Detailed information of TA system TA036177

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mbcAT/RES-Xre
• Location: 61049..61947
• Replicon: plasmid pJCM12603
• Accession: NZ_AP022571
• Organism: Mycolicibacterium poriferae strain JCM 12603

Toxin (Protein)

• Gene name: mbcT
• Uniprot ID: -
• Locus tag: G6N39_RS27330
• Protein ID: WP_163681054.1
• Coordinates: 61049..61609 (-)
• Length: 187 a.a.

Antitoxin (Protein)

• Gene name: mbcA
• Uniprot ID: -
• Locus tag: G6N39_RS27335
• Protein ID: WP_163681057.1
• Coordinates: 61606..61947 (-)
• Length: 114 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G6N39_RS27310	57699..57989	-	291	WP_083775475.1	WhiB family transcriptional regulator	-
G6N39_RS27315	58201..58914	+	714	WP_170311246.1	transcriptional regulator	-
G6N39_RS27320	59002..59312	+	311	Protein_63	thermonuclease family protein	-
G6N39_RS27325	59534..60664	+	1131	WP_163681051.1	lytic transglycosylase	-
G6N39_RS27330	61049..61609	-	561	WP_163681054.1	RES domain-containing protein	Toxin
G6N39_RS27335	61606..61947	-	342	WP_163681057.1	DUF2384 domain-containing protein	Antitoxin
G6N39_RS27340	62034..62328	+	295	Protein_67	hypothetical protein	-
G6N39_RS27345	62346..63185	+	840	WP_163681060.1	hypothetical protein	-
G6N39_RS27350	63300..63533	+	234	WP_163681064.1	DUF2188 domain-containing protein	-
G6N39_RS27355	63620..64027	-	408	WP_163681067.1	hypothetical protein	-
G6N39_RS27360	64313..64621	+	309	WP_163681069.1	hypothetical protein	-
G6N39_RS27365	64773..66089	+	1317	WP_163681267.1	L,D-transpeptidase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..216341	216341

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RES domain (27-148)

Antitoxin

• Antitoxin Xre/MbcA/ParS-like, toxin-binding domain (69-110)

Sequences

Toxin

Protein

• Length: 187 a.a.
• Molecular weight: 20421.80 Da
• Isoelectric Point: 5.2414

>T36177 WP_163681054.1 NZ_AP022571:c61609-61049 [Mycolicibacterium poriferae]
VSDALDEDLVQRIDSRGTIQWSGTCFRYTGAQRDPLSGEGARRFGGRWNPPLLFSAIYLADSAQACMVEVERAAQAASTT
PEGMLEAHYRLHTIDATHMAVLDLTTSEAREAVGLEDDDIYGDDWSACQAVGHAAWFLHVQGVLVPAAGGVGLVITAYEQ
RTRPGQLRISHSEDLTPTRYRKLRHP

Nucleotide

• Length: 561 bp

>T36177 NZ_AP022571:c61609-61049 [Mycolicibacterium poriferae]
GTGAGCGATGCGCTCGACGAGGATCTGGTGCAGCGCATCGACTCGCGTGGCACCATCCAGTGGTCGGGAACGTGCTTCCG
GTACACCGGCGCCCAACGTGATCCTCTATCAGGGGAGGGGGCGCGTAGATTCGGCGGCAGGTGGAACCCGCCCCTGTTGT
TCTCGGCGATCTATCTGGCCGATTCCGCGCAAGCATGCATGGTTGAAGTGGAGCGCGCCGCCCAGGCGGCATCAACGACC
CCCGAGGGAATGCTCGAAGCCCACTACCGGCTGCACACCATCGACGCAACCCATATGGCGGTCCTTGATCTCACCACCTC
CGAAGCCCGCGAAGCGGTGGGGCTCGAAGACGACGACATCTACGGCGACGACTGGTCGGCCTGCCAAGCAGTGGGCCATG
CCGCATGGTTTCTGCACGTACAAGGCGTCCTCGTGCCCGCGGCCGGCGGGGTCGGCCTGGTCATCACCGCCTACGAACAA
CGCACCCGCCCCGGCCAGCTCCGCATCAGTCACAGCGAAGATTTGACACCCACCCGCTACCGGAAACTACGGCACCCGTG
A

Antitoxin

Protein

• Length: 114 a.a.
• Molecular weight: 12251.03 Da
• Isoelectric Point: 5.0916

>AT36177 WP_163681057.1 NZ_AP022571:c61947-61606 [Mycolicibacterium poriferae]
MGANALASTVSSAIERLGLTYEEVGGIVDASARSVARWTSGQVVPQRLNKQRLIELAYVADALAEVLPRDQANVWMFSPN
RLLAHGKPADLVRDGEYQRVLALIDAMAEGIFV

Nucleotide

• Length: 342 bp

>AT36177 NZ_AP022571:c61947-61606 [Mycolicibacterium poriferae]
ATGGGAGCTAATGCGCTCGCCTCGACCGTGTCGAGTGCGATCGAGCGCTTGGGATTGACTTACGAGGAGGTCGGCGGCAT
CGTCGATGCCTCGGCGCGCTCAGTAGCGCGCTGGACCTCAGGTCAGGTCGTCCCGCAACGCCTCAACAAACAACGACTCA
TCGAACTGGCCTACGTCGCCGACGCGCTGGCCGAAGTGCTCCCCCGCGACCAGGCCAACGTCTGGATGTTCTCGCCGAAT
CGACTACTGGCGCACGGCAAGCCCGCCGACCTGGTACGCGACGGCGAATATCAGCGCGTCTTAGCCCTCATCGACGCCAT
GGCCGAGGGGATCTTCGTGTGA