Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) unclassified/Polyketide_cyc2(toxin)
Location 1516779..1517416 Replicon chromosome
Accession NZ_AP022560
Organism Mycolicibacterium moriokaense strain JCM 6375

Toxin (Protein)


Gene name novel[antitoxin] Uniprot ID -
Locus tag G6N43_RS07445 Protein ID WP_083149125.1
Coordinates 1516970..1517416 (+) Length 149 a.a.

Antitoxin (Protein)


Gene name novel[toxin] Uniprot ID -
Locus tag G6N43_RS07440 Protein ID WP_083149126.1
Coordinates 1516779..1516961 (+) Length 61 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
G6N43_RS07430 1512808..1514382 + 1575 WP_083149128.1 serine hydrolase -
G6N43_RS07435 1514379..1516769 + 2391 WP_083149127.1 cation-translocating P-type ATPase -
G6N43_RS07440 1516779..1516961 + 183 WP_083149126.1 antitoxin Antitoxin
G6N43_RS07445 1516970..1517416 + 447 WP_083149125.1 SRPBCC family protein Toxin
G6N43_RS07450 1517502..1518062 - 561 WP_083149124.1 isomerase -
G6N43_RS07455 1518062..1519288 - 1227 WP_083149123.1 cytochrome P450 -
G6N43_RS07460 1519285..1519698 - 414 WP_083149122.1 hypothetical protein -
G6N43_RS07465 1519695..1520753 - 1059 WP_083149121.1 dihydrodipicolinate reductase -
G6N43_RS07470 1520746..1521795 - 1050 WP_083149120.1 dihydrodipicolinate reductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Polyketide cyclase/dehydrase

(1-145)

Antitoxin

Antitoxin Rv0909/MT0933

(4-52)


Sequences

Toxin        


Download         Length: 149 a.a.        Molecular weight: 16101.85 Da        Isoelectric Point: 10.2304

>T36136 WP_083149125.1 NZ_AP022560:1516970-1517416 [Mycolicibacterium moriokaense]
MAKLSVSVDVPLPPEKAWESASDLPRYKEWLTVHKVWRSKLPETLEKGTAIESIVEVKGMPVRVKWTIVHFKPPETITLD
GKGEGGVKVKLIGKVRPSKKVDAGSSVTFDVHLGGPALFGPIGMVVAGALKSDFRESLDRFQAVFAPA

Download         Length: 447 bp

>T36136 NZ_AP022560:1516970-1517416 [Mycolicibacterium moriokaense]
ATGGCAAAACTTTCCGTCTCCGTCGACGTTCCTCTTCCGCCGGAGAAGGCGTGGGAATCCGCGTCTGATCTGCCCCGCTA
CAAGGAGTGGCTGACCGTCCACAAGGTGTGGCGGAGCAAGCTGCCAGAAACCCTTGAGAAGGGCACGGCCATCGAGTCGA
TCGTCGAAGTCAAGGGCATGCCCGTGCGGGTCAAGTGGACCATCGTCCACTTCAAGCCGCCCGAGACAATCACCCTCGAT
GGCAAGGGCGAGGGCGGCGTCAAGGTCAAGCTCATCGGCAAGGTGCGGCCCTCCAAGAAGGTCGACGCGGGGTCGAGCGT
CACCTTCGACGTGCACCTCGGCGGCCCTGCGTTGTTCGGACCCATCGGGATGGTGGTCGCCGGCGCGCTGAAGAGCGATT
TCCGGGAGTCGTTGGACCGCTTCCAGGCCGTGTTCGCCCCAGCCTGA

Antitoxin


Download         Length: 61 a.a.        Molecular weight: 6546.46 Da        Isoelectric Point: 8.5550

>AT36136 WP_083149126.1 NZ_AP022560:1516779-1516961 [Mycolicibacterium moriokaense]
MAILDKVKNLLAKNADKVDTAIDKAGDIVDEKTQGKYAQHIDKVQEAAKKAVDKNNPQTP

Download         Length: 183 bp

>AT36136 NZ_AP022560:1516779-1516961 [Mycolicibacterium moriokaense]
ATGGCAATCCTCGACAAGGTGAAGAATCTGCTGGCCAAGAATGCCGACAAGGTGGACACCGCGATCGACAAGGCCGGTGA
CATCGTCGACGAGAAGACGCAGGGCAAATACGCCCAGCACATCGACAAGGTGCAGGAGGCCGCCAAGAAGGCGGTCGACA
AGAACAACCCGCAGACCCCCTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References