Detailed information of TA system TA036142

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 1348859..1349538
• Replicon: chromosome
• Accession: NZ_AP022562
• Organism: Mycobacterium novum strain JCM 6391

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: A0A7I9Y442
• Locus tag: G6N19_RS06145
• Protein ID: WP_019736075.1
• Coordinates: 1348859..1349290 (-)
• Length: 144 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: -
• Locus tag: G6N19_RS06150
• Protein ID: WP_019736076.1
• Coordinates: 1349287..1349538 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
G6N19_RS06120	1345461..1345667	-	207	WP_193465986.1	hypothetical protein	-
G6N19_RS06125	1345893..1346309	-	417	WP_083039923.1	hypothetical protein	-
G6N19_RS06130	1346622..1346984	+	363	WP_013827530.1	DoxX family protein	-
G6N19_RS06135	1347000..1347776	-	777	WP_193465987.1	thioesterase family protein	-
G6N19_RS06140	1347818..1348657	+	840	WP_193465988.1	methyltransferase domain-containing protein	-
G6N19_RS06145	1348859..1349290	-	432	WP_019736075.1	type II toxin-antitoxin system VapC family toxin	Toxin
G6N19_RS06150	1349287..1349538	-	252	WP_019736076.1	ribbon-helix-helix domain-containing protein	Antitoxin
G6N19_RS06155	1349678..1350454	+	777	WP_193466316.1	thioesterase family protein	-
G6N19_RS06160	1350507..1351787	+	1281	WP_193465989.1	DUF4226 domain-containing protein	-
G6N19_RS06165	1351807..1352160	+	354	WP_065288081.1	hypothetical protein	-
G6N19_RS06170	1352157..1352459	+	303	WP_019736167.1	hypothetical protein	-
G6N19_RS06175	1352590..1353225	+	636	WP_065288082.1	DUF4226 domain-containing protein	-
G6N19_RS06180	1353261..1353554	+	294	WP_193465990.1	hypothetical protein	-
G6N19_RS06185	1353568..1353915	+	348	WP_193465991.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-123)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 144 a.a.
• Molecular weight: 15054.11 Da
• Isoelectric Point: 4.8989

>T36142 WP_019736075.1 NZ_AP022562:c1349290-1348859 [Mycobacterium novum]
MIVLDTTVLVYAKGADHRFREPCRDLIAAVAADRIEATTTPEVIQEFVHIRARRRGRNDAATLGRSYAELLAPLLTVAGD
HLERGLTMFETTPSVGAFDSVLAAVAKSAGAVLVSADGAFSDLPDITHVVPDTAGVAGLLGDN

Nucleotide

• Length: 432 bp

>T36142 NZ_AP022562:c1349290-1348859 [Mycobacterium novum]
ATGATCGTGCTGGACACCACGGTGCTCGTCTATGCCAAGGGCGCCGACCACCGGTTCAGGGAGCCGTGCCGTGACTTGAT
CGCGGCGGTTGCCGCCGACCGCATTGAAGCGACCACTACCCCCGAAGTGATCCAGGAGTTCGTCCATATTCGTGCCCGCC
GACGTGGCCGCAACGATGCCGCAACGCTGGGGCGCAGCTACGCCGAGCTGCTCGCGCCCCTGCTGACTGTCGCTGGCGAC
CACCTCGAGCGAGGATTGACGATGTTCGAGACGACCCCGAGTGTTGGTGCCTTTGATTCCGTGCTGGCTGCGGTCGCCAA
ATCTGCCGGGGCGGTACTGGTCTCGGCGGACGGTGCGTTCAGCGACCTCCCCGACATCACCCATGTAGTGCCCGACACCG
CGGGCGTCGCCGGCCTGCTCGGCGACAATTGA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9286.57 Da
• Isoelectric Point: 9.0090

>AT36142 WP_019736076.1 NZ_AP022562:c1349538-1349287 [Mycobacterium novum]
MSPLEHRLQILLDDERHRRLTAAARERGVSVASVVREAIDRGLAGPVDRRKSAGQRLLDAPDMPVPDPAELKQELDELRG
RRG

Nucleotide

• Length: 252 bp

>AT36142 NZ_AP022562:c1349538-1349287 [Mycobacterium novum]
ATGTCTCCTTTGGAGCATCGACTGCAGATCCTGCTCGACGACGAACGCCATCGCCGACTGACCGCGGCGGCACGGGAACG
TGGCGTCTCAGTGGCCAGCGTGGTGCGCGAAGCCATCGATCGCGGCCTCGCGGGCCCCGTCGACCGCCGCAAATCCGCCG
GTCAGCGCCTTCTCGACGCTCCTGACATGCCGGTTCCCGACCCCGCCGAACTCAAGCAGGAATTGGACGAACTGCGCGGA
CGCCGCGGATGA

Structures

Toxin

• AlphaFold DB: A0A7I9Y442