Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/Polyketide_cyc2(toxin)
Location 899907..900563 Replicon chromosome
Accession NZ_AP022561
Organism Mycolicibacterium aichiense strain JCM 6376

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID -
Locus tag G6N32_RS04395 Protein ID WP_115317189.1
Coordinates 900117..900563 (+) Length 149 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID -
Locus tag G6N32_RS04390 Protein ID WP_115317191.1
Coordinates 899907..900113 (+) Length 69 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6N32_RS04380 895918..897504 + 1587 WP_115317194.1 serine hydrolase -
G6N32_RS04385 897501..899903 + 2403 WP_115317192.1 HAD-IC family P-type ATPase -
G6N32_RS04390 899907..900113 + 207 WP_115317191.1 antitoxin Antitoxin
G6N32_RS04395 900117..900563 + 447 WP_115317189.1 SRPBCC family protein Toxin
G6N32_RS04400 900584..900964 - 381 WP_115317187.1 hypothetical protein -
G6N32_RS04405 901105..901332 + 228 WP_036341208.1 hypothetical protein -
G6N32_RS04410 901334..901993 - 660 WP_115317185.1 response regulator transcription factor -
G6N32_RS04415 902110..902973 + 864 WP_147291999.1 amidohydrolase family protein -
G6N32_RS04420 902970..903842 - 873 WP_115317181.1 hypothetical protein -
G6N32_RS04425 903826..905544 - 1719 WP_115317179.1 NAD-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Polyketide cyclase/dehydrase

(1-144)

Antitoxin

Antitoxin Rv0909/MT0933

(9-55)


Sequences

Toxin        


Download         Length: 149 a.a.        Molecular weight: 16053.71 Da        Isoelectric Point: 9.9407

>T36137 WP_115317189.1 NZ_AP022561:900117-900563 [Mycolicibacterium aichiense]
MAKLSVSVDVPLPPEQAWQHASDLSRYKDWLTIHRVWRSKLPETLEKGTVVESIVEVKGMPNRVKWEIVHFKAPEAMTLN
GAGVGGVKVKLIGKVRPNDKDANTSVVTMDVHLGGAALFGPIGMVVAGALKGDIKESLDRFVAVFSPS

Download         Length: 447 bp

>T36137 NZ_AP022561:900117-900563 [Mycolicibacterium aichiense]
ATGGCGAAACTCTCTGTATCCGTAGATGTTCCATTACCGCCCGAGCAGGCGTGGCAGCACGCCTCGGACCTGTCGCGCTA
CAAGGACTGGCTGACCATCCACCGGGTGTGGCGCTCCAAGCTGCCCGAGACCCTCGAAAAGGGCACCGTCGTGGAGTCCA
TCGTCGAGGTCAAGGGCATGCCCAACCGGGTGAAGTGGGAGATCGTCCACTTCAAGGCGCCGGAAGCCATGACACTCAAC
GGCGCCGGTGTGGGTGGGGTCAAGGTCAAGCTGATCGGCAAGGTGCGGCCGAATGATAAGGACGCCAACACCTCGGTGGT
GACCATGGATGTCCACCTGGGCGGCGCGGCACTGTTCGGCCCGATCGGCATGGTCGTGGCCGGCGCGCTGAAGGGCGACA
TCAAGGAGTCGCTGGACCGCTTCGTCGCGGTCTTTAGTCCGTCCTAG

Antitoxin


Download         Length: 69 a.a.        Molecular weight: 7303.99 Da        Isoelectric Point: 4.5105

>AT36137 WP_115317191.1 NZ_AP022561:899907-900113 [Mycolicibacterium aichiense]
MGFLDKALGKTKEVLGENADKVGQAIDKAGDIIDQKTQGKYSSTVDKVQDAANNYVESNRTDKGDEPS

Download         Length: 207 bp

>AT36137 NZ_AP022561:899907-900113 [Mycolicibacterium aichiense]
ATGGGATTCCTCGACAAAGCCCTCGGCAAGACCAAGGAAGTCTTGGGTGAGAATGCCGACAAAGTGGGCCAGGCCATCGA
CAAGGCCGGCGACATCATCGACCAAAAGACGCAGGGCAAGTACTCCAGCACCGTAGACAAGGTGCAGGATGCCGCCAACA
ACTACGTCGAGTCCAACCGCACCGACAAAGGCGACGAACCAAGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References