Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PemK-MazE
Location 2005740..2006284 Replicon chromosome
Accession NZ_AP022570
Organism Mycolicibacterium poriferae strain JCM 12603

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag G6N39_RS09595 Protein ID WP_163673403.1
Coordinates 2005740..2006069 (-) Length 110 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag G6N39_RS09600 Protein ID WP_163673404.1
Coordinates 2006072..2006284 (-) Length 71 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6N39_RS09575 2002151..2003470 - 1320 WP_197746580.1 aminotransferase class III-fold pyridoxal phosphate-dependent enzyme -
G6N39_RS09580 2003492..2004946 + 1455 WP_163673400.1 NAD-dependent succinate-semialdehyde dehydrogenase -
G6N39_RS09585 2005060..2005308 + 249 WP_163673401.1 ribbon-helix-helix protein, CopG family -
G6N39_RS09590 2005302..2005646 + 345 WP_163673402.1 type II toxin-antitoxin system PemK/MazF family toxin -
G6N39_RS09595 2005740..2006069 - 330 WP_163673403.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
G6N39_RS09600 2006072..2006284 - 213 WP_163673404.1 antitoxin MazE family protein Antitoxin
G6N39_RS09605 2006405..2007085 - 681 WP_163673405.1 GntR family transcriptional regulator -
G6N39_RS09610 2007082..2007801 - 720 WP_170311200.1 maleate cis-trans isomerase -
G6N39_RS09615 2007850..2010699 + 2850 WP_163673406.1 FAD-binding oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-107)

Antitoxin

Antitoxin MazE-like

(5-68)


Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 11635.43 Da        Isoelectric Point: 8.7154

>T36173 WP_163673403.1 NZ_AP022570:c2006069-2005740 [Mycolicibacterium poriferae]
VRRGDIFIAAARGAYTGKPRPVVVIQDDRFDGTASVTVVPFTTGDLDAPLLRIAVQPSVTTGLTETSRLMVDKVTTVPRT
SLTQQIGRLTDQDLVGLERALLVFLGLAG

Download         Length: 330 bp

>T36173 NZ_AP022570:c2006069-2005740 [Mycolicibacterium poriferae]
GTGCGGCGAGGTGACATCTTCATCGCCGCAGCGCGCGGCGCCTACACCGGAAAACCACGGCCGGTCGTAGTAATTCAGGA
CGACCGGTTCGACGGCACCGCCTCAGTCACCGTGGTGCCGTTCACCACGGGCGACCTCGATGCGCCCTTGCTTCGCATCG
CGGTACAGCCATCCGTTACCACCGGTCTGACTGAGACCAGCCGCCTGATGGTCGACAAGGTGACGACGGTGCCCCGCACC
AGCCTGACGCAGCAGATCGGCCGCCTGACCGATCAAGACCTGGTCGGACTCGAGCGCGCGCTGCTGGTCTTCCTCGGTTT
AGCGGGCTGA

Antitoxin


Download         Length: 71 a.a.        Molecular weight: 8068.86 Da        Isoelectric Point: 5.0623

>AT36173 WP_163673404.1 NZ_AP022570:c2006284-2006072 [Mycolicibacterium poriferae]
MPPSRERVRRHRERLRQQGLRPIQVWVPDVNAPEFIREAHRQSTLVAASESESDDQAFVDAVSADWDDAS

Download         Length: 213 bp

>AT36173 NZ_AP022570:c2006284-2006072 [Mycolicibacterium poriferae]
ATGCCACCCTCCCGGGAACGCGTTCGCCGGCATCGCGAGCGGTTGCGCCAGCAGGGCCTGCGGCCCATCCAGGTCTGGGT
ACCCGACGTCAACGCTCCAGAATTCATCCGCGAAGCGCACCGCCAGTCGACACTGGTTGCCGCCAGCGAAAGCGAGTCCG
ACGATCAAGCCTTCGTCGACGCCGTCTCCGCTGACTGGGATGACGCGTCGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References