36027

Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) relBE/RelE-HTH_XRE
Location 3282099..3282804 Replicon chromosome
Accession NZ_AP022536
Organism Escherichia coli strain THO-008

Toxin (Protein)


Gene name relE Uniprot ID S1F406
Locus tag JLF34_RS15720 Protein ID WP_000539521.1
Coordinates 3282099..3282485 (+) Length 129 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag JLF34_RS15725 Protein ID WP_001280945.1
Coordinates 3282475..3282804 (+) Length 110 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JLF34_RS15700 3278103..3278729 + 627 WP_001314584.1 glutathione S-transferase GstB -
JLF34_RS15705 3278726..3279841 - 1116 WP_000555033.1 aldose sugar dehydrogenase YliI -
JLF34_RS15710 3279952..3280335 - 384 WP_000497137.1 biofilm formation regulator BssR -
JLF34_RS15715 3280548..3281873 + 1326 WP_000049367.1 30S ribosomal protein S12 methylthiotransferase RimO -
JLF34_RS15720 3282099..3282485 + 387 WP_000539521.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
JLF34_RS15725 3282475..3282804 + 330 WP_001280945.1 DNA-binding transcriptional regulator Antitoxin
JLF34_RS15730 3282874..3284202 - 1329 WP_001586846.1 GGDEF domain-containing protein -
JLF34_RS15735 3284210..3286558 - 2349 WP_001305945.1 EAL domain-containing protein -
JLF34_RS15740 3286736..3287647 - 912 WP_001236042.1 glutathione ABC transporter permease GsiD -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(1-124)

Antitoxin

(53-94)


Sequences


Toxin        


Download         Length: 129 a.a.        Molecular weight: 14293.45 Da        Isoelectric Point: 9.9296

>T36027 WP_000539521.1 NZ_AP022536:3282099-3282485 [Escherichia coli]
MGVYKARRFSQSTKKLGIHDKVLMAAAEEVMQGIWEADLGSGVIKKRLPLQQGKSGGARTIIFFKSANHVFFYDGWSKSG
LSSKGTKEIEDDELAAYKKMANAFLAFSNKQIEDLIETGFLIEVKNER

Download         Length: 387 bp

>T36027 NZ_AP022536:3282099-3282485 [Escherichia coli]
ATGGGTGTGTATAAGGCAAGACGATTCAGCCAAAGCACGAAAAAACTTGGTATTCACGATAAAGTTCTCATGGCTGCCGC
TGAAGAAGTGATGCAGGGCATATGGGAGGCTGATTTAGGTAGCGGTGTCATCAAAAAACGTTTACCCCTCCAACAAGGAA
AGAGTGGTGGAGCCAGAACAATTATCTTTTTTAAATCAGCAAATCATGTGTTTTTTTATGATGGTTGGTCCAAGAGTGGT
CTAAGCAGTAAAGGAACCAAAGAAATCGAAGATGATGAACTGGCGGCCTACAAAAAAATGGCAAATGCATTTCTGGCCTT
TAGCAATAAGCAAATAGAGGATTTGATCGAAACTGGCTTTTTGATTGAGGTGAAAAATGAGCGATAA

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 11982.08 Da        Isoelectric Point: 10.0101

>AT36027 WP_001280945.1 NZ_AP022536:3282475-3282804 [Escherichia coli]
MSDKLQMMLEDAKELNALGLMSDSEVDAIAVMVKAREVSARIAKVKSMTGEEIKAIRTRYGMSQSVLAHTMGMSKESVSK
WERNEIKPSGPALRILNTLAIKGPEVFAK

Download         Length: 330 bp

>AT36027 NZ_AP022536:3282475-3282804 [Escherichia coli]
ATGAGCGATAAATTACAAATGATGCTGGAAGATGCAAAGGAACTGAATGCACTGGGCCTGATGTCTGATAGTGAAGTTGA
TGCCATTGCCGTCATGGTCAAAGCTCGTGAAGTCAGCGCCCGTATAGCCAAAGTCAAATCAATGACGGGTGAAGAGATCA
AAGCCATCCGCACCCGATACGGCATGTCACAATCCGTGCTGGCACATACAATGGGAATGTCAAAAGAAAGTGTCTCGAAA
TGGGAACGTAATGAAATAAAACCGAGCGGCCCGGCATTACGTATTTTGAATACATTGGCAATAAAAGGGCCGGAAGTTTT
TGCAAAGTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A829GCT6


Antitoxin

Source ID Structure

References