Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 968668..969510 Replicon chromosome
Accession NZ_AP022562
Organism Mycobacterium novum strain JCM 6391

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag G6N19_RS04465 Protein ID WP_193465847.1
Coordinates 968668..969201 (-) Length 178 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID -
Locus tag G6N19_RS04470 Protein ID WP_193466298.1
Coordinates 969208..969510 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6N19_RS04435 963709..964041 + 333 WP_193465845.1 DUF732 domain-containing protein -
G6N19_RS04440 964038..965084 - 1047 WP_013827893.1 EcsC family protein -
G6N19_RS04445 965163..965768 + 606 WP_013827892.1 TetR/AcrR family transcriptional regulator -
G6N19_RS04450 965765..966589 + 825 WP_013827891.1 hypothetical protein -
G6N19_RS04455 966612..967826 - 1215 WP_041317259.1 cytochrome P450 -
G6N19_RS04460 968021..968596 + 576 WP_193465846.1 TetR/AcrR family transcriptional regulator -
G6N19_RS04465 968668..969201 - 534 WP_193465847.1 GNAT family N-acetyltransferase Toxin
G6N19_RS04470 969208..969510 - 303 WP_193466298.1 DUF1778 domain-containing protein Antitoxin
G6N19_RS04480 969927..971048 - 1122 WP_193465848.1 hypothetical protein -
G6N19_RS04485 971194..971856 - 663 WP_193465849.1 GNAT family N-acetyltransferase -
G6N19_RS04490 971867..973138 - 1272 WP_193465850.1 molybdopterin molybdotransferase MoeA -
G6N19_RS04495 973186..974097 - 912 WP_041317256.1 UTP--glucose-1-phosphate uridylyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(35-147)

Antitoxin

Vibrio phage ICP1, Orf50

(16-92)


Sequences

Toxin        


Download         Length: 178 a.a.        Molecular weight: 19109.91 Da        Isoelectric Point: 9.4475

>T36141 WP_193465847.1 NZ_AP022562:c969201-968668 [Mycobacterium novum]
VTSGAKSSARKPKPPQKLTREHDRTGFSSGAAELDEWLAKYSWQNQRANNATTYVSTVEGRVVGYYAITVAGIARSEAPE
AIAKRAPATVPCFLLARLAVDVEWQGCGLGWGLLRDVLRRVLQLSESVAAPALLVHARDDAARAFYLHHVEFLPSPIDPL
HLLLPTKAIAAAMGGNV

Download         Length: 534 bp

>T36141 NZ_AP022562:c969201-968668 [Mycobacterium novum]
GTGACTAGCGGCGCTAAGAGCAGCGCGCGCAAGCCGAAGCCGCCACAGAAACTGACCAGGGAGCACGACCGAACCGGATT
CTCCTCCGGCGCCGCCGAACTGGACGAATGGTTAGCGAAGTACAGCTGGCAGAATCAGCGAGCCAACAACGCGACCACCT
ATGTGAGCACCGTCGAGGGCCGGGTGGTCGGCTACTACGCCATCACCGTTGCTGGTATCGCACGTAGCGAAGCCCCTGAA
GCGATCGCCAAACGCGCACCCGCGACGGTGCCCTGTTTCCTGCTGGCCAGACTGGCGGTAGATGTCGAATGGCAGGGCTG
CGGTCTCGGGTGGGGTCTATTGCGCGATGTGCTCCGCCGAGTCCTGCAGCTCTCGGAGTCTGTGGCAGCTCCTGCGCTGC
TCGTTCACGCTCGCGACGACGCTGCTCGGGCGTTCTACCTGCACCATGTCGAATTCCTGCCTTCACCGATCGACCCGTTG
CATTTGCTCTTGCCGACCAAGGCCATCGCGGCAGCGATGGGCGGGAATGTCTAG

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11522.94 Da        Isoelectric Point: 4.8839

>AT36141 WP_193466298.1 NZ_AP022562:c969510-969208 [Mycobacterium novum]
MSNGHAPSTKATRDQRLNFRASAQQQLLIRQAAEAADRTVTDFILGSVLESAERILADRKWFVANDEQWERFQELLDAPL
QPMPKLRQLLQRESPFAEEE

Download         Length: 303 bp

>AT36141 NZ_AP022562:c969510-969208 [Mycobacterium novum]
ATGAGCAACGGCCACGCTCCGTCCACCAAAGCCACGCGTGATCAGCGACTGAACTTCAGGGCCAGCGCTCAACAGCAGCT
GCTGATCCGGCAGGCTGCCGAAGCCGCCGACCGTACTGTCACCGACTTCATCCTGGGCAGCGTTCTGGAAAGTGCCGAGC
GGATACTCGCCGACCGCAAGTGGTTTGTGGCTAACGATGAGCAATGGGAGCGGTTCCAGGAACTCCTGGATGCGCCGCTG
CAGCCCATGCCGAAGCTGCGTCAGCTACTGCAACGCGAAAGCCCATTCGCAGAAGAGGAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References