Detailed information of TA system TA036151

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PhRel-ATphRel/-
• Location: 2699327..2700419
• Replicon: chromosome
• Accession: NZ_AP022563
• Organism: Mycolicibacterium duvalii strain JCM 6396

Toxin (Protein)

• Gene name: phRel
• Uniprot ID: -
• Locus tag: G6N31_RS12675
• Protein ID: WP_098002877.1
• Coordinates: 2699327..2700199 (+)
• Length: 291 a.a.

Antitoxin (Protein)

• Gene name: ATphRel
• Uniprot ID: -
• Locus tag: G6N31_RS12680
• Protein ID: WP_098002878.1
• Coordinates: 2700201..2700419 (+)
• Length: 73 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G6N31_RS12660	2694584..2696812	-	2229	WP_098002874.1	maltose alpha-D-glucosyltransferase	-
G6N31_RS12665	2696933..2697628	-	696	WP_098002875.1	proteasome protein	-
G6N31_RS12670	2697738..2698631	+	894	WP_098002876.1	NYN domain-containing protein	-
G6N31_RS12675	2699327..2700199	+	873	WP_098002877.1	hypothetical protein	Toxin
G6N31_RS12680	2700201..2700419	+	219	WP_098002878.1	hypothetical protein	Antitoxin
G6N31_RS12685	2700688..2701269	-	582	WP_098002879.1	recombinase family protein	-
G6N31_RS12690	2701506..2702813	+	1308	WP_098002880.1	ATP-binding protein	-
G6N31_RS12695	2702900..2703289	+	390	WP_133117672.1	hypothetical protein	-
G6N31_RS12700	2703872..2704717	-	846	WP_098002882.1	IS21-like element helper ATPase IstB	-
G6N31_RS12705	2704868..2705257	-	390	WP_006246584.1	heavy metal-responsive transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• RelA/SpoT (48-168)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 291 a.a.
• Molecular weight: 32616.98 Da
• Isoelectric Point: 4.8085

>T36151 WP_098002877.1 NZ_AP022563:2699327-2700199 [Mycolicibacterium duvalii]
MDLEQRPSWSKGDLRRLGEALVIDRAATPDDCPSYGEVMLWHNELATEAAIRIATELWAATPPNQLSITARAKTVDTLVQ
KLQRQTTLKLGQVQDLAGVRVDADMVLTHQTELAEHIAEHFGAARSRIKDMRETPHSGYRAVHVWLALPAGRVEVQIRTL
AQSEWANAYEDFAELLGRGIRYGERHENADVRLVVDKMHRVSEIIALREKVIDAAWEAERAIEELAAEAALDPMDSLVNE
NGLNTAQVVGLGRAQLAELSETLLKVRSQIELFVQILRELRRDLQEEEEV

Nucleotide

• Length: 873 bp

>T36151 NZ_AP022563:2699327-2700199 [Mycolicibacterium duvalii]
ATGGATCTTGAACAAAGACCCAGTTGGTCGAAGGGTGATCTGCGCCGCCTCGGGGAAGCCCTAGTCATCGACAGAGCCGC
GACCCCGGACGACTGCCCCTCATATGGCGAGGTGATGCTCTGGCACAACGAACTCGCGACTGAGGCCGCGATAAGAATCG
CGACCGAGCTGTGGGCCGCGACGCCGCCGAACCAGCTGTCGATAACTGCGCGGGCAAAGACGGTCGACACGCTCGTGCAA
AAGTTGCAGCGTCAGACGACCTTAAAACTCGGTCAGGTGCAAGACCTCGCCGGTGTGCGCGTCGACGCCGACATGGTCCT
CACACATCAAACGGAACTCGCGGAACATATCGCCGAACACTTCGGCGCCGCCCGATCAAGAATCAAAGATATGCGCGAGA
CTCCACACAGCGGATACAGAGCAGTTCATGTTTGGCTCGCCCTACCCGCTGGTCGTGTCGAGGTGCAGATCAGGACCCTC
GCTCAAAGTGAGTGGGCGAACGCCTACGAGGACTTCGCCGAGCTGTTGGGCCGCGGCATCCGCTACGGCGAAAGACACGA
GAACGCTGACGTCCGCTTGGTTGTCGATAAGATGCACAGGGTTTCCGAGATCATTGCGCTGCGTGAAAAGGTTATCGACG
CAGCGTGGGAAGCAGAGCGCGCCATCGAAGAGTTGGCTGCTGAAGCGGCGTTGGACCCGATGGACAGCCTTGTCAATGAG
AACGGCTTGAACACTGCCCAGGTAGTTGGGCTAGGGCGTGCGCAGCTCGCGGAACTCTCAGAAACACTTCTCAAAGTGAG
GAGCCAGATAGAGCTTTTCGTTCAGATTCTCCGCGAACTGCGCCGTGACTTACAAGAAGAGGAAGAGGTCTGA

Antitoxin

Protein

• Length: 73 a.a.
• Molecular weight: 8515.57 Da
• Isoelectric Point: 6.4674

>AT36151 WP_098002878.1 NZ_AP022563:2700201-2700419 [Mycolicibacterium duvalii]
MRGFVIQFNRRTGNRRVTEFATPHEAMEYRLQMDAERVDEDIEIVALISESLETVRRTHSRYFTGQELPASR

Nucleotide

• Length: 219 bp

>AT36151 NZ_AP022563:2700201-2700419 [Mycolicibacterium duvalii]
ATGCGAGGCTTCGTGATCCAATTCAATCGCCGCACAGGCAACCGCCGTGTCACCGAGTTCGCCACCCCTCACGAGGCGAT
GGAGTACAGGCTGCAGATGGACGCTGAGCGGGTCGACGAGGACATCGAGATCGTGGCCCTGATCAGCGAGTCACTTGAGA
CTGTCCGGCGCACGCATTCGCGCTATTTCACCGGCCAGGAACTCCCTGCGAGCCGCTAG