Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pezAT/zeta-ParD
Location 4381651..4382654 Replicon chromosome
Accession NZ_AP022569
Organism Mycobacterium cookii strain JCM 12404

Toxin (Protein)


Gene name pezT Uniprot ID -
Locus tag G6N27_RS20505 Protein ID WP_163779597.1
Coordinates 4381651..4382226 (-) Length 192 a.a.

Antitoxin (Protein)


Gene name pezA Uniprot ID -
Locus tag G6N27_RS20510 Protein ID WP_163779599.1
Coordinates 4382223..4382654 (-) Length 144 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6N27_RS20470 4376903..4377592 - 690 WP_163782096.1 ankyrin repeat domain-containing protein -
G6N27_RS20475 4377747..4378643 + 897 WP_163779585.1 Helicase associated domain protein -
G6N27_RS20480 4378650..4379741 - 1092 WP_163779587.1 metallophosphoesterase -
G6N27_RS20485 4379680..4380219 + 540 WP_163779589.1 nitroreductase family protein -
G6N27_RS20490 4380321..4380566 + 246 WP_163779591.1 type II toxin-antitoxin system VapB family antitoxin -
G6N27_RS20495 4380563..4380958 + 396 WP_163779593.1 type II toxin-antitoxin system VapC family toxin -
G6N27_RS20500 4381135..4381650 + 516 WP_163779595.1 nitroreductase family protein -
G6N27_RS20505 4381651..4382226 - 576 WP_163779597.1 zeta toxin family protein Toxin
G6N27_RS20510 4382223..4382654 - 432 WP_163779599.1 hypothetical protein Antitoxin
G6N27_RS20515 4382851..4383888 + 1038 WP_163779601.1 C40 family peptidase -
G6N27_RS20520 4383885..4384691 - 807 WP_163779603.1 adenylate/guanylate cyclase domain-containing protein -
G6N27_RS20525 4384962..4386314 + 1353 WP_163779605.1 serine hydrolase -
G6N27_RS20530 4386365..4387129 + 765 WP_163779607.1 class I SAM-dependent methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4338838..4386314 47476


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(4-136)

Antitoxin

ParD-like antitoxin of type II bacterial toxin-antitoxin system

(6-106)


Sequences

Toxin        


Download         Length: 192 a.a.        Molecular weight: 20932.08 Da        Isoelectric Point: 7.9446

>T36168 WP_163779597.1 NZ_AP022569:c4382226-4381651 [Mycobacterium cookii]
MKRLDLVVGPNGAGKTTFVELTLAPLLPGSAFVNADEIAKQRWPEDPASHSYQAARVAAETRAKLIGMGASFIAETVFSH
PSKLELIDAAHARDYTVVLHVLLIPEELAVERVRRRVSAGGHDVPENKIRERYQRLWGLVATAIIRCDSATVYDSSRLKG
PLIVAQMNDGFCVGPSAWPLWTPEVLKHNAT

Download         Length: 576 bp

>T36168 NZ_AP022569:c4382226-4381651 [Mycobacterium cookii]
ATGAAGCGGCTCGATCTCGTAGTCGGACCCAACGGAGCCGGCAAGACAACGTTCGTCGAACTCACGCTGGCGCCGCTGTT
GCCTGGCAGCGCCTTCGTCAACGCCGACGAGATTGCCAAACAGCGCTGGCCCGAGGACCCCGCCTCGCATTCGTATCAGG
CCGCGCGGGTGGCAGCAGAAACGAGAGCCAAGCTCATCGGGATGGGCGCGTCGTTCATCGCCGAAACCGTGTTCTCCCAT
CCGTCGAAGCTGGAACTCATCGATGCAGCCCACGCGCGGGACTACACGGTCGTGCTGCATGTTCTGCTGATTCCCGAGGA
GCTGGCGGTCGAGCGGGTCCGGCGCCGAGTCAGTGCCGGTGGACACGATGTGCCCGAGAACAAAATTCGCGAACGCTACC
AACGTCTTTGGGGACTGGTCGCTACTGCGATCATCCGTTGCGATTCGGCGACGGTTTACGACAGCAGCAGGCTCAAAGGA
CCCCTCATCGTCGCTCAGATGAACGACGGCTTTTGCGTCGGCCCGTCGGCTTGGCCGTTGTGGACGCCTGAAGTCTTAAA
GCATAACGCGACCTGA

Antitoxin


Download         Length: 144 a.a.        Molecular weight: 15311.02 Da        Isoelectric Point: 10.4199

>AT36168 WP_163779599.1 NZ_AP022569:c4382654-4382223 [Mycobacterium cookii]
MTNTADRVTRVAADLMDSAATEGARQSRSAKQQLDHWARVGRAVSSQQTAARRRVEAALAGDLELRELSVEEGAVFNAEV
AAAIQESLAGSNYGKLLAERGVTTVALDDNGDIVEHRPDGSSVTLTAKRRPARRRKASATPTR

Download         Length: 432 bp

>AT36168 NZ_AP022569:c4382654-4382223 [Mycobacterium cookii]
ATGACGAACACTGCCGACCGGGTAACTCGAGTTGCGGCCGACCTCATGGACAGCGCCGCGACTGAGGGCGCGCGACAGAG
CCGCTCGGCCAAGCAGCAGCTTGACCACTGGGCGCGGGTGGGGCGCGCGGTATCGAGCCAGCAGACGGCGGCCCGGCGGC
GGGTCGAAGCCGCGCTGGCCGGTGATCTGGAGCTGCGCGAACTCAGCGTCGAAGAGGGCGCGGTGTTCAACGCCGAGGTC
GCCGCGGCCATTCAAGAGAGCCTTGCGGGATCGAATTACGGAAAGCTGCTGGCCGAACGCGGCGTCACCACCGTGGCTCT
CGATGACAACGGTGACATCGTCGAGCACCGGCCTGACGGGTCGTCGGTCACGCTGACCGCGAAACGCCGCCCGGCACGGC
GCAGGAAGGCCAGCGCCACGCCCACCCGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References