Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Fic(toxin)
Location 2570104..2570684 Replicon chromosome
Accession NZ_AP022565
Organism Mycolicibacterium alvei strain JCM 12272

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag G6N44_RS12430 Protein ID WP_163664358.1
Coordinates 2570104..2570490 (-) Length 129 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag G6N44_RS12435 Protein ID WP_163664361.1
Coordinates 2570487..2570684 (-) Length 66 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6N44_RS12415 2566850..2567248 - 399 WP_163664352.1 hypothetical protein -
G6N44_RS12420 2567293..2567643 - 351 WP_163664354.1 hypothetical protein -
G6N44_RS12425 2567640..2570045 - 2406 WP_163664356.1 AAA family ATPase -
G6N44_RS12430 2570104..2570490 - 387 WP_163664358.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
G6N44_RS12435 2570487..2570684 - 198 WP_163664361.1 antitoxin Phd Antitoxin
G6N44_RS12440 2570767..2571363 - 597 WP_163664363.1 DUF2510 domain-containing protein -
G6N44_RS12445 2571445..2572092 + 648 Protein_2469 metallophosphatase -
G6N44_RS12450 2572071..2573036 - 966 WP_163664365.1 mechanosensitive ion channel family protein -
G6N44_RS12455 2573130..2573789 - 660 WP_163664367.1 NUDIX domain-containing protein -
G6N44_RS12460 2573858..2575270 + 1413 WP_163664368.1 ADP-ribosylglycohydrolase family protein -
G6N44_RS12465 2575279..2575458 - 180 WP_163669870.1 alkylphosphonate transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Death on curing protein

(17-119)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 13817.55 Da        Isoelectric Point: 4.0539

>T36155 WP_163664358.1 NZ_AP022565:c2570490-2570104 [Mycolicibacterium alvei]
VIEYLDRDDVLTAGSIAFGGELQVRDYGLLDAAVARPQATVFGVDAYPQVWEKAAALLQSLARNHALIDGNKRTAWASAW
TFLHINGIELAPDFDIDRAEILMNEVATQDGELGEIVAALLSFSVAST

Download         Length: 387 bp

>T36155 NZ_AP022565:c2570490-2570104 [Mycolicibacterium alvei]
GTGATCGAGTATCTCGACCGCGATGACGTACTGACCGCGGGGTCAATCGCGTTCGGCGGTGAACTGCAGGTGCGTGACTA
TGGCCTGCTCGACGCGGCTGTCGCCCGACCTCAGGCGACGGTCTTCGGGGTGGACGCCTACCCCCAAGTTTGGGAGAAGG
CCGCGGCACTTCTGCAATCGCTTGCCCGTAATCACGCCCTGATCGACGGAAACAAGCGGACCGCCTGGGCATCGGCGTGG
ACGTTCTTGCACATCAACGGGATTGAACTCGCACCCGATTTCGACATCGATAGGGCCGAGATTCTGATGAACGAGGTGGC
GACCCAGGATGGTGAGCTGGGTGAGATCGTCGCTGCACTGTTGAGTTTCAGCGTCGCCAGCACGTGA

Antitoxin


Download         Length: 66 a.a.        Molecular weight: 7289.34 Da        Isoelectric Point: 10.4473

>AT36155 WP_163664361.1 NZ_AP022565:c2570684-2570487 [Mycolicibacterium alvei]
MPSLNLDFDDAEMEQIRAAARADDLSLKKFAHAAVIERASMHKRRVAEAARVVAQRSAELNRRLA

Download         Length: 198 bp

>AT36155 NZ_AP022565:c2570684-2570487 [Mycolicibacterium alvei]
ATGCCTTCATTGAACCTGGACTTCGACGACGCCGAAATGGAGCAGATTCGGGCCGCGGCCCGAGCCGACGACCTGTCGTT
GAAGAAGTTCGCGCACGCGGCCGTCATTGAGCGCGCCAGCATGCACAAGCGCAGGGTGGCCGAGGCGGCGCGGGTCGTGG
CCCAGCGTTCGGCCGAACTCAACCGACGTTTGGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References