Detailed information of TA system TA036174

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/MazF(toxin)
• Location: 2071407..2071981
• Replicon: chromosome
• Accession: NZ_AP022570
• Organism: Mycolicibacterium poriferae strain JCM 12603

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: -
• Locus tag: G6N39_RS09870
• Protein ID: WP_163673446.1
• Coordinates: 2071407..2071748 (-)
• Length: 114 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: -
• Locus tag: G6N39_RS09875
• Protein ID: WP_163673447.1
• Coordinates: 2071745..2071981 (-)
• Length: 79 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G6N39_RS09840	2066413..2067066	+	654	WP_163673442.1	undecaprenyl diphosphate synthase family protein	-
G6N39_RS09845	2067075..2068472	+	1398	WP_163673443.1	FAD-dependent oxidoreductase	-
G6N39_RS09850	2068538..2068774	+	237	WP_152516161.1	antitoxin	-
G6N39_RS09855	2068887..2069549	-	663	WP_163673444.1	GtrA family protein	-
G6N39_RS09860	2069692..2070852	+	1161	WP_163680021.1	5-(carboxyamino)imidazole ribonucleotide synthase	-
G6N39_RS09865	2070849..2071349	+	501	WP_179967588.1	5-(carboxyamino)imidazole ribonucleotide mutase	-
G6N39_RS09870	2071407..2071748	-	342	WP_163673446.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
G6N39_RS09875	2071745..2071981	-	237	WP_163673447.1	DUF2191 domain-containing protein	Antitoxin
G6N39_RS09880	2072066..2072749	-	684	WP_163673448.1	GntR family transcriptional regulator	-
G6N39_RS09885	2072835..2073617	+	783	WP_163673449.1	4-hydroxy-2-oxovalerate aldolase	-
G6N39_RS09890	2073614..2074411	+	798	WP_163673450.1	carbon-nitrogen hydrolase family protein	-
G6N39_RS09895	2074413..2075483	+	1071	WP_163673451.1	TRAP transporter substrate-binding protein DctP	-
G6N39_RS09900	2075480..2075998	+	519	WP_163673452.1	TRAP transporter small permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	2016606..2072014	55408

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• mRNA interferase PemK-like (3-105)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 114 a.a.
• Molecular weight: 12308.27 Da
• Isoelectric Point: 7.5993

>T36174 WP_163673446.1 NZ_AP022570:c2071748-2071407 [Mycolicibacterium poriferae]
VNTVPQRGEMWWCELPEIGRRPVVVLSRDAAIPRLRRALVGPCTTNVRGLASEVVLDPDTDPVPRRSAVNLDSVESVSIG
VLVDRIGRLAESRMREICSALAIAVACDPPPTR

Nucleotide

• Length: 342 bp

>T36174 NZ_AP022570:c2071748-2071407 [Mycolicibacterium poriferae]
GTGAACACCGTTCCTCAGCGGGGCGAAATGTGGTGGTGCGAACTACCCGAGATCGGTCGACGACCCGTCGTCGTTCTCTC
GCGTGACGCCGCGATACCCCGGCTGCGAAGAGCGCTCGTCGGGCCATGCACCACGAACGTCCGAGGGTTGGCCAGCGAGG
TCGTGCTCGACCCTGACACAGACCCGGTCCCTCGCCGGTCTGCGGTCAATCTTGATTCGGTGGAAAGCGTCTCTATCGGT
GTTCTGGTCGACCGAATCGGACGCCTCGCCGAAAGCCGAATGCGCGAAATCTGCTCAGCCCTCGCCATCGCGGTCGCCTG
CGATCCGCCACCCACCCGTTGA

Antitoxin

Protein

• Length: 79 a.a.
• Molecular weight: 8666.52 Da
• Isoelectric Point: 4.5852

>AT36174 WP_163673447.1 NZ_AP022570:c2071981-2071745 [Mycolicibacterium poriferae]
MPRIRVSTTVDSDLLDTARRLRAGSTDAALLDEALSALLARHRSAEVDASYAIYDEHPLHDEDEWGDLASWRRVASTS

Nucleotide

• Length: 237 bp

>AT36174 NZ_AP022570:c2071981-2071745 [Mycolicibacterium poriferae]
ATGCCACGCATACGTGTCAGTACCACCGTCGATTCCGATCTTCTCGACACCGCTCGCCGACTTCGTGCGGGGAGCACCGA
CGCGGCTCTTCTCGACGAAGCCCTTTCCGCGCTGCTTGCGCGCCATCGCAGTGCTGAGGTCGACGCGAGCTACGCCATAT
ATGACGAACATCCACTCCACGACGAAGACGAGTGGGGTGACCTCGCGTCCTGGCGTCGGGTGGCCAGCACGTCGTGA