36183 NZ_AP022574:c3498195-3497863 [Mycolicibacterium psychrotolerans]
GTGAACAGAGGGGAGATCTGGACCGTAGCGGGGGGCGTCTACGCGACCAAGCCGCGTCCCGCGGTGATTGTTCAGGATGA
CCTCTTTGCTGCCACGAGTTCAGTAACTGTTGCTCCCATGTCCAGCACGCTGTTGGATGCACCGTTGATGCGCATCCGGA
TTGCCGGCGGAGACGGCCGGTTGTCCGGACTTGATCACGACAGTGACGTGATGATCGACAAGCTCACAACCGTCAAAAGG
TCGAATGTCCACGTCCGGGTTGGCCGGCTGACAGCGGAGCAAGTCGTCGAGGTCGAACGGGCGATGATGGCATTCCTCGG
CCTTGCGCGATAG

Antitoxin


Download         Length: 69 a.a.        Molecular weight: 7886.74 Da        Isoelectric Point: 4.8228

>AT36183 WP_163723336.1 NZ_AP022574:c3498398-3498192 [Mycolicibacterium psychrotolerans]
MAVRERVGEYRRRMRERGLRPLQVWVPDVRTESFAAEAHRQASLVARAGESSDDQDFIEAISAPWDEE

Download         Length: 207 bp

>AT36183 NZ_AP022574:c3498398-3498192 [Mycolicibacterium psychrotolerans]
ATGGCGGTGAGAGAAAGGGTCGGCGAGTACCGACGGCGGATGCGGGAGCGCGGCCTGCGGCCGCTGCAGGTCTGGGTGCC
CGACGTGCGGACTGAGAGTTTTGCCGCCGAGGCGCATCGTCAGGCTTCGTTGGTCGCACGAGCAGGCGAAAGCTCCGATG
ACCAGGACTTCATTGAGGCCATCTCGGCGCCATGGGACGAGGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References