Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeUV (cbtA-cbeA)/CbtA-CbeA
Location 1959029..1959860 Replicon chromosome
Accession NZ_AP022536
Organism Escherichia coli strain THO-008

Toxin (Protein)


Gene name yeeV Uniprot ID S1P968
Locus tag JLF34_RS09085 Protein ID WP_000854814.1
Coordinates 1959029..1959403 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID B3Y195
Locus tag JLF34_RS09090 Protein ID WP_001285585.1
Coordinates 1959492..1959860 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
JLF34_RS09045 1954425..1955591 + 1167 WP_000830150.1 serine-type D-Ala-D-Ala carboxypeptidase DacD -
JLF34_RS09050 1955710..1956183 + 474 WP_001105389.1 DNA gyrase inhibitor SbmC -
JLF34_RS09055 1956381..1957439 + 1059 WP_001200891.1 FUSC family protein -
JLF34_RS09060 1957611..1957940 + 330 WP_000450409.1 DUF496 family protein -
JLF34_RS09065 1958041..1958223 - 183 WP_032140263.1 ethanolamine utilization protein -
JLF34_RS09070 1958295..1958423 + 129 Protein_1774 transposase domain-containing protein -
JLF34_RS09075 1958712..1958825 - 114 WP_001161660.1 DUF957 domain-containing protein -
JLF34_RS09080 1958838..1959032 - 195 WP_000988600.1 hypothetical protein -
JLF34_RS09085 1959029..1959403 - 375 WP_000854814.1 type IV toxin-antitoxin system toxin CbtA Toxin
JLF34_RS09090 1959492..1959860 - 369 WP_001285585.1 type IV toxin-antitoxin system toxin CbtA Antitoxin
JLF34_RS09095 1959934..1960155 - 222 WP_000692323.1 DUF987 domain-containing protein -
JLF34_RS09100 1960218..1960694 - 477 WP_001186726.1 RadC family protein -
JLF34_RS09105 1960710..1961189 - 480 WP_000860087.1 antirestriction protein -
JLF34_RS09110 1961271..1962089 - 819 WP_021538423.1 DUF945 domain-containing protein -
JLF34_RS09115 1962189..1962422 - 234 WP_001119729.1 DUF905 family protein -
JLF34_RS09120 1962501..1962956 - 456 WP_000581504.1 hypothetical protein -
JLF34_RS09125 1963032..1963874 - 843 Protein_1785 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(18-117)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13898.94 Da        Isoelectric Point: 7.8522

>T36014 WP_000854814.1 NZ_AP022536:c1959403-1959029 [Escherichia coli]
MKTLPVLPGQAASSRPSPVEIWQILLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITLGKYPEAK

Download         Length: 375 bp

>T36014 NZ_AP022536:c1959403-1959029 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTATGGCCTCACACTGAATGACACACCTTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCACGCCGGGCAACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13593.48 Da        Isoelectric Point: 6.3139

>AT36014 WP_001285585.1 NZ_AP022536:c1959860-1959492 [Escherichia coli]
VSDTLPGTTLPDDNHDRPWWGLPCTVTPCFGARLVQEGNRLHYLADRAGIRGLFSDADAYHLDQAFPLLMKQLELMLTSG
ELNPRHQHTVTLYAKGLTCKADTLSSCGYVYLAVYPTPEMKN

Download         Length: 369 bp

>AT36014 NZ_AP022536:c1959860-1959492 [Escherichia coli]
GTGTCAGACACACTCCCCGGGACAACACTTCCCGACGACAATCACGACCGCCCCTGGTGGGGGCTGCCCTGCACCGTGAC
GCCCTGTTTCGGGGCACGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCTGT
TCAGCGATGCAGATGCGTACCACCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGCTCACCAGCGGT
GAACTGAATCCCCGCCATCAGCATACCGTCACGCTGTATGCAAAAGGGCTGACCTGCAAAGCCGATACCCTCAGCAGTTG
TGGTTACGTTTATCTGGCTGTTTATCCGACGCCCGAAATGAAAAATTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FY50

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LW60

References