Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-Phd
Location 85902..86446 Replicon chromosome
Accession NZ_AP022563
Organism Mycolicibacterium duvalii strain JCM 6396

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag G6N31_RS00465 Protein ID WP_098005206.1
Coordinates 86183..86446 (+) Length 88 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag G6N31_RS00460 Protein ID WP_098005205.1
Coordinates 85902..86186 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6N31_RS00445 82452..82775 - 324 WP_098005203.1 helix-turn-helix domain-containing protein -
G6N31_RS00450 83094..84455 - 1362 WP_098005231.1 recombinase family protein -
G6N31_RS00455 84577..85311 + 735 WP_098005204.1 hypothetical protein -
G6N31_RS00460 85902..86186 + 285 WP_098005205.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
G6N31_RS00465 86183..86446 + 264 WP_098005206.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
G6N31_RS00470 86540..87337 + 798 WP_098005207.1 SDR family NAD(P)-dependent oxidoreductase -
G6N31_RS00475 87413..87799 + 387 WP_098005208.1 hypothetical protein -
G6N31_RS00480 87853..88221 + 369 WP_098005209.1 DUF1801 domain-containing protein -
G6N31_RS00485 88234..88728 - 495 WP_098005210.1 nitroreductase family deazaflavin-dependent oxidoreductase -
G6N31_RS00490 88738..89007 - 270 WP_133117716.1 hypothetical protein -
G6N31_RS00495 89071..89712 - 642 WP_098005212.1 hypothetical protein -
G6N31_RS00500 89820..90512 - 693 WP_098005213.1 guanylate cyclase -
G6N31_RS26950 90540..90716 + 177 WP_098005214.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(32-86)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 88 a.a.        Molecular weight: 10178.90 Da        Isoelectric Point: 11.5448

>T36148 WP_098005206.1 NZ_AP022563:86183-86446 [Mycolicibacterium duvalii]
VTYRVELTSAAKRALTELLPKAVAVACWEFIRGPLAERPHRVGKPLRGHLEGRYSARRGEFRVLYRVFDDRVVVRVIHIA
HRRDVYR

Download         Length: 264 bp

>T36148 NZ_AP022563:86183-86446 [Mycolicibacterium duvalii]
GTGACTTATCGCGTCGAGCTCACCAGCGCCGCGAAGAGGGCACTGACCGAGCTGCTTCCTAAGGCTGTCGCGGTCGCATG
TTGGGAGTTCATTCGGGGTCCATTGGCGGAACGTCCGCATCGGGTAGGCAAGCCGCTGCGCGGCCATTTGGAAGGCCGGT
ACTCCGCACGACGCGGCGAATTCCGGGTTCTATATCGGGTTTTCGACGACCGGGTAGTCGTCCGCGTCATCCATATCGCC
CACCGTCGTGATGTCTATCGGTGA

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10572.95 Da        Isoelectric Point: 4.4909

>AT36148 WP_098005205.1 NZ_AP022563:85902-86186 [Mycolicibacterium duvalii]
MTTLPLAEVRAQLSKLVDEAVRTHERVEVTRQGRRAAVILSADDYDSIMETLAILSDQELMRDVRAAEAQAERGEIFTLD
EVTEEMRAAGRLSR

Download         Length: 285 bp

>AT36148 NZ_AP022563:85902-86186 [Mycolicibacterium duvalii]
ATGACGACACTGCCCTTGGCCGAAGTTCGGGCCCAATTGTCGAAGCTCGTCGATGAGGCCGTCCGCACCCATGAGCGCGT
CGAGGTCACGCGGCAGGGTCGTCGTGCAGCGGTGATCCTCAGCGCCGACGACTACGACTCGATCATGGAGACGCTGGCCA
TCCTCAGCGACCAGGAGTTGATGCGCGACGTCCGGGCAGCGGAGGCGCAGGCCGAGCGTGGCGAGATCTTCACGCTCGAC
GAGGTGACCGAGGAGATGCGCGCCGCCGGGCGACTGTCTCGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References