Detailed information of TA system TA036119

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX-GNAT
• Location: 4242716..4243536
• Replicon: chromosome
• Accession: NZ_AP022549
• Organism: Escherichia coli strain THO-015

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: B6I030
• Locus tag: JLF69_RS20625
• Protein ID: WP_001054379.1
• Coordinates: 4242716..4242973 (+)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: -
• Locus tag: JLF69_RS20630
• Protein ID: WP_000123957.1
• Coordinates: 4242985..4243536 (+)
• Length: 184 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JLF69_RS20605	4238263..4239243	+	981	WP_000991462.1	9-O-acetyl-N-acetylneuraminic acid deacetylase	-
JLF69_RS20610	4239826..4240932	-	1107	Protein_4042	DNA helicase	-
JLF69_RS20615	4240995..4242142	+	1148	WP_085949154.1	IS3-like element ISEc52 family transposase	-
JLF69_RS20620	4242175..4242339	+	165	Protein_4044	GNAT family N-acetyltransferase	-
JLF69_RS20625	4242716..4242973	+	258	WP_001054379.1	YjhX family toxin	Toxin
JLF69_RS20630	4242985..4243536	+	552	WP_000123957.1	N-acetyltransferase	Antitoxin
JLF69_RS20635	4243588..4244334	+	747	WP_000354249.1	class I SAM-dependent methyltransferase	-
JLF69_RS20640	4244462..4244722	+	261	WP_000077645.1	hypothetical protein	-
JLF69_RS20645	4244760..4244876	+	117	Protein_4049	VOC family protein	-
JLF69_RS20650	4245121..4246242	+	1122	WP_000010833.1	M42 family metallopeptidase	-
JLF69_RS20655	4246239..4246517	+	279	WP_000722973.1	PTS sugar transporter subunit IIB	-
JLF69_RS20660	4246529..4247842	+	1314	WP_000460845.1	galactitol-specific PTS transporter subunit IIC	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	fimE	4231337..4251757	20420

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

• GNAT domain (19-121)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9568.07 Da
• Isoelectric Point: 11.1381

>T36119 WP_001054379.1 NZ_AP022549:4242716-4242973 [Escherichia coli]
MNLSRQEQRTLHVLAKGGRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTGLNNVRA
QLDNR

Nucleotide

• Length: 258 bp

>T36119 NZ_AP022549:4242716-4242973 [Escherichia coli]
ATGAATTTATCCCGTCAGGAACAACGTACGTTACACGTTCTCGCTAAAGGTGGACGTATTGCGCACGTCCGCGATTCTTC
AGGCCGCGTCACTTCCGTTGAATGCTACAGCCGCGAAGGGCTGTTGCTGACCGACTGCACGCTCGCCGTCTTCAAAAAAC
TCAAAACCAAAAAACTTATCAAGTCCGTCAATGGTCAGCCCTATCGAATCAACACTACCGGGCTGAATAACGTTCGCGCT
CAGCTCGATAATCGCTAA

Antitoxin

Protein

• Length: 184 a.a.
• Molecular weight: 20358.34 Da
• Isoelectric Point: 6.4182

>AT36119 WP_000123957.1 NZ_AP022549:4242985-4243536 [Escherichia coli]
MTAHHFTFQITDESDASDIREVETRAFGFSKEADLTASLLEDESARPALSLLARHEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQALTA
QPMNVTGHIQCAQALMKPEHWRE

Nucleotide

• Length: 552 bp

>AT36119 NZ_AP022549:4242985-4243536 [Escherichia coli]
ATGACAGCACACCACTTCACTTTTCAAATCACAGATGAAAGTGATGCCAGTGATATCCGGGAAGTCGAAACCCGCGCATT
TGGCTTCAGCAAAGAAGCCGATTTAACGGCCTCTTTACTTGAGGATGAAAGCGCGCGCCCTGCGTTATCGCTGCTGGCCC
GACATGAAGGCAAAGCCGTCGGGCATATTTTATTTACCCGGGCAACCTTCAAAGGGGAAATGGATTCACCGCTGATGCAT
ATCCTCGCTCCCCTGGCAGTCATACCGGAATACCAGGGGATGGGCGTGGGAGGACGGTTGATACGCACTGGCATCGAGCA
CCTGAGGTTGATGGGCTGCCAGACGGTTTTTGTTCTCGGCCACGCCACCTATTACCCCCGACATGGGTTCGAACCCTGTG
CCGGAGACAAAGGCTATCCGGCACCTTATCCCATCCCGGAGGAGCACAAAGCCTGCTGGATGATGCAAGCACTCACCGCT
CAGCCCATGAACGTGACCGGCCACATCCAGTGCGCGCAGGCCCTGATGAAACCGGAGCACTGGCGTGAATAA

Structures

Toxin

• AlphaFold DB: B6I030