Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 4380321..4380958 Replicon chromosome
Accession NZ_AP022569
Organism Mycobacterium cookii strain JCM 12404

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag G6N27_RS20495 Protein ID WP_163779593.1
Coordinates 4380563..4380958 (+) Length 132 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag G6N27_RS20490 Protein ID WP_163779591.1
Coordinates 4380321..4380566 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6N27_RS20465 4375378..4376871 - 1494 WP_163779582.1 ADP-ribosylglycohydrolase family protein -
G6N27_RS20470 4376903..4377592 - 690 WP_163782096.1 ankyrin repeat domain-containing protein -
G6N27_RS20475 4377747..4378643 + 897 WP_163779585.1 Helicase associated domain protein -
G6N27_RS20480 4378650..4379741 - 1092 WP_163779587.1 metallophosphoesterase -
G6N27_RS20485 4379680..4380219 + 540 WP_163779589.1 nitroreductase family protein -
G6N27_RS20490 4380321..4380566 + 246 WP_163779591.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
G6N27_RS20495 4380563..4380958 + 396 WP_163779593.1 type II toxin-antitoxin system VapC family toxin Toxin
G6N27_RS20500 4381135..4381650 + 516 WP_163779595.1 nitroreductase family protein -
G6N27_RS20505 4381651..4382226 - 576 WP_163779597.1 zeta toxin family protein -
G6N27_RS20510 4382223..4382654 - 432 WP_163779599.1 hypothetical protein -
G6N27_RS20515 4382851..4383888 + 1038 WP_163779601.1 C40 family peptidase -
G6N27_RS20520 4383885..4384691 - 807 WP_163779603.1 adenylate/guanylate cyclase domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 4338838..4386314 47476


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(1-124)

Antitoxin

Antitoxin VapB-like

(1-80)


Sequences

Toxin        


Download         Length: 132 a.a.        Molecular weight: 14096.93 Da        Isoelectric Point: 4.6138

>T36167 WP_163779593.1 NZ_AP022569:4380563-4380958 [Mycobacterium cookii]
MIVDTSAVIAILKGEDDAALYAQAIAHAGARRLSAASYLECGIVLDSQRDPIISRALDELIQEAEFVIEPVTEHQAHLAR
RAYADFGKGRHPAGLNFGDCLTYALALDLRESLLWKGEDFGRTGVESALGG

Download         Length: 396 bp

>T36167 NZ_AP022569:4380563-4380958 [Mycobacterium cookii]
ATGATCGTGGACACGTCGGCAGTGATCGCGATCCTCAAAGGCGAAGACGACGCCGCGCTCTACGCGCAGGCCATCGCGCA
CGCCGGCGCCCGAAGGCTCTCTGCGGCAAGCTATCTCGAATGTGGGATCGTCCTCGACTCTCAGCGAGACCCGATAATCA
GCAGAGCTCTCGACGAGCTTATCCAGGAAGCCGAGTTCGTGATCGAGCCGGTGACCGAGCACCAGGCCCACCTGGCCCGT
CGGGCCTACGCAGATTTTGGCAAAGGCAGGCACCCAGCGGGGTTGAACTTCGGTGATTGCCTCACTTATGCCCTCGCGCT
CGATCTACGGGAGTCACTGTTGTGGAAGGGCGAGGATTTCGGTCGCACGGGCGTCGAATCCGCGCTCGGCGGATGA

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8692.97 Da        Isoelectric Point: 7.3187

>AT36167 WP_163779591.1 NZ_AP022569:4380321-4380566 [Mycobacterium cookii]
MALNIKDVSVHEAVKQIAKITGESQAQAVATAVNERLARLQGDDLASRLLAIGHKTASRMSPETKMLDHGALLYDERGLP
A

Download         Length: 246 bp

>AT36167 NZ_AP022569:4380321-4380566 [Mycobacterium cookii]
ATGGCGTTGAACATCAAAGATGTGTCTGTGCACGAAGCGGTGAAGCAGATCGCGAAAATCACCGGCGAGTCCCAGGCGCA
GGCGGTAGCGACGGCGGTGAATGAGCGTTTGGCCCGACTGCAGGGCGACGATCTCGCATCCCGGCTTCTCGCCATCGGCC
ACAAGACCGCCAGCCGGATGAGCCCCGAGACCAAAATGCTGGACCACGGTGCGCTGCTGTACGACGAGCGAGGGCTGCCA
GCATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References