Detailed information of TA system TA036160

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/RHH(antitoxin)
• Location: 2701998..2702542
• Replicon: chromosome
• Accession: NZ_AP022567
• Organism: Mycolicibacterium mageritense strain JCM 12375

Toxin (Protein)

• Gene name: parE
• Uniprot ID: X5KJM4
• Locus tag: G6N67_RS12700
• Protein ID: WP_036430693.1
• Coordinates: 2702246..2702542 (+)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: X5KR67
• Locus tag: G6N67_RS12695
• Protein ID: WP_036430692.1
• Coordinates: 2701998..2702249 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G6N67_RS12675	2697186..2697878	-	693	WP_036430686.1	class I SAM-dependent methyltransferase	-
G6N67_RS12680	2697969..2698745	+	777	WP_036430688.1	helix-turn-helix transcriptional regulator	-
G6N67_RS12685	2698756..2699784	-	1029	WP_036435013.1	MaoC family dehydratase N-terminal domain-containing protein	-
G6N67_RS12690	2699880..2701745	-	1866	WP_036430690.1	hypothetical protein	-
G6N67_RS12695	2701998..2702249	+	252	WP_036430692.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
G6N67_RS12700	2702246..2702542	+	297	WP_036430693.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
G6N67_RS12705	2702553..2703548	-	996	WP_063835106.1	glycoside hydrolase family 6 protein	-
G6N67_RS12710	2703612..2704394	-	783	WP_036430695.1	hypothetical protein	-
G6N67_RS12715	2704417..2704968	-	552	WP_110798377.1	ATP/GTP-binding protein	-
G6N67_RS12720	2704982..2705359	-	378	WP_036430699.1	DUF742 domain-containing protein	-
G6N67_RS12725	2705359..2705727	-	369	WP_036435016.1	roadblock/LC7 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-92)

Antitoxin

• Antitoxin ParD (2-78)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11446.99 Da
• Isoelectric Point: 6.2206

>T36160 WP_036430693.1 NZ_AP022567:2702246-2702542 [Mycolicibacterium mageritense]
VSRYVLSPAARADLESIWDYTCERWDIKQAEEYVREIQLAVERIVANPMIGRACDDVRPGYRKHAVGSHTLYYRIGGGDM
VDVVRILHQRMDVDRYFD

Nucleotide

• Length: 297 bp

>T36160 NZ_AP022567:2702246-2702542 [Mycolicibacterium mageritense]
GTGAGTCGTTATGTCCTTTCACCCGCTGCGCGGGCGGACCTGGAATCAATCTGGGATTACACGTGTGAACGATGGGACAT
CAAGCAGGCGGAGGAATACGTCCGTGAAATCCAGCTCGCGGTCGAACGTATCGTCGCGAATCCCATGATCGGACGGGCGT
GCGACGACGTCCGCCCCGGATACCGCAAGCACGCTGTCGGATCCCATACGCTGTACTACCGGATCGGCGGTGGCGACATG
GTTGACGTTGTGCGCATCCTCCACCAACGAATGGACGTGGACCGGTACTTCGACTGA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9520.52 Da
• Isoelectric Point: 5.9008

>AT36160 WP_036430692.1 NZ_AP022567:2701998-2702249 [Mycolicibacterium mageritense]
VGKNTSFSLDEHFSSFIEEEVASGRYRSASDVVRTALRLLEDRETRLRALRRELIAGERSGESTPFDFDQFIAGKRTEEP
RAR

Nucleotide

• Length: 252 bp

>AT36160 NZ_AP022567:2701998-2702249 [Mycolicibacterium mageritense]
GTGGGTAAGAACACGTCATTCAGCCTCGACGAGCATTTCAGCTCTTTCATCGAGGAGGAGGTCGCATCGGGCCGGTACCG
CTCGGCCAGCGATGTCGTTCGTACAGCACTGCGACTGCTGGAGGACCGTGAGACCCGCCTGCGGGCATTGCGTCGGGAAC
TCATCGCCGGTGAACGAAGCGGCGAATCAACACCGTTCGACTTCGATCAATTCATCGCGGGCAAGCGAACTGAAGAACCC
CGCGCGCGGTGA

Structures

Toxin

• AlphaFold DB: X5KJM4

Antitoxin

• AlphaFold DB: X5KR67