Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Fic(toxin)
Location 76253..76830 Replicon chromosome
Accession NZ_AP022574
Organism Mycolicibacterium psychrotolerans strain JCM 13323

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag G6N45_RS00305 Protein ID WP_057151345.1
Coordinates 76253..76636 (-) Length 128 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag G6N45_RS00310 Protein ID WP_163719713.1
Coordinates 76633..76830 (-) Length 66 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6N45_RS00290 72045..74969 + 2925 WP_163719707.1 serine/threonine-protein kinase -
G6N45_RS00295 74962..75567 - 606 WP_163719709.1 FHA domain-containing protein -
G6N45_RS00300 75661..76041 - 381 WP_163719711.1 hypothetical protein -
G6N45_RS00305 76253..76636 - 384 WP_057151345.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
G6N45_RS00310 76633..76830 - 198 WP_163719713.1 antitoxin Phd Antitoxin
G6N45_RS00315 76867..78015 - 1149 WP_163719715.1 serine hydrolase -
G6N45_RS00320 78258..79265 + 1008 WP_163719716.1 alpha/beta hydrolase -
G6N45_RS00325 79313..80800 + 1488 WP_163727532.1 MFS transporter -
G6N45_RS00330 80763..81656 - 894 WP_163719718.1 slipin family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(24-83)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 128 a.a.        Molecular weight: 13656.26 Da        Isoelectric Point: 4.0503

>T36182 WP_057151345.1 NZ_AP022574:c76636-76253 [Mycolicibacterium psychrotolerans]
VTEYLDRDDVLVAGAAAVGIEVRVADYGLLDAAVARPQATAFGIDAYPDLFTKAAALLQSLARNHALVDGNKRTAWAAAW
TFLSINGTQLDPNFDVDDAEIFMNDVAVQGDLDIRRVADKLQSYAEA

Download         Length: 384 bp

>T36182 NZ_AP022574:c76636-76253 [Mycolicibacterium psychrotolerans]
GTGACCGAGTACCTGGACCGCGACGATGTCCTGGTCGCCGGAGCGGCGGCGGTGGGAATCGAAGTGCGGGTGGCCGACTA
CGGGCTTCTCGATGCGGCGGTGGCCCGACCGCAGGCCACCGCCTTCGGCATCGACGCTTATCCCGACCTGTTCACCAAGG
CCGCGGCGCTGCTGCAGTCGTTGGCTCGCAACCACGCGTTGGTCGACGGGAACAAACGCACCGCCTGGGCTGCCGCGTGG
ACGTTCCTGTCCATCAACGGCACGCAGCTGGATCCGAACTTCGATGTCGACGACGCCGAGATCTTCATGAATGACGTTGC
TGTGCAGGGAGATCTGGACATCCGCCGGGTAGCGGACAAGCTACAGAGTTACGCGGAGGCGTAG

Antitoxin


Download         Length: 66 a.a.        Molecular weight: 7267.25 Da        Isoelectric Point: 9.1311

>AT36182 WP_163719713.1 NZ_AP022574:c76830-76633 [Mycolicibacterium psychrotolerans]
MPALNINFTDEEMEQLRTAAAAGEMSLRAFVQRAALDAASDHKRRVREAARIVAERSAELNRRLA

Download         Length: 198 bp

>AT36182 NZ_AP022574:c76830-76633 [Mycolicibacterium psychrotolerans]
ATGCCGGCGTTGAACATCAATTTCACCGACGAGGAAATGGAACAGTTGCGCACGGCGGCGGCCGCAGGGGAGATGTCGCT
GCGCGCGTTCGTGCAACGTGCCGCCCTCGACGCCGCCTCGGATCACAAGCGCCGCGTGCGCGAGGCTGCGCGGATCGTCG
CCGAGCGCAGTGCAGAGCTCAACCGCCGCCTGGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References