Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 3616679..3617460 Replicon chromosome
Accession NZ_AP022565
Organism Mycolicibacterium alvei strain JCM 12272

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag G6N44_RS17225 Protein ID WP_163665985.1
Coordinates 3616679..3617185 (-) Length 169 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID -
Locus tag G6N44_RS17230 Protein ID WP_163670075.1
Coordinates 3617182..3617460 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6N44_RS17200 3611976..3612749 + 774 WP_163670073.1 4,5-DOPA dioxygenase extradiol -
G6N44_RS17205 3612849..3613715 + 867 WP_163665980.1 glucose-1-phosphate thymidylyltransferase RfbA -
G6N44_RS17210 3613799..3615622 + 1824 WP_163665981.1 WXG100 family type VII secretion target -
G6N44_RS17215 3615687..3616136 + 450 WP_163665982.1 hypothetical protein -
G6N44_RS17220 3616140..3616451 - 312 WP_163665983.1 hypothetical protein -
G6N44_RS17225 3616679..3617185 - 507 WP_163665985.1 GNAT family N-acetyltransferase Toxin
G6N44_RS17230 3617182..3617460 - 279 WP_163670075.1 DUF1778 domain-containing protein Antitoxin
G6N44_RS17240 3618192..3619637 + 1446 WP_163665986.1 DUF3662 domain-containing protein -
G6N44_RS17245 3619770..3620237 + 468 WP_029110475.1 FHA domain-containing protein -
G6N44_RS17250 3620269..3621774 + 1506 WP_163665987.1 protein phosphatase 2C domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(43-145)

Antitoxin

Vibrio phage ICP1, Orf50

(10-85)


Sequences

Toxin        


Download         Length: 169 a.a.        Molecular weight: 18316.09 Da        Isoelectric Point: 9.1081

>T36156 WP_163665985.1 NZ_AP022565:c3617185-3616679 [Mycolicibacterium alvei]
VSGYSAPRPISAHDVVVGFDSGEPSLDEYLRRRALANHVEGASRCFVTCRDGRVVGFYALAPAAVERAGTPGRVRRNMPD
PVPVILLSRLAIDHKEQGKGLGAQLLRDAITRAVVAAEIIGVRALLVHALHEQARTFYAHFDFEPSPTDPLHLLLLIKDA
RALLSPQR

Download         Length: 507 bp

>T36156 NZ_AP022565:c3617185-3616679 [Mycolicibacterium alvei]
GTGAGCGGCTACAGCGCGCCGCGGCCGATCAGCGCGCACGATGTGGTCGTCGGCTTCGACAGTGGCGAGCCCAGCCTGGA
TGAATACCTGCGACGGCGCGCCCTGGCCAACCACGTCGAAGGTGCCTCCAGGTGCTTCGTGACCTGCCGGGACGGCCGCG
TCGTCGGGTTCTACGCGCTGGCCCCGGCGGCGGTGGAGCGCGCCGGTACACCAGGGCGGGTGCGGCGCAACATGCCCGAT
CCGGTGCCGGTGATCCTGTTGTCGCGGCTGGCGATCGACCACAAGGAACAGGGCAAGGGCTTGGGCGCGCAGCTGCTTCG
GGACGCGATCACCCGCGCGGTGGTCGCCGCCGAGATCATCGGTGTGCGGGCACTGCTGGTGCACGCTCTGCATGAGCAGG
CCCGAACGTTCTACGCGCACTTCGACTTCGAGCCGTCACCCACGGACCCACTGCACCTGCTGCTGTTGATCAAAGACGCC
CGTGCCCTGCTCAGCCCGCAGAGGTGA

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10316.85 Da        Isoelectric Point: 6.4662

>AT36156 WP_163670075.1 NZ_AP022565:c3617460-3617182 [Mycolicibacterium alvei]
MVGMATKTKRFAVRLTAEQDALIRRAAEVEGTDLTNFTVTATLAHARDVLADRRLFMLDGPAWSEFVSVLDRPVSHKPQL
EQLFAKPSIFDE

Download         Length: 279 bp

>AT36156 NZ_AP022565:c3617460-3617182 [Mycolicibacterium alvei]
ATGGTTGGCATGGCGACGAAGACGAAGCGTTTCGCGGTGCGCCTGACCGCTGAGCAGGACGCGCTGATTCGTCGTGCCGC
CGAAGTGGAGGGGACCGACCTGACCAACTTCACCGTGACCGCGACGCTGGCTCATGCCCGCGATGTGCTGGCCGATCGCC
GGCTGTTCATGCTCGACGGGCCGGCCTGGTCGGAGTTCGTCTCGGTGCTGGACCGGCCGGTGTCGCATAAGCCGCAGCTG
GAGCAGTTGTTCGCGAAGCCCTCGATCTTCGACGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References