Detailed information of TA system TA036169

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 1336781..1337456
• Replicon: chromosome
• Accession: NZ_AP022570
• Organism: Mycolicibacterium poriferae strain JCM 12603

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: G6N39_RS06415
• Protein ID: WP_163672987.1
• Coordinates: 1337025..1337456 (+)
• Length: 144 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: G6N39_RS06410
• Protein ID: WP_163672986.1
• Coordinates: 1336781..1337038 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G6N39_RS06385	1332469..1333476	+	1008	WP_173011951.1	polyprenyl synthetase family protein	-
G6N39_RS06390	1333569..1334459	+	891	WP_152515467.1	zinc metalloprotease HtpX	-
G6N39_RS06395	1334526..1334993	+	468	WP_163672983.1	hypothetical protein	-
G6N39_RS06400	1335030..1335557	+	528	WP_163672984.1	hypothetical protein	-
G6N39_RS06405	1335631..1336656	-	1026	WP_163672985.1	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase	-
G6N39_RS06410	1336781..1337038	+	258	WP_163672986.1	ribbon-helix-helix domain-containing protein	Antitoxin
G6N39_RS06415	1337025..1337456	+	432	WP_163672987.1	type II toxin-antitoxin system VapC family toxin	Toxin
G6N39_RS06420	1337463..1337954	-	492	WP_152515473.1	YajQ family cyclic di-GMP-binding protein	-
G6N39_RS06430	1338293..1339720	-	1428	WP_163672988.1	serine hydrolase	-
G6N39_RS06435	1339813..1340064	+	252	WP_163672989.1	type II toxin-antitoxin system ParD family antitoxin	-
G6N39_RS06440	1340061..1340354	+	294	WP_163672990.1	type II toxin-antitoxin system RelE/ParE family toxin	-
G6N39_RS06445	1340362..1341405	-	1044	WP_163672991.1	PQQ-dependent sugar dehydrogenase	-
G6N39_RS06450	1341404..1342399	+	996	WP_163679869.1	endonuclease/exonuclease/phosphatase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain toxin (3-142)

Antitoxin

• Ribbon-helix-helix protein, CopG (2-38)

Sequences

Toxin

Protein

• Length: 144 a.a.
• Molecular weight: 16412.39 Da
• Isoelectric Point: 4.8149

>T36169 WP_163672987.1 NZ_AP022570:1337025-1337456 [Mycolicibacterium poriferae]
VRCVDTNVLVYAHRSDLVEHNDYREILEIWANDDEPLGVPDVVLSGFVRIMTNRRVFREPTSPAEAWAAVQALRDAPAVV
ALRPTERHWDLFRQLATDIDARGNDVPDAYLAAYALENNATFYSADRGFARFRCITWRHPLEE

Nucleotide

• Length: 432 bp

>T36169 NZ_AP022570:1337025-1337456 [Mycolicibacterium poriferae]
GTGCGATGCGTTGACACCAACGTCCTCGTCTACGCGCACCGGTCCGATCTCGTCGAGCACAACGACTATCGGGAAATACT
CGAGATCTGGGCCAACGACGACGAACCCCTTGGTGTCCCAGACGTGGTGCTGAGCGGTTTCGTGCGGATCATGACCAACC
GGCGGGTTTTTCGTGAGCCCACCAGCCCCGCAGAGGCGTGGGCGGCTGTGCAGGCGCTACGCGACGCTCCTGCGGTCGTC
GCTTTGCGGCCGACAGAGCGTCACTGGGATTTGTTCCGGCAGCTCGCCACCGACATCGACGCGCGCGGCAACGACGTGCC
GGACGCGTACCTGGCGGCCTACGCCCTGGAGAACAATGCGACGTTCTACAGCGCCGATCGCGGCTTCGCCCGCTTCCGCT
GCATCACCTGGCGGCACCCTCTGGAGGAATGA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 8987.12 Da
• Isoelectric Point: 8.7488

>AT36169 WP_163672986.1 NZ_AP022570:1336781-1337038 [Mycolicibacterium poriferae]
MRTTIRIDDALYREVKERAARSGRTVAAVLEDAVRRGLNPADRGARSLFVVQASGSGGLRPGVDLASNAAVSDVMEEGDS
LGAMR

Nucleotide

• Length: 258 bp

>AT36169 NZ_AP022570:1336781-1337038 [Mycolicibacterium poriferae]
ATGCGCACGACCATCCGCATCGATGACGCGCTGTACCGCGAAGTGAAGGAGCGTGCGGCCCGTTCCGGCCGCACGGTGGC
GGCGGTGCTCGAGGACGCGGTGCGTCGCGGCCTCAACCCGGCCGACCGGGGTGCACGGAGCCTGTTCGTGGTGCAGGCGA
GCGGCAGCGGCGGGTTGCGACCCGGCGTGGACCTTGCCTCGAATGCCGCGGTGTCGGACGTGATGGAGGAAGGGGACAGC
CTCGGTGCGATGCGTTGA