Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/Polyketide_cyc2(toxin)
Location 3508440..3509103 Replicon chromosome
Accession NZ_AP022568
Organism Mycobacterium simiae strain JCM 12377

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID A0A1X0YAV4
Locus tag G6N33_RS16510 Protein ID WP_044508282.1
Coordinates 3508630..3509103 (+) Length 158 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID A0A1X0YB24
Locus tag G6N33_RS16505 Protein ID WP_044508284.1
Coordinates 3508440..3508625 (+) Length 62 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6N33_RS16490 3503725..3504315 - 591 WP_044508288.1 G/U mismatch-specific DNA glycosylase -
G6N33_RS16495 3504360..3505952 + 1593 WP_044508287.1 serine hydrolase -
G6N33_RS16500 3505949..3508354 + 2406 WP_044508286.1 HAD-IC family P-type ATPase -
G6N33_RS16505 3508440..3508625 + 186 WP_044508284.1 antitoxin Antitoxin
G6N33_RS16510 3508630..3509103 + 474 WP_044508282.1 SRPBCC family protein Toxin
G6N33_RS16515 3509180..3509614 + 435 WP_044508280.1 membrane protein -
G6N33_RS16520 3509618..3510109 - 492 WP_044508277.1 VOC family protein -
G6N33_RS16525 3510141..3511667 - 1527 WP_044508275.1 carotenoid oxygenase family protein -
G6N33_RS16530 3511671..3512906 - 1236 WP_044508274.1 acetyl-CoA acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Polyketide cyclase/dehydrase

(1-142)

Antitoxin

Antitoxin Rv0909/MT0933

(4-52)


Sequences

Toxin        


Download         Length: 158 a.a.        Molecular weight: 16982.67 Da        Isoelectric Point: 9.5157

>T36162 WP_044508282.1 NZ_AP022568:3508630-3509103 [Mycobacterium simiae]
MAKLSGSIDVPLSPEEAWKHASDLSRYKDWLSIHRVWRSKLPDDLQKGTVIESIVEVKGMLNRIKWTIVHYKPPEAMTLN
GDGVGGVRVKLLAKVKPKGDGSVVSFDVHLGGPALFGPIGMIVAAALRSDIDESLERFVTVFTGADPGMNGARGLGH

Download         Length: 474 bp

>T36162 NZ_AP022568:3508630-3509103 [Mycobacterium simiae]
ATGGCGAAACTCTCCGGATCCATCGACGTCCCCCTGTCACCAGAGGAGGCGTGGAAGCACGCCTCCGACCTGTCCCGCTA
CAAGGATTGGCTGAGCATTCACCGGGTCTGGCGCAGCAAGCTGCCCGACGACCTGCAAAAAGGCACGGTGATCGAATCGA
TCGTCGAGGTCAAAGGCATGCTCAACCGGATCAAGTGGACGATTGTGCACTACAAGCCGCCGGAGGCGATGACCCTCAAC
GGCGACGGTGTCGGTGGTGTCAGGGTCAAGCTGCTGGCGAAGGTCAAGCCAAAAGGCGACGGCTCGGTGGTCAGCTTCGA
CGTGCATCTCGGCGGCCCGGCGCTGTTCGGGCCTATCGGCATGATCGTCGCCGCCGCGCTGCGCAGTGACATCGACGAGT
CGCTGGAAAGATTCGTCACCGTGTTCACCGGCGCCGACCCCGGCATGAACGGAGCGCGCGGCCTCGGCCACTGA

Antitoxin


Download         Length: 62 a.a.        Molecular weight: 6688.31 Da        Isoelectric Point: 4.7596

>AT36162 WP_044508284.1 NZ_AP022568:3508440-3508625 [Mycobacterium simiae]
MGFLDKAKDLLAQHADEVETAIDKAGEFVDDKTQGKYSDTIHKVQEEAKKAADSAKGDQHN

Download         Length: 186 bp

>AT36162 NZ_AP022568:3508440-3508625 [Mycobacterium simiae]
ATGGGATTCCTGGACAAGGCGAAAGACCTGTTGGCGCAGCATGCCGACGAGGTCGAGACAGCGATCGACAAGGCCGGCGA
GTTCGTCGACGACAAGACGCAGGGCAAATATTCCGACACCATCCACAAGGTGCAGGAGGAGGCCAAGAAGGCGGCCGACT
CCGCCAAGGGCGACCAGCACAACTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1X0YAV4

Antitoxin

Source ID Structure
AlphaFold DB A0A1X0YB24

References