Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/Polyketide_cyc2(toxin)
Location 1516779..1517416 Replicon chromosome
Accession NZ_AP022560
Organism Mycolicibacterium moriokaense strain JCM 6375

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID -
Locus tag G6N43_RS07445 Protein ID WP_083149125.1
Coordinates 1516970..1517416 (+) Length 149 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID -
Locus tag G6N43_RS07440 Protein ID WP_083149126.1
Coordinates 1516779..1516961 (+) Length 61 a.a.

Genomic Context

G6N43_RS07430G6N43_RS07435G6N43_RS07440G6N43_RS07445G6N43_RS07450G6N43_RS07455G6N43_RS07460G6N43_RS07465G6N43_RS07470
Location: 1512808..1514382 (1575 bp)
Type: Others
Protein ID: WP_083149128.1
Location: 1514379..1516769 (2391 bp)
Type: Others
Protein ID: WP_083149127.1
Location: 1516779..1516961 (183 bp)
Type: Antitoxin
Protein ID: WP_083149126.1
Location: 1516970..1517416 (447 bp)
Type: Toxin
Protein ID: WP_083149125.1
Location: 1517502..1518062 (561 bp)
Type: Others
Protein ID: WP_083149124.1
Location: 1518062..1519288 (1227 bp)
Type: Others
Protein ID: WP_083149123.1
Location: 1519285..1519698 (414 bp)
Type: Others
Protein ID: WP_083149122.1
Location: 1519695..1520753 (1059 bp)
Type: Others
Protein ID: WP_083149121.1
Location: 1520746..1521795 (1050 bp)
Type: Others
Protein ID: WP_083149120.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
G6N43_RS074301512808..1514382+1575WP_083149128.1serine hydrolase-
G6N43_RS074351514379..1516769+2391WP_083149127.1cation-translocating P-type ATPase-
G6N43_RS074401516779..1516961+183WP_083149126.1antitoxinAntitoxin
G6N43_RS074451516970..1517416+447WP_083149125.1SRPBCC family proteinToxin
G6N43_RS074501517502..1518062-561WP_083149124.1isomerase-
G6N43_RS074551518062..1519288-1227WP_083149123.1cytochrome P450-
G6N43_RS074601519285..1519698-414WP_083149122.1hypothetical protein-
G6N43_RS074651519695..1520753-1059WP_083149121.1dihydrodipicolinate reductase-
G6N43_RS074701520746..1521795-1050WP_083149120.1dihydrodipicolinate reductase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Polyketide cyclase/dehydrase

(1-145)

Antitoxin

Antitoxin Rv0909/MT0933

(4-52)


Sequences

Toxin        


Download         Length: 149 a.a.        Molecular weight: 16101.85 Da        Isoelectric Point: 10.2304

>T36136 WP_083149125.1 NZ_AP022560:1516970-1517416 [Mycolicibacterium moriokaense]
MAKLSVSVDVPLPPEKAWESASDLPRYKEWLTVHKVWRSKLPETLEKGTAIESIVEVKGMPVRVKWTIVHFKPPETITLD
GKGEGGVKVKLIGKVRPSKKVDAGSSVTFDVHLGGPALFGPIGMVVAGALKSDFRESLDRFQAVFAPA

Download         Length: 447 bp

>T36136 NZ_AP022560:1516970-1517416 [Mycolicibacterium moriokaense]
ATGGCAAAACTTTCCGTCTCCGTCGACGTTCCTCTTCCGCCGGAGAAGGCGTGGGAATCCGCGTCTGATCTGCCCCGCTA
CAAGGAGTGGCTGACCGTCCACAAGGTGTGGCGGAGCAAGCTGCCAGAAACCCTTGAGAAGGGCACGGCCATCGAGTCGA
TCGTCGAAGTCAAGGGCATGCCCGTGCGGGTCAAGTGGACCATCGTCCACTTCAAGCCGCCCGAGACAATCACCCTCGAT
GGCAAGGGCGAGGGCGGCGTCAAGGTCAAGCTCATCGGCAAGGTGCGGCCCTCCAAGAAGGTCGACGCGGGGTCGAGCGT
CACCTTCGACGTGCACCTCGGCGGCCCTGCGTTGTTCGGACCCATCGGGATGGTGGTCGCCGGCGCGCTGAAGAGCGATT
TCCGGGAGTCGTTGGACCGCTTCCAGGCCGTGTTCGCCCCAGCCTGA

Antitoxin


Download         Length: 61 a.a.        Molecular weight: 6546.46 Da        Isoelectric Point: 8.5550

>AT36136 WP_083149126.1 NZ_AP022560:1516779-1516961 [Mycolicibacterium moriokaense]
MAILDKVKNLLAKNADKVDTAIDKAGDIVDEKTQGKYAQHIDKVQEAAKKAVDKNNPQTP

Download         Length: 183 bp

>AT36136 NZ_AP022560:1516779-1516961 [Mycolicibacterium moriokaense]
ATGGCAATCCTCGACAAGGTGAAGAATCTGCTGGCCAAGAATGCCGACAAGGTGGACACCGCGATCGACAAGGCCGGTGA
CATCGTCGACGAGAAGACGCAGGGCAAATACGCCCAGCACATCGACAAGGTGCAGGAGGCCGCCAAGAAGGCGGTCGACA
AGAACAACCCGCAGACCCCCTAG

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
No matching records found

References