Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Fic(toxin)
Location 1467254..1467840 Replicon chromosome
Accession NZ_AP022570
Organism Mycolicibacterium poriferae strain JCM 12603

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag G6N39_RS06940 Protein ID WP_163673071.1
Coordinates 1467448..1467840 (+) Length 131 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag G6N39_RS06935 Protein ID WP_152515566.1
Coordinates 1467254..1467451 (+) Length 66 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6N39_RS06910 1462522..1463574 - 1053 WP_179967624.1 DNA-binding protein -
G6N39_RS06915 1463699..1465291 - 1593 WP_163673068.1 MFS transporter -
G6N39_RS06920 1465493..1465876 + 384 WP_163673069.1 hypothetical protein -
G6N39_RS06925 1465873..1466445 - 573 WP_163673070.1 Uma2 family endonuclease -
G6N39_RS06930 1466665..1467169 + 505 Protein_1374 hypothetical protein -
G6N39_RS06935 1467254..1467451 + 198 WP_152515566.1 antitoxin Phd Antitoxin
G6N39_RS06940 1467448..1467840 + 393 WP_163673071.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
G6N39_RS06945 1467854..1470385 - 2532 WP_163673072.1 SEC-C domain-containing protein -
G6N39_RS06950 1470527..1472182 + 1656 WP_163673073.1 NERD domain-containing protein -
G6N39_RS06955 1472370..1472756 - 387 WP_163679894.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(19-125)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14008.75 Da        Isoelectric Point: 4.0304

>T36171 WP_163673071.1 NZ_AP022570:1467448-1467840 [Mycolicibacterium poriferae]
VTEYLDREDVLMAGAAAVGIELRVADYGLLDAAVARPQATAFGVDAYPDLFTKAAALLQSLARNHALVDGNKRTAWAAAW
TFLFINGIELPPDFDVDHAEDFMNSLATQGDLELVELARALQDFAADKSP

Download         Length: 393 bp

>T36171 NZ_AP022570:1467448-1467840 [Mycolicibacterium poriferae]
GTGACCGAGTACCTCGATCGGGAAGACGTTCTGATGGCCGGGGCCGCGGCCGTGGGCATCGAGCTGCGTGTCGCCGACTA
CGGATTGCTCGACGCTGCCGTGGCACGGCCGCAGGCGACCGCATTCGGAGTCGACGCCTACCCCGATCTGTTCACCAAGG
CGGCAGCGTTGTTGCAGTCACTCGCCCGCAACCACGCGCTGGTCGACGGAAACAAGCGGACAGCATGGGCCGCGGCGTGG
ACGTTCCTGTTCATCAACGGCATCGAACTCCCGCCCGATTTCGATGTCGATCACGCCGAGGACTTCATGAATTCCCTAGC
CACCCAGGGGGATCTGGAGCTCGTCGAACTCGCCCGGGCACTCCAGGACTTCGCAGCCGACAAATCGCCGTGA

Antitoxin


Download         Length: 66 a.a.        Molecular weight: 7202.17 Da        Isoelectric Point: 11.0635

>AT36171 WP_152515566.1 NZ_AP022570:1467254-1467451 [Mycolicibacterium poriferae]
MPALNVNFTDEEMEQLRTAAASGELSLRAFVHRAALDAASDHKRRVRAAARIVAERSAELNRRLA

Download         Length: 198 bp

>AT36171 NZ_AP022570:1467254-1467451 [Mycolicibacterium poriferae]
ATGCCGGCTTTGAACGTCAATTTCACCGACGAAGAGATGGAGCAGCTACGCACCGCTGCCGCGTCGGGAGAGCTGTCATT
GCGAGCTTTCGTGCACCGAGCTGCGTTGGATGCTGCCAGTGACCACAAACGTCGGGTCCGCGCGGCCGCCCGCATCGTCG
CCGAACGGAGCGCCGAACTCAACCGCCGCCTGGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References