Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 75880..76569 Replicon chromosome
Accession NZ_AP022562
Organism Mycobacterium novum strain JCM 6391

Toxin (Protein)


Gene name vapC Uniprot ID F5Z1X3
Locus tag G6N19_RS00330 Protein ID WP_013828735.1
Coordinates 75880..76311 (-) Length 144 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID F5Z1X2
Locus tag G6N19_RS00335 Protein ID WP_013828734.1
Coordinates 76318..76569 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6N19_RS00315 71316..74054 - 2739 WP_193465551.1 DNA polymerase I -
G6N19_RS00320 74151..74594 + 444 WP_083038228.1 Zn-ribbon domain-containing OB-fold protein -
G6N19_RS00325 74591..75793 + 1203 WP_083038134.1 lipid-transfer protein -
G6N19_RS00330 75880..76311 - 432 WP_013828735.1 type II toxin-antitoxin system VapC family toxin Toxin
G6N19_RS00335 76318..76569 - 252 WP_013828734.1 hypothetical protein Antitoxin
G6N19_RS00340 76612..76848 + 237 WP_013828733.1 DUF167 domain-containing protein -
G6N19_RS00345 76857..77603 - 747 WP_013828732.1 proteasome subunit alpha -
G6N19_RS00350 77600..78484 - 885 WP_193465552.1 proteasome subunit beta -
G6N19_RS00355 78481..78675 - 195 WP_013828730.1 ubiquitin-like protein Pup -
G6N19_RS00360 78863..79117 + 255 WP_013828729.1 hypothetical protein -
G6N19_RS00365 79114..79503 + 390 WP_013828728.1 PIN domain-containing protein -
G6N19_RS00370 79558..81066 - 1509 WP_013828727.1 proteasome accessory factor PafA2 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-132)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 144 a.a.        Molecular weight: 15414.46 Da        Isoelectric Point: 5.8935

>T36139 WP_013828735.1 NZ_AP022562:c76311-75880 [Mycobacterium novum]
MKIVDANVLLYAVNTAAEHHDASLRWLDRALSGADTVGFAWVPLLAFVRLSTKEGLFPHPLRPEDAVDRVAEWTAASSAV
VVNPTPRHADILTGLLARVGAGGNLVNDAHLAALAIEHRGGIVSYDADFGRFGIRWDRPDDLA

Download         Length: 432 bp

>T36139 NZ_AP022562:c76311-75880 [Mycobacterium novum]
ATGAAGATCGTCGACGCCAATGTGTTGCTCTATGCGGTGAACACTGCCGCAGAGCACCATGACGCCTCGCTGCGCTGGCT
CGACCGTGCGCTGTCCGGAGCGGACACGGTTGGCTTCGCCTGGGTTCCGCTACTGGCGTTCGTCCGGCTCTCCACCAAGG
AGGGTTTGTTTCCCCATCCGCTGCGGCCGGAGGACGCGGTGGACCGGGTGGCCGAGTGGACCGCGGCATCTAGTGCGGTA
GTCGTCAATCCCACGCCTCGACATGCCGACATCCTGACCGGGCTGCTCGCCCGCGTCGGCGCCGGGGGAAACCTGGTGAA
CGACGCGCACCTGGCGGCGCTCGCCATCGAGCACCGCGGCGGAATCGTTTCCTACGACGCGGATTTCGGCCGATTCGGGA
TCCGTTGGGATCGGCCCGACGACCTGGCGTAG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9422.59 Da        Isoelectric Point: 6.3412

>AT36139 WP_013828734.1 NZ_AP022562:c76569-76318 [Mycobacterium novum]
MRTTVTLDDDVEQLIRRRMAERQLSFKQALNEAIRDGSAGRATPQFQTRTADLGVPSVNLDRALQLAADLEDEELIRRQR
RGA

Download         Length: 252 bp

>AT36139 NZ_AP022562:c76569-76318 [Mycobacterium novum]
ATGCGCACCACCGTGACATTGGATGATGACGTCGAGCAGTTGATTCGTCGCCGGATGGCAGAACGTCAGCTGTCGTTCAA
GCAGGCGCTCAACGAGGCGATCCGCGACGGATCGGCCGGCCGCGCAACACCGCAATTCCAGACCCGGACCGCTGATCTCG
GGGTCCCGTCGGTCAATCTGGACAGGGCACTGCAGCTTGCTGCGGATCTGGAGGACGAAGAGCTGATCCGCCGGCAACGC
CGCGGTGCCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7I9Y887

Antitoxin

Source ID Structure
AlphaFold DB A0A7I7JGW9

References