Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PemK-MazE
Location 1236029..1236564 Replicon chromosome
Accession NZ_AP022563
Organism Mycolicibacterium duvalii strain JCM 6396

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag G6N31_RS05680 Protein ID WP_098002640.1
Coordinates 1236029..1236361 (-) Length 111 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag G6N31_RS05685 Protein ID WP_098002641.1
Coordinates 1236358..1236564 (-) Length 69 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6N31_RS05665 1232575..1233024 + 450 WP_098002637.1 VOC family protein -
G6N31_RS05670 1233021..1233752 + 732 WP_098002638.1 SDR family oxidoreductase -
G6N31_RS05675 1233749..1235401 + 1653 WP_098002639.1 amidohydrolase family protein -
G6N31_RS05680 1236029..1236361 - 333 WP_098002640.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
G6N31_RS05685 1236358..1236564 - 207 WP_098002641.1 DUF3018 family protein Antitoxin
G6N31_RS05690 1237272..1237883 + 612 WP_098002699.1 FKBP-type peptidyl-prolyl cis-trans isomerase -
G6N31_RS05695 1237928..1239334 - 1407 WP_098002643.1 wax ester/triacylglycerol synthase family O-acyltransferase -
G6N31_RS05700 1239443..1241128 + 1686 WP_163722053.1 GMC family oxidoreductase N-terminal domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1211170..1237178 26008


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-105)

Antitoxin

Antitoxin MazE-like

(4-66)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 11969.85 Da        Isoelectric Point: 10.1854

>T36149 WP_098002640.1 NZ_AP022563:c1236361-1236029 [Mycolicibacterium duvalii]
VNRGEIWTVAGGVYAGKPRPAVIVQDDLFDATRSVTVAPMTSALLDAPLMRIRIAGRDGRLSGLDHDSDVMIDKLTTVRR
SNVHARVGRLTAEQVVEVERAMMAFLGLAR

Download         Length: 333 bp

>T36149 NZ_AP022563:c1236361-1236029 [Mycolicibacterium duvalii]
GTGAACCGAGGGGAAATTTGGACCGTAGCGGGGGGCGTCTACGCGGGGAAGCCGCGTCCGGCAGTGATCGTTCAGGATGA
CCTCTTTGATGCCACGCGCTCGGTGACTGTTGCGCCGATGACCAGCGCGCTGTTGGATGCGCCGCTGATGCGCATTCGGA
TAGCCGGCAGAGATGGTCGACTATCCGGACTTGACCACGACAGCGACGTGATGATCGATAAGCTCACCACCGTGAGAAGG
TCGAACGTCCACGCACGGGTCGGCCGGCTGACGGCGGAGCAAGTCGTCGAGGTCGAGCGGGCAATGATGGCTTTTCTCGG
CCTTGCCCGGTAA

Antitoxin


Download         Length: 69 a.a.        Molecular weight: 7859.67 Da        Isoelectric Point: 4.4929

>AT36149 WP_098002641.1 NZ_AP022563:c1236564-1236358 [Mycolicibacterium duvalii]
MAVRERVGEYRRRMRERGLRPLQVWVPDVRTETFAAEAHRQASLVAGADESGDDQEFVEAISTPWDEE

Download         Length: 207 bp

>AT36149 NZ_AP022563:c1236564-1236358 [Mycolicibacterium duvalii]
ATGGCAGTGAGGGAAAGGGTTGGCGAGTACCGACGACGGATGCGGGAGCGTGGCCTCCGGCCTCTGCAGGTCTGGGTGCC
CGATGTGCGAACCGAGACTTTTGCGGCCGAGGCTCATCGCCAGGCTTCGTTGGTGGCAGGAGCGGACGAGAGCGGCGACG
ACCAAGAGTTCGTCGAGGCGATCTCGACACCGTGGGATGAGGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References