36076

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 56833..57380 Replicon chromosome
Accession NZ_AP022547
Organism Klebsiella michiganensis strain THO-011

Toxin (Protein)


Gene name ccdB Uniprot ID A0A0H3H5T3
Locus tag JLG71_RS00285 Protein ID WP_014227299.1
Coordinates 56833..57141 (-) Length 103 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID A0A0H3H0P7
Locus tag JLG71_RS00290 Protein ID WP_014227298.1
Coordinates 57144..57380 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JLG71_RS00260 52737..53048 - 312 WP_014227304.1 PTS sugar transporter subunit IIB -
JLG71_RS00265 53343..54284 + 942 WP_025107585.1 LacI family transcriptional regulator -
JLG71_RS00270 54308..54601 - 294 WP_064357598.1 hypothetical protein -
JLG71_RS00275 54811..55776 + 966 WP_064357600.1 Rpn family recombination-promoting nuclease/putative transposase -
JLG71_RS00280 55780..56682 - 903 WP_014227300.1 EamA family transporter -
JLG71_RS00285 56833..57141 - 309 WP_014227299.1 CcdB family protein Toxin
JLG71_RS00290 57144..57380 - 237 WP_014227298.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
JLG71_RS00295 57486..58919 - 1434 WP_048262922.1 PTS N-acetylmuramic acid transporter subunit IIBC -
JLG71_RS00300 58944..59846 - 903 WP_009654080.1 N-acetylmuramic acid 6-phosphate etherase -
JLG71_RS00305 60007..61173 - 1167 WP_025107588.1 multidrug effflux MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-101)

Antitoxin

Post-segregation antitoxin CcdA

(8-78)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11725.57 Da        Isoelectric Point: 7.2729

>T36076 WP_014227299.1 NZ_AP022547:c57141-56833 [Klebsiella michiganensis]
MQYYVYKNTGRIAAYPYLLDVQSDIIGKRNTRVVIPLFPLKNYKGPRADRLTPLVTVEGEEYVVMTHELASIPHRVLGEE
VCNLNHQREVVKASMDFLFDGI

Download         Length: 309 bp

>T36076 NZ_AP022547:c57141-56833 [Klebsiella michiganensis]
ATGCAGTATTACGTTTATAAGAATACAGGTCGAATTGCTGCGTATCCTTACCTCCTTGATGTACAGAGTGACATTATCGG
CAAGCGCAATACTCGGGTCGTAATTCCACTGTTTCCACTGAAAAACTATAAAGGTCCACGCGCCGATCGTTTAACACCGC
TTGTCACCGTAGAAGGGGAAGAATACGTCGTGATGACTCACGAACTCGCCAGCATCCCACATCGTGTTCTGGGTGAAGAA
GTTTGTAATCTGAATCACCAGCGCGAAGTCGTTAAAGCTTCAATGGATTTTCTTTTCGACGGGATCTAA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8783.92 Da        Isoelectric Point: 5.7928

>AT36076 WP_014227298.1 NZ_AP022547:c57380-57144 [Klebsiella michiganensis]
MPAAKRNKQNVSVTLDPGLVKQAREVGINLSLTLTNALKSEIHSLEIARWQKENAQAIDYLNNLTEENGLLSDEYRTF

Download         Length: 237 bp

>AT36076 NZ_AP022547:c57380-57144 [Klebsiella michiganensis]
ATGCCAGCCGCAAAACGCAATAAGCAGAACGTCAGCGTGACACTGGACCCAGGCCTGGTTAAACAGGCTCGTGAGGTCGG
CATCAATCTGTCTCTAACGTTGACTAACGCTCTAAAAAGCGAAATCCACAGCCTCGAAATAGCCCGCTGGCAAAAAGAAA
ATGCCCAGGCAATCGACTACCTCAATAATTTAACTGAGGAAAATGGACTTCTCTCTGATGAATACAGGACGTTCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3H5T3

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3H0P7

References