Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/Polyketide_cyc2(toxin)
Location 4705892..4706521 Replicon chromosome
Accession NZ_AP022565
Organism Mycolicibacterium alvei strain JCM 12272

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID -
Locus tag G6N44_RS22445 Protein ID WP_163667835.1
Coordinates 4706075..4706521 (+) Length 149 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID -
Locus tag G6N44_RS22440 Protein ID WP_163667834.1
Coordinates 4705892..4706071 (+) Length 60 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6N44_RS22425 4701466..4702200 + 735 WP_163667828.1 enoyl-CoA hydratase -
G6N44_RS22430 4702202..4703317 + 1116 WP_163667830.1 MBL fold metallo-hydrolase -
G6N44_RS22435 4703384..4705867 + 2484 WP_163667832.1 cation-translocating P-type ATPase -
G6N44_RS22440 4705892..4706071 + 180 WP_163667834.1 antitoxin Antitoxin
G6N44_RS22445 4706075..4706521 + 447 WP_163667835.1 SRPBCC family protein Toxin
G6N44_RS22450 4706541..4708010 - 1470 WP_163667837.1 long-chain fatty acid--CoA ligase -
G6N44_RS22455 4708007..4708792 - 786 WP_163667840.1 SDR family oxidoreductase -
G6N44_RS22460 4708795..4710381 - 1587 WP_163670256.1 AMP-binding protein -
G6N44_RS22465 4710400..4711137 - 738 WP_163667842.1 GntR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Polyketide cyclase/dehydrase

(1-145)

Antitoxin

Antitoxin Rv0909/MT0933

(4-52)


Sequences

Toxin        


Download         Length: 149 a.a.        Molecular weight: 15916.45 Da        Isoelectric Point: 9.9528

>T36157 WP_163667835.1 NZ_AP022565:4706075-4706521 [Mycolicibacterium alvei]
MAKLSVSVDVPLPPEKAWEHASDLSRYDDWLSIHRAWRSKLPETLEKGSVLDSIVEVKGMLNRVKWTLVSYKPPHSLTLN
GDGRGGVKVKLIGKITPASVDGGEGAKVSFDVHLGGPALFGPIGMVVAAALKGDIQQSLNKFKALYAS

Download         Length: 447 bp

>T36157 NZ_AP022565:4706075-4706521 [Mycolicibacterium alvei]
ATGGCTAAGTTATCTGTCTCCGTCGATGTCCCGTTGCCGCCGGAGAAGGCGTGGGAGCACGCCTCTGATCTGTCCCGTTA
CGACGACTGGCTCAGCATTCACCGGGCCTGGCGGTCGAAGTTGCCCGAGACCCTCGAGAAGGGCTCGGTCCTCGATTCGA
TCGTCGAAGTCAAGGGCATGCTGAACCGGGTGAAGTGGACGCTGGTGAGCTACAAACCGCCGCACTCGCTGACCCTCAAC
GGCGATGGCCGTGGCGGGGTGAAAGTCAAGCTGATCGGAAAGATCACGCCTGCGTCGGTCGATGGCGGTGAAGGCGCGAA
AGTGTCCTTCGACGTGCACCTCGGCGGGCCCGCCCTGTTCGGGCCGATCGGCATGGTGGTCGCCGCCGCGCTCAAGGGCG
ATATTCAGCAGTCGCTCAACAAGTTCAAGGCGCTCTACGCGTCGTAA

Antitoxin


Download         Length: 60 a.a.        Molecular weight: 6391.08 Da        Isoelectric Point: 4.3867

>AT36157 WP_163667834.1 NZ_AP022565:4705892-4706071 [Mycolicibacterium alvei]
MGFLDKAKDLLSENAEKVEQAIDKAGDVIDEKTQGKFSGAVDKAQEAAKNAINKEEPQQ

Download         Length: 180 bp

>AT36157 NZ_AP022565:4705892-4706071 [Mycolicibacterium alvei]
ATGGGATTCCTGGACAAGGCTAAAGACCTCCTGTCGGAGAACGCCGAGAAGGTGGAGCAGGCCATCGACAAGGCCGGCGA
CGTCATCGACGAGAAGACGCAGGGCAAGTTCTCCGGTGCGGTGGACAAGGCGCAGGAGGCGGCCAAGAACGCCATCAACA
AGGAAGAACCGCAGCAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References