Detailed information of TA system TA036146

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-RHH
• Location: 2117765..2118309
• Replicon: chromosome
• Accession: NZ_AP022562
• Organism: Mycobacterium novum strain JCM 6391

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: G6N19_RS09845
• Protein ID: WP_193466228.1
• Coordinates: 2117765..2118061 (-)
• Length: 99 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: F5YUZ3
• Locus tag: G6N19_RS09850
• Protein ID: WP_013831127.1
• Coordinates: 2118058..2118309 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G6N19_RS09825	2113636..2114775	-	1140	WP_193466225.1	epoxide hydrolase	-
G6N19_RS09830	2114768..2115364	-	597	WP_193466226.1	TetR/AcrR family transcriptional regulator	-
G6N19_RS09835	2115442..2117205	+	1764	WP_193466227.1	amidohydrolase family protein	-
G6N19_RS09840	2117241..2117744	+	504	WP_193466359.1	SRPBCC family protein	-
G6N19_RS09845	2117765..2118061	-	297	WP_193466228.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
G6N19_RS09850	2118058..2118309	-	252	WP_013831127.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
G6N19_RS09855	2118356..2119582	-	1227	WP_193466360.1	cytochrome P450	-
G6N19_RS09860	2119634..2120578	+	945	WP_193466229.1	SDR family NAD(P)-dependent oxidoreductase	-
G6N19_RS09865	2120538..2121167	-	630	WP_193466230.1	TetR/AcrR family transcriptional regulator	-
G6N19_RS09870	2121263..2121733	-	471	WP_193466361.1	SRPBCC family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-93)

Antitoxin

• Antitoxin ParD (1-80)

Sequences

Toxin

Protein

• Length: 99 a.a.
• Molecular weight: 11446.00 Da
• Isoelectric Point: 7.2752

>T36146 WP_193466228.1 NZ_AP022562:c2118061-2117765 [Mycobacterium novum]
VTVRYLLSPAARADLEQIWDYTADRWGVDQAEEYLRELQYAIERLAAKPRIGRTCDEIRPGYRKLSAGSHTLFYRLTADA
VVDVVRVLHQRMDTERHL

Nucleotide

• Length: 297 bp

>T36146 NZ_AP022562:c2118061-2117765 [Mycobacterium novum]
GTGACTGTTCGATACCTGCTCTCACCTGCCGCGCGAGCAGATCTGGAACAGATCTGGGATTACACCGCGGACCGCTGGGG
CGTCGACCAGGCCGAAGAGTACCTGCGCGAGCTCCAGTACGCGATCGAACGTCTTGCCGCGAAGCCACGGATCGGCCGAA
CCTGTGACGAGATCCGACCCGGCTATCGCAAACTATCGGCCGGATCCCACACGCTGTTCTATCGACTGACTGCCGACGCC
GTCGTCGACGTAGTTCGGGTCTTGCACCAACGGATGGACACCGAGCGGCATCTCTGA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9551.60 Da
• Isoelectric Point: 5.1634

>AT36146 WP_013831127.1 NZ_AP022562:c2118309-2118058 [Mycobacterium novum]
MGKNTSFVLDDHYQAFIDQEIAAGRYRSVSEVIRSALRLLEDREAQLRALRTALEDGERSGESTPFDFDAFLDRKRTDAS
RIR

Nucleotide

• Length: 252 bp

>AT36146 NZ_AP022562:c2118309-2118058 [Mycobacterium novum]
ATGGGCAAGAACACGTCCTTCGTGCTCGACGATCATTACCAGGCCTTCATCGACCAGGAGATCGCAGCCGGACGCTACCG
ATCGGTCAGCGAGGTTATCCGCTCGGCATTGCGGCTGCTGGAGGATCGCGAAGCACAACTGCGGGCCCTGCGCACCGCCC
TCGAGGACGGTGAACGTAGCGGCGAGTCGACGCCGTTTGACTTCGATGCCTTCCTCGACCGCAAACGGACGGATGCGTCG
CGTATCCGGTGA

Structures

Antitoxin

• AlphaFold DB: A0A7I9YEV9