Detailed information of TA system TA036055

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): yeeUV (cbtA-cbeA)/CbtA-CbeA
• Location: 2893352..2894192
• Replicon: chromosome
• Accession: NZ_AP022540
• Organism: Escherichia coli strain THO-010

Toxin (Protein)

• Gene name: yeeV
• Uniprot ID: B1LJY4
• Locus tag: JLH08_RS13675
• Protein ID: WP_000854686.1
• Coordinates: 2893352..2893735 (-)
• Length: 128 a.a.

Antitoxin (Protein)

• Gene name: yeeU
• Uniprot ID: A0A1M0YJ34
• Locus tag: JLH08_RS13680
• Protein ID: WP_001360163.1
• Coordinates: 2893812..2894192 (-)
• Length: 127 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
JLH08_RS13635	2888354..2888845	-	492	WP_001383029.1	DUF1097 domain-containing protein	-
JLH08_RS13640	2888947..2889501	-	555	WP_021556694.1	molecular chaperone YcdY	-
JLH08_RS13645	2889525..2890262	-	738	WP_200930344.1	phosphatase	-
JLH08_RS13650	2890317..2891255	-	939	WP_040234658.1	glyoxylate/hydroxypyruvate reductase GhrA	-
JLH08_RS13660	2891726..2892568	-	843	WP_001274547.1	DUF4942 domain-containing protein	-
JLH08_RS13665	2892653..2892850	-	198	WP_000839253.1	DUF957 domain-containing protein	-
JLH08_RS13670	2892867..2893355	-	489	WP_001054233.1	hypothetical protein	-
JLH08_RS13675	2893352..2893735	-	384	WP_000854686.1	TA system toxin CbtA family protein	Toxin
JLH08_RS13680	2893812..2894192	-	381	WP_001360163.1	type IV toxin-antitoxin system YeeU family antitoxin	Antitoxin
JLH08_RS13685	2894203..2894886	-	684	WP_200930345.1	antitoxin of toxin-antitoxin stability system	-
JLH08_RS13690	2894905..2895126	-	222	WP_000692298.1	DUF987 domain-containing protein	-
JLH08_RS13695	2895189..2895665	-	477	WP_001186726.1	RadC family protein	-
JLH08_RS13700	2895681..2896166	-	486	WP_000214307.1	antirestriction protein	-
JLH08_RS13705	2896258..2897076	-	819	WP_001234732.1	DUF945 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• CbtA toxin of type IV toxin-antitoxin system (1-113)

Antitoxin

• Antitoxin CbeA (18-117)

Sequences

Toxin

Protein

• Length: 128 a.a.
• Molecular weight: 14272.28 Da
• Isoelectric Point: 6.8614

>T36055 WP_000854686.1 NZ_AP022540:c2893735-2893352 [Escherichia coli]
MKTLPDTHVRAASRCPSPVEIWQTLLTRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYVLVRTDQPGF
SAGAPSSQLINSIDILRARRATGLMTRDNYRMVNNITLGKHPEEAKQ

Nucleotide

• Length: 384 bp

>T36055 NZ_AP022540:c2893735-2893352 [Escherichia coli]
ATGAAAACATTACCCGACACACACGTACGGGCGGCATCGCGCTGCCCGTCTCCGGTTGAAATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTATGGCCTTACGTTGAATGACACACCGTTCGCTGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGGATTTCACTGTGTGACGCGGTGAACTTTCTCGTTGAAAAATACGTGCTGGTACGAACTGACCAGCCGGGATTC
AGCGCAGGAGCCCCGTCGTCTCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCG
GGACAATTACAGAATGGTAAATAACATTACCCTGGGCAAGCATCCGGAGGAGGCGAAACAATGA

Antitoxin

Protein

• Length: 127 a.a.
• Molecular weight: 13950.74 Da
• Isoelectric Point: 5.0823

>AT36055 WP_001360163.1 NZ_AP022540:c2894192-2893812 [Escherichia coli]
VSDTLPGTTLPDDNKDRPWWGLPCIVTPCFGARLVQEGNRLHYLADRAGIRGRFSNADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCDADTLGSCGYVYLAVYPATETESNPPE

Nucleotide

• Length: 381 bp

>AT36055 NZ_AP022540:c2894192-2893812 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACGCTTCCCGACGACAACAAAGACCGCCCCTGGTGGGGGCTGCCCTGCATCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCAGACCGCGCCGGTATCAGAGGCCGGT
TCAGCAATGCGGATGCATACCATCTGGACCAGGCTTTTCCACTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGGCATCAGCATACCGTCACGCTGTATGCGAAAGGGCTGACCTGCGATGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCTGCGACCGAAACGGAAAGTAACCCTCCGGAATAG

Structures

Antitoxin

• AlphaFold DB: A0A1M0YJ34