Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Fic(toxin)
Location 146415..147013 Replicon plasmid pJCM12272
Accession NZ_AP022566
Organism Mycolicibacterium alvei strain JCM 12272

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag G6N44_RS28260 Protein ID WP_163670605.1
Coordinates 146415..146813 (-) Length 133 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag G6N44_RS28265 Protein ID WP_163670607.1
Coordinates 146810..147013 (-) Length 68 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6N44_RS28235 141755..142195 - 441 WP_163670598.1 hypothetical protein -
G6N44_RS28240 142182..142481 - 300 WP_163670600.1 hypothetical protein -
G6N44_RS28245 142680..143036 - 357 WP_163670602.1 hypothetical protein -
G6N44_RS28250 143447..144949 - 1503 WP_163670603.1 IMP dehydrogenase -
G6N44_RS28255 145183..146331 - 1149 WP_163670604.1 hypothetical protein -
G6N44_RS28260 146415..146813 - 399 WP_163670605.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
G6N44_RS28265 146810..147013 - 204 WP_163670607.1 antitoxin Phd Antitoxin
G6N44_RS28270 147074..147511 - 438 WP_163670609.1 hypothetical protein -
G6N44_RS28275 147514..147855 - 342 WP_163670611.1 hypothetical protein -
G6N44_RS28280 147973..148824 - 852 WP_163670613.1 zeta toxin family protein -
G6N44_RS28285 148828..149292 - 465 WP_163670615.1 winged helix-turn-helix domain-containing protein -
G6N44_RS28290 149806..150750 + 945 WP_163670617.1 hypothetical protein -
G6N44_RS28295 150830..151666 - 837 WP_163670619.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..304163 304163


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(27-83)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 13778.46 Da        Isoelectric Point: 3.8862

>T36158 WP_163670605.1 NZ_AP022566:c146813-146415 [Mycolicibacterium alvei]
VIRYLDRDDVLVAGTAALGEVPAVTDYGLLESALARPSATVFGLDAYPDVLSKAAALLQSLARNHAFVDGNVTTAWAATW
IFLTINGVELAAEYDVDAAECLVLNVATGVETSVESIAESLHEFADGGGVRP

Download         Length: 399 bp

>T36158 NZ_AP022566:c146813-146415 [Mycolicibacterium alvei]
GTGATCCGCTATCTCGATCGCGACGATGTCCTTGTCGCGGGCACGGCCGCCCTCGGGGAAGTGCCTGCAGTTACCGACTA
CGGACTGCTGGAGTCAGCGCTCGCTCGGCCGAGCGCAACAGTTTTCGGTCTCGACGCCTATCCGGATGTACTGAGCAAGG
CTGCCGCGCTCCTGCAGTCCCTGGCCCGCAACCATGCCTTCGTTGACGGCAATGTAACAACCGCGTGGGCTGCAACGTGG
ATCTTCCTGACTATCAACGGTGTCGAGTTGGCCGCCGAATACGACGTGGACGCAGCGGAATGCCTGGTCCTCAATGTCGC
CACCGGAGTAGAGACTTCGGTCGAATCCATCGCCGAGTCGCTGCACGAGTTTGCCGATGGTGGCGGTGTCCGGCCATGA

Antitoxin


Download         Length: 68 a.a.        Molecular weight: 7444.35 Da        Isoelectric Point: 7.2037

>AT36158 WP_163670607.1 NZ_AP022566:c147013-146810 [Mycolicibacterium alvei]
MAALNVPFDDAELASIRTAAQEADQSLKDFVHDAAMQRADRHKQQVAAAAQLVAQRSAELNRRLREK

Download         Length: 204 bp

>AT36158 NZ_AP022566:c147013-146810 [Mycolicibacterium alvei]
ATGGCCGCTTTGAACGTCCCGTTCGACGACGCCGAGCTCGCTAGCATCCGGACAGCCGCCCAGGAAGCTGACCAGAGCTT
GAAGGATTTCGTGCACGACGCCGCCATGCAGCGCGCGGATCGCCACAAGCAACAGGTGGCGGCAGCCGCGCAGCTAGTAG
CTCAGCGATCTGCCGAGCTGAACCGGCGGTTGCGTGAAAAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References