Detailed information of TA system TA036091

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): yjhX-yjhQ/YjhX-ArgA
• Location: 4765282..4766101
• Replicon: chromosome
• Accession: NZ_AP022547
• Organism: Klebsiella michiganensis strain THO-011

Toxin (Protein)

• Gene name: yjhX
• Uniprot ID: J5WT09
• Locus tag: JLG71_RS22385
• Protein ID: WP_004110819.1
• Coordinates: 4765844..4766101 (-)
• Length: 86 a.a.

Antitoxin (Protein)

• Gene name: yjhQ
• Uniprot ID: -
• Locus tag: JLG71_RS22380
• Protein ID: WP_200913827.1
• Coordinates: 4765282..4765833 (-)
• Length: 184 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JLG71_RS22365	4761504..4762412	-	909	WP_064405202.1	transcriptional regulator GcvA	-
JLG71_RS22370	4762532..4763419	+	888	WP_200913826.1	DMT family transporter	-
JLG71_RS22375	4763636..4765264	-	1629	WP_200914326.1	SAM-dependent methyltransferase	-
JLG71_RS22380	4765282..4765833	-	552	WP_200913827.1	N-acetyltransferase	Antitoxin
JLG71_RS22385	4765844..4766101	-	258	WP_004110819.1	YjhX family toxin	Toxin
JLG71_RS22390	4766777..4767961	+	1185	WP_200913828.1	mannonate dehydratase	-
JLG71_RS22395	4768035..4769510	+	1476	WP_014228053.1	fructuronate reductase	-
JLG71_RS22400	4769649..4770425	+	777	WP_185219607.1	Uxu operon transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Putative toxin of bacterial toxin-antitoxin pair (1-85)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9552.07 Da
• Isoelectric Point: 11.1381

>T36091 WP_004110819.1 NZ_AP022547:c4766101-4765844 [Klebsiella michiganensis]
MNLSRQEQRTLHVLAKGGRIAHIRDASGRVTSVECYSREGLLLSDCTLAVFKKLKTKKLIKSVNGQPYRINTTGLNNVRA
QLDNR

Nucleotide

• Length: 258 bp

>T36091 NZ_AP022547:c4766101-4765844 [Klebsiella michiganensis]
ATGAATCTATCCCGTCAGGAACAACGTACCTTACACGTTCTCGCTAAAGGTGGCCGGATCGCGCACATCCGCGATGCATC
AGGCCGCGTCACCTCTGTTGAATGCTACAGCCGCGAAGGGCTCCTGCTCAGCGACTGCACGCTCGCCGTTTTCAAAAAAC
TCAAAACCAAAAAGCTGATTAAGTCCGTCAACGGACAGCCCTACCGCATCAATACCACCGGGCTGAATAACGTCCGCGCA
CAGCTGGACAATCGCTAA

Antitoxin

Protein

• Length: 184 a.a.
• Molecular weight: 20094.93 Da
• Isoelectric Point: 6.3270

>AT36091 WP_200913827.1 NZ_AP022547:c4765833-4765282 [Klebsiella michiganensis]
MTNHSFTFHVASEGDTDDILDVETRAFGYSKEARLVADLLNDESACPTLSLLARHNGEAVGHILFTRATFKGEPDSPMMH
ILAPLAVVPEYQGVGVGGELIRHGIEQLKAMGSQMVFVLGHAAYYPRHGFEPCAGDKGYPAPYPIPEAHKACWMLQPISS
QPLGRTGQIQCARALMKPEHWRE

Nucleotide

• Length: 552 bp

>AT36091 NZ_AP022547:c4765833-4765282 [Klebsiella michiganensis]
ATGACAAACCACAGCTTCACTTTTCATGTCGCCTCTGAAGGCGATACCGATGACATTCTCGACGTCGAAACCCGGGCTTT
CGGCTACAGCAAAGAGGCCAGGCTGGTGGCCGATTTGCTCAACGATGAGAGTGCCTGCCCGACGCTATCGCTGCTGGCCA
GGCATAACGGAGAGGCGGTTGGGCATATTTTATTCACCCGGGCGACGTTCAAAGGGGAGCCGGACTCGCCGATGATGCAC
ATCCTTGCTCCCCTGGCGGTGGTGCCGGAATACCAGGGCGTGGGCGTTGGCGGAGAGCTTATCCGGCACGGCATTGAGCA
GTTGAAAGCAATGGGAAGCCAGATGGTATTTGTTCTGGGCCACGCCGCTTACTACCCCAGGCACGGGTTTGAGCCATGCG
CGGGAGATAAAGGCTATCCGGCGCCTTATCCGATTCCCGAGGCGCATAAAGCCTGCTGGATGCTGCAGCCGATTTCGTCT
CAGCCGCTGGGACGAACGGGCCAGATACAGTGCGCCCGGGCGTTAATGAAACCCGAGCACTGGCGCGAGTAA

Structures

Toxin

• AlphaFold DB: A0A0H3H6Y2